Vesicular inhibitory amino acid transport

Stable Identifier
R-HSA-428625
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Gamma-Aminobutyric acid (GABA) is the major inhibitory
transmitter of the vertebrate retina. The gene SLC32A1 encodes the vesicular inhibitory amino acid transporter (VIAAT, also called vesicular GABA transporter VGAT) (Jellali A et al, 2002). VIAAT is a proton-coupled amino acid antiporter, uptaking the inhibitory neurotransmitters GABA and glycine into synaptic vesicles in exchange for protons. This process is driven by the H+-ATPase, providing the driving force for uptake of these neurotransmitters. The protein is expressed throughout the terminal ends of horizontal cells of the retina.

Literature References
PubMed ID Title Journal Year
12115694 Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina

Jellali, A, Stussi-Garaud, C, Gasnier, B, Rendon, A, Sahel, JA, Dreyfus, H, Picaud, S

J Comp Neurol 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
gamma-aminobutyric acid:proton symporter activity of SLC32A1 [synaptic vesicle membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed