sphinganine 1-phosphate => phosphoethanolamine + hexadecanal

Stable Identifier
R-HSA-428681
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SGPL1 (sphingosine-1-phosphate lyase 1), associated with the endoplasmic reticulum membrane, catalyzes the cleavage of cytosolic sphinganine (dihydrosphingosine) 1-phosphate to form phosphoethanolamine and hexadecanal (Van Veldhoven et al. 2000; Fyrst and Saba 2008).

Literature References
PubMed ID Title Journal Year
18558101 Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight

Fyrst, H, Saba, JD

Biochim Biophys Acta 2008
11018465 Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1)

Van Veldhoven, PP, Gijsbers, S, Mannaerts, GP, Vermeesch, JR, Brys, V

Biochim Biophys Acta 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sphinganine-1-phosphate aldolase activity of PXLP-SGPL1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created