Reactome: A Curated Pathway Database

Recruitment of CAP to ABL

Stable Identifier
R-HSA-428883
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

ABL (ABL1 or ABL2) associated with the complex of ROBO1, SLIT2, and glypican-1 (GPC1) at the plasma membrane binds CAP (CAP1 or CAP2) and regulates its activity to inhibit net actin assembly. Studies of CAP homologs from yeast, Dictyostelium, mouse, pig, and human suggest that the C-terminal actin binding domain acts to sequester actin monomers to prevent actin polymerization (Wills et al. 2002).

Participants
Participant Of
Inferred From