Role of ABL in ROBO-SLIT signaling

Stable Identifier
R-HSA-428890
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

ABL (ABL1 or ABL2) plays a dual role in the ROBO pathway. As a key enzymatic component in the signaling pathway, ABL supports repellent signaling (by recruiting the necessary actin binding proteins) and also feeds back on the receptor (by down regulating through phosphorylation) to adjust the sensitivity of the pathway.
ABL cooperates with multiple effectors, including the actin binding protein Capulet (Capt) and Orbit/MAST/CLASP, suggesting that ABL simultaneously coordinates the dynamics of two major cytoskeletal systems to achieve growth cone repellent guidance.

Literature References
PubMed ID Title Journal Year
15207236 The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance

Lee, H, Engel, U, Rusch, J, Scherrer, S, Sheard, K, Van Vactor, D

Neuron 2004
15207230 Hot +TIPS: guidance cues signal directly to microtubules

Kalil, K, Dent, EW

Neuron 2004
12441051 A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding

Wills, Z, Emerson, M, Rusch, J, Bikoff, J, Baum, B, Perrimon, N, Van Vactor, D

Neuron 2002
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