Thromboxane signalling through TP receptor

Stable Identifier
R-HSA-428930
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Thromboxane (TXA2) binds to the thromboxane receptor (TP). There are 2 splice variant forms of TP, differing in their cytoplasmic carboxyl terminal tails. TP beta was first identified in endothelial cells. TP alpha was identified in platelets and placenta. The major signalling route for TP is Gq-mediated stimulation of PLC and consequent increase in cellular calcium. TP also couples to G13, leading to stimulation of Rho and Rac.

Literature References
PubMed ID Title Journal Year
18374420 Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology

Nakahata, N

Pharmacol Ther 2008
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database
Authored
Reviewed