sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]

Stable Identifier
R-HSA-428701
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SGPP1 and 2 (sphingosine-1-phosphate phosphatase 1 and 2) enzymes associated with the endoplasmic reticulum membrane catalyze the hydrolysis of cytosolic sphingosine 1-phosphate to form sphingosine and orthophosphate (Johnson et al. 2003; Ogawa et al. 2003).

Literature References
PubMed ID Title Journal Year
12815058 Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability

Johnson, KR, Johnson, KY, Becker, KP, Bielawski, J, Mao, C, Obeid, LM

J Biol Chem 2003
12411432 Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2

Ogawa, C, Kihara, A, Gokoh, M, Igarashi, Y

J Biol Chem 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sphingosine-1-phosphate phosphatase activity of SGPP [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created