Reactome | CAP2 [cytosol]

CAP2 [cytosol]

Stable Identifier

R-HSA-428863

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Adenylyl cyclase-associated protein 2, CAP2_HUMAN

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Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Role of ABL in ROBO-SLIT signaling (Homo sapiens)
        
        Recruitment of CAP to ABL (Homo sapiens)
        
        CAP [cytosol] (Homo sapiens)
        
        CAP2 [cytosol] (Homo sapiens)
        
        SLIT2:ROBO1:ABL:CAP [plasma membrane] (Homo sapiens)
        
        CAP [cytosol] (Homo sapiens)
        
        CAP2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P40123 CAP2

Gene Names

CAP2

Chain

initiator methionine:, chain:2-477

Reference Genes

BioGPS Gene:10486 CAP2

COSMIC (genes):CAP2 CAP2

CTD Gene:10486 CAP2

dbSNP Gene:10486 CAP2

ENSEMBL:ENSG00000112186 CAP2

ENSEMBL_homo_sapiens_GENE:ENSG00000112186.13 CAP2

HGNC:20039 CAP2

KEGG Gene (Homo sapiens):10486 CAP2

Monarch:10486 CAP2

NCBI Gene:10486 CAP2

OMIM:618385 CAP2

UCSC:P40123 CAP2

Reference Transcript

RefSeq:NM_006366.2 CAP2

Other Identifiers

10486

11721641_a_at

11721642_x_at

11746559_a_at

11748435_a_at

11748436_x_at

11749280_a_at

11756919_a_at

17005138

212551_PM_at

212551_at

212554_PM_at

212554_at

2896889

2896891

2896893

2896909

2896918

2896919

2896922

2896924

2896936

2896937

2896938

2896940

2896941

2896942

2896946

2896952

2896953

33404_at

33405_at

693_g_at

714_at

8117054

A_14_P104479

A_23_P421664

A_33_P3739260

GE63260

GE79143

GO:0000902

GO:0003779

GO:0005515

GO:0005737

GO:0005886

GO:0007010

GO:0007015

GO:0007163

GO:0007165

GO:0007190

GO:0008092

GO:0008179

GO:0014069

GO:0016020

GO:0019933

GO:0023052

GO:0034330

GO:0042802

GO:0043226

GO:0048856

GO:0099140

HMNXSV003007092

Hs.296341.0.S1_3p_at

Hs.296341.0.S2_3p_at

ILMN_1691237

PH_hs_0028140

TC06000114.hg

Participates

as a member of

CAP [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_006357.1

OpenTargets

ENSG00000112186

GeneCards

P40123

HPA

ENSG00000112186-CAP2

Ensembl

ENSP00000417208, ENSP00000418604, ENSP00000229922, ENST00000465994, ENST00000229922, ENSG00000112186, ENST00000493172

PRO

P40123

Pharos - Targets

P40123

Orphanet

28203

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [plasma membrane] (R-HSA-196016)	0.697	5
UniProt:P13196 ALAS1	2	PXLP-ALAS1 [mitochondrial matrix] (R-HSA-1022086) ALAS1 [mitochondrial matrix] (R-HSA-189438)	0.556	3

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