Reactome | p-T180,Y182-MAPK14 [cytosol]

p-T180,Y182-MAPK14 [cytosol]

Stable Identifier

R-HSA-428935

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phospho-MAP kinase p38 alpha, MAP kinase p38 alpha (activated), MAPK14, Mitogen-activated protein kinase 14, MK14_HUMAN, pp38 alpha

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        CD163 mediating an anti-inflammatory response (Homo sapiens)
        
        PLK2, MAPK14 phosphorylate ADAM17 (Homo sapiens)
        
        PLK2, MAPK14 [cytosol] (Homo sapiens)
        
        p-T180,Y182-MAPK14 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
  - KSRP (KHSRP) binds and destabilizes mRNA (Homo sapiens)
    - MAP kinase p38 phosphorylates KSRP (Homo sapiens)
      - Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol] (Homo sapiens)
        
        p-p38 MAPK alpha/beta [cytosol] (Homo sapiens)
        
        p-T180,Y182-MAPK14 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16539 MAPK14

Gene Names

MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A

Chain

initiator methionine:, chain:2-360

Reference Genes

BioGPS Gene:1432 MAPK14

COSMIC (genes):MAPK14 MAPK14

CTD Gene:1432 MAPK14

dbSNP Gene:1432 MAPK14

ENSEMBL:ENSG00000112062 MAPK14

ENSEMBL_homo_sapiens_GENE:ENSG00000112062.12 MAPK14

HGNC:6876 MAPK14

KEGG Gene (Homo sapiens):1432 MAPK14

Monarch:1432 MAPK14

NCBI Gene:1432 MAPK14

OMIM:600289 MAPK14

UCSC:Q16539 MAPK14

Reference Transcript

Other Identifiers

11717276_s_at

11742204_a_at

11742487_a_at

11749297_a_at

11753885_a_at

1432

1671_s_at

17007884

1999_s_at

202530_PM_at

202530_at

210449_PM_x_at

210449_x_at

211087_3p_x_at

211087_PM_x_at

211087_x_at

211561_PM_x_at

211561_x_at

232876_PM_at

232876_at

2904878

2904879

2904884

2904885

2904889

2904891

2904892

2904894

2904896

2904907

2904910

2904913

2904914

2904919

2904920

2904921

2904922

2904923

2904924

2904925

2904930

2904932

37733_at

78240_at

8119000

A_14_P111428

A_23_P426292

A_24_P397566

GE492524

GE57735

GO:0000077

GO:0000165

GO:0000166

GO:0000902

GO:0000922

GO:0001502

GO:0001525

GO:0001649

GO:0001890

GO:0002021

GO:0002062

GO:0002376

GO:0002862

GO:0003824

GO:0004672

GO:0004674

GO:0004707

GO:0004708

GO:0005515

GO:0005524

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005856

GO:0005975

GO:0006006

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006468

GO:0006629

GO:0006886

GO:0006913

GO:0006915

GO:0006935

GO:0006954

GO:0006974

GO:0007155

GO:0007165

GO:0007166

GO:0007178

GO:0007519

GO:0010628

GO:0010831

GO:0012501

GO:0016071

GO:0016301

GO:0016310

GO:0016607

GO:0016740

GO:0018105

GO:0019395

GO:0019899

GO:0019903

GO:0023052

GO:0030154

GO:0030168

GO:0030278

GO:0030316

GO:0031098

GO:0031281

GO:0031410

GO:0031663

GO:0032495

GO:0032496

GO:0032735

GO:0032868

GO:0033554

GO:0034330

GO:0034774

GO:0035331

GO:0035556

GO:0035924

GO:0035994

GO:0036211

GO:0038066

GO:0042060

GO:0042307

GO:0042770

GO:0043226

GO:0045648

GO:0045663

GO:0045944

GO:0046323

GO:0046326

GO:0048010

GO:0048273

GO:0048856

GO:0048863

GO:0051146

GO:0051149

GO:0051403

GO:0051525

GO:0055085

GO:0060045

GO:0060348

GO:0070935

GO:0071222

GO:0071223

GO:0071356

GO:0071479

GO:0071493

GO:0090090

GO:0090336

GO:0090398

GO:0090400

GO:0098586

GO:0098978

GO:0099179

GO:0106310

GO:0140096

GO:1900015

GO:1901741

GO:1904813

GO:2000379

HMNXSV003028633

Hs.258010.0.S1_3p_at

ILMN_1737627

ILMN_2388090

L35253_s_at

L35263_at

PH_hs_0004571

PH_hs_0020050

TC06000523.hg

g405742_3p_s_at

g4503068_3p_at

g7109716_3p_a_at

Participates

as a member of

as a candidate of

Phospho-p38 MAPK [cytosol] (Homo sapiens)

as an output of

Other forms of this molecule

MAPK14 [secretory granule lumen]

MAPK14 [extracellular region]

MAPK14 [ficolin-1-rich granule lumen]

MAPK14 [nucleoplasm]

MAPK14 [cytosol]

p-T180,Y182-MAPK14 [nucleoplasm]

Inferred To

phospho-p-T180,Y182-MAPK14 [cytosol] (Bos taurus)

phospho-p-T180,Y182-MAPK14 [cytosol] (Caenorhabditis elegans)

phospho-p-T180,Y182-MAPK14 [cytosol] (Canis familiaris)

phospho-p-T180,Y182-MAPK14 [cytosol] (Danio rerio)

phospho-p-T180,Y182-MAPK14 [cytosol] (Dictyostelium discoideum)

phospho-p-T180,Y182-MAPK14 [cytosol] (Drosophila melanogaster)

phospho-p-T180,Y182-MAPK14 [cytosol] (Rattus norvegicus)

phospho-p-T180,Y182-MAPK14 [cytosol] (Saccharomyces cerevisiae)

phospho-p-T180,Y182-MAPK14 [cytosol] (Schizosaccharomyces pombe)

phospho-p-T180,Y182-MAPK14 [cytosol] (Sus scrofa)

phospho-p-T180,Y182-MAPK14 [cytosol] (Xenopus tropicalis)

Homologues of p-T180,Y182-MAPK14 [cytosol] (Caenorhabditis elegans)

Homologues of p-T180,Y182-MAPK14 [cytosol] (Dictyostelium discoideum)

Homologues of p-T180,Y182-MAPK14 [cytosol] (Drosophila melanogaster)

phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)

phospho-gska-3 [cytosol] (Caenorhabditis elegans)

phospho-MAPK14 [cytosol] (Gallus gallus)

Modified Residues

Name

O-phospho-L-threonine at 180

Coordinate

180

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at 182

Coordinate

182

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001306.1, NP_620582.1, NP_620583.1, NP_620581.1

ZINC - World Drugs

MK14_HUMAN

Guide to Pharmacology - Targets

1499

OpenTargets

ENSG00000112062

ZINC - FDA approved

MK14_HUMAN

ZINC - Substances

MK14_HUMAN

ZINC - Biogenic

MK14_HUMAN

ZINC target

Q16539

PRO

Q16539

PDB

3UVQ, 3LHJ, 2OKR, 4EH2, 3L8S, 3NWW, 2RG5, 3K3J, 3HLL, 3IW8, 3LFC, 4AA0, 3U8W, 3QUD, 6HWV, 3FI4, 6SFO, 3OEF, 3FLY, 4EHV, 3CTQ, 2BAJ, 4KIP, 3NNX, 3KQ7, 4E5B, 3HP2, 5XYX, 5OMH, 3MH1, 3ZSG, 3L8X, 3MW1, 2FSO, 4FA2, 6QDZ, 4A9Y, 6HWU, 5ETF, 1ZYJ, 6ZQS, 2BAK, 1WBN, 3FMM, 1ZZL, 3E93, 2LGC, 3FC1, 3OC1, 3IW5, 1A9U, 3QUE, 3GCS, 6M95, 4DLI, 3HV6, 6ANL, 4EH7, 1W83, 3FKO, 3ROC, 3GFE, 5WJJ, 3FKL, 3RIN, 5MTY, 1M7Q, 1OZ1, 2YIW, 1WFC, 2RG6, 3HEC, 4AAC, 2BAL, 4E6A, 3LFD, 3O8T, 1OUK, 3GC7, 1W7H, 1BMK, 5N66, 3HA8, 3D7Z, 1YQJ, 3S3I, 1WBW, 5OMG, 4EH5, 6SFK, 3MVL, 3GI3, 3FLQ, 4F9Y, 3ZSH, 1OVE, 3HV3, 6HWT, 3ODY, 5ETI, 3OCG, 3HRB, 3KF7, 3DS6, 3LFE, 5N65, 2FSL, 6SFJ, 4E6C, 3IW6, 4AA4, 3BV2, 4GEO, 6QYX, 3FLS, 3FMJ, 4EH8, 3MGY, 5ETA, 2NPQ, 6TCA, 3NEW, 3MH2, 1OUY, 3FKN, 3LFF, 3OBG, 3FMN, 3PG3, 3UVR, 4EH3, 3FLZ, 1BL7, 1DI9, 5ML5, 3NNU, 4R3C, 2Y8O, 4EH6, 3O8U, 5TCO, 2ZB1, 3FSF, 2ZAZ, 4E5A, 2ONL, 1WBT, 5MTX, 2YIX, 4KIQ, 3HV4, 1WBO, 6QE1, 3ZS5, 3GCU, 2YIS, 6SFI, 6RFO, 3HUB, 3HV7, 3HP5, 4E8A, 3LFA, 2QD9, 3D83, 1W84, 5MZ3, 3FL4, 3C5U, 1R39, 4ZTH, 2FST, 5ETC, 3DT1, 4AA5, 3FMK, 5N64, 3MVM, 3ZYA, 4EWQ, 1KV1, 2BAQ, 3FMH, 3UVP, 2GFS, 3FLN, 5XYY, 6M9L, 6ZWP, 3O8P, 3MH3, 3ZSI, 3K3I, 3S4Q, 3HVC, 4EH4, 5O8V, 1R3C, 3IW7, 3OBJ, 3MPA, 3LFB, 4F9W, 3NNV, 3GCP, 3ITZ, 5N63, 3HL7, 5N68, 3IPH, 1IAN, 4DLJ, 1WBV, 1KV2, 1WBS, 4EH9, 5O8U, 2FSM, 1ZZ2, 3ODZ, 8A8M, 3OD6, 3GCV, 3FSK, 3BX5, 3HUC, 3FLW, 3FML, 3BV3, 3GCQ, 1BL6, 5N67, 3NNW, 4KIN, 4L8M, 6OHD, 3E92, 1W82, 3HV5, 3MH0, 3MPT, 2ZB0, 2I0H, 5TBE, 3HEG

ZINC - Investigational

MK14_HUMAN

ZINC - Metabolites

MK14_HUMAN

GeneCards

Q16539

HPA

ENSG00000112062-MAPK14

Ensembl

ENST00000229795, ENST00000229794, ENSG00000112062, ENST00000310795, ENSP00000229795, ENSP00000229794, ENSP00000308669

Pharos - Targets

Q16539

ZINC - Predictions - Purchasable

MK14_HUMAN

HMDB Protein

HMDBP01516

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49137 MAPKAPK2	5	MAPKAPK2 [cytosol] (R-HSA-187743) p-T222,S272-MAPKAPK2 [nucleoplasm] (R-HSA-199936) p-S272,T222,T334-MAPKAPK2 [cytosol] (R-HSA-187760) p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (R-HSA-450268) MAPKAPK2 [nucleoplasm] (R-HSA-450235)	0.93	15
UniProt:Q16644 MAPKAPK3	4	MAPKAPK3 [cytosol] (R-HSA-187764) MAPKAPK3 [nucleoplasm] (R-HSA-450218) p-S,2T-MAPKAPK3 [nucleoplasm] (R-HSA-450359) p-S,2T-MAPKAPK3 [cytosol] (R-HSA-187723)	0.914	15
UniProt:O75676 RPS6KA4	1	RPS6KA4 [cytosol] (R-HSA-772527)	0.829	9
UniProt:P46734 MAP2K3	3	MAP2K3 [cytosol] (R-HSA-168051) p-S218,T222-MAP2K3 [cytosol] (R-HSA-167955) p-S218,T222-MAP2K3 [nucleoplasm] (R-HSA-450229)	0.802	7
UniProt:Q9BUB5 MKNK1	1	p-T250,T255,T385,S437-MKNK1 [cytosol] (R-HSA-947860)	0.798	7
UniProt:Q9HBH9 MKNK2			0.788	5
UniProt:Q99956 DUSP9	1	DUSP9 [cytosol] (R-HSA-5675351)	0.779	6
UniProt:P28562 DUSP1	1	DUSP1 [nucleoplasm] (R-HSA-203796)	0.767	4
UniProt:Q8NEM7 SUPT20H	1	SUPT20H [nucleoplasm] (R-HSA-3662286)	0.756	5
UniProt:O75147 OBSL1	1	OBSL1 [cytosol] (R-HSA-8955929)	0.725	4
UniProt:O43257 ZNHI1			0.72	7
UniProt:Q15750 TAB1	6	TAB1(445-504) [cytosol] (R-HSA-9729691) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1 [endosome membrane] (R-HSA-450238) TAB1 [cytosol] (R-HSA-167923)	0.713	4
UniProt:P27361 MAPK3	6	MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [nucleoplasm] (R-HSA-73724) MAPK3 [cytosol] (R-HSA-59284) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359)	0.691	5
UniProt:Q15256 PTPRR			0.664	4
UniProt:Q9BY84 DUSP16	3	DUSP16 [cytosol] (R-HSA-5675336) DUSP16 [nucleoplasm] (R-HSA-5675337) Ac-55-DUSP16 [cytosol] (R-HSA-9636576)	0.659	3
UniProt:Q9H0W5 CCDC8	1	CCDC8 [cytosol] (R-HSA-8955915)	0.643	3
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.643	4
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.623	4
UniProt:Q16829 DUSP7	2	DUSP7 [cytosol] (R-HSA-5675346) DUSP7 [nucleoplasm] (R-HSA-203791)	0.59	2
UniProt:P52564 MAP2K6	3	MAP2K6 [cytosol] (R-HSA-167998) p-S207,T211-MAP2K6 [cytosol] (R-HSA-206255) p-S207,T211-MAP2K6 [nucleoplasm] (R-HSA-450258)	0.564	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:Q9H869 YYAP1			0.553	2
UniProt:P68104 EEF1A1	7	Me3K79-EEF1A1 [cytosol] (R-HSA-8932212) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [lysosomal membrane] (R-HSA-9626022)	0.547	3
UniProt:Q15759 MAPK11	4	p-T180,Y182-MAPK11 [nucleoplasm] (R-HSA-198741) MAPK11 [nucleoplasm] (R-HSA-203790) MAPK11 [cytosol] (R-HSA-170989) p-T180,Y182-MAPK11 [cytosol] (R-HSA-171009)	0.547	2
UniProt:Q6PJG2 MDEAS			0.547	2
UniProt:Q14814 MEF2D	1	MEF2D [nucleoplasm] (R-HSA-445328)	0.547	2
UniProt:O75582 RPS6KA5	3	RPS6KA5 [cytosol] (R-HSA-772525) RPS6KA5 [nucleoplasm] (R-HSA-198657) p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm] (R-HSA-198683)	0.547	3
UniProt:Q96RR4 CAMKK2	4	CAMKK2 [cytosol] (R-HSA-9619231) p-CAMKK2 [cytosol] (R-HSA-9619358) CAMKK2 [nucleoplasm] (R-HSA-5336483) p-CAMKK2 [nucleoplasm] (R-HSA-9618968)	0.527	2
UniProt:P51784 USP11	1	USP11 [cytosol] (R-HSA-391303)	0.527	2
UniProt:Q14999 CUL7	1	CUL7 [cytosol] (R-HSA-535534)	0.527	2
UniProt:P13639 EEF2	10	EEF2 [ficolin-1-rich granule lumen] (R-HSA-6801513) EEF2 [extracellular region] (R-HSA-6806499) EEF2 [secretory granule lumen] (R-HSA-6801504) EEF2 [cytosol] (R-HSA-156901) aminocarboxypropyl EEF2 [cytosol] (R-HSA-5358478) Me-diphthine EEF2 [cytosol] (R-HSA-5367025) nascent EEF2 [cytosol] (R-HSA-5358472) diphthine EEF2 [cytosol] (R-HSA-5358501) ADP-ribo-EEF2 [cytosol] (R-HSA-5334764) Me3K525-EEF2 [cytosol] (R-HSA-8932237)	0.527	2
UniProt:Q92574 TSC1	2	TSC1 [plasma membrane] (R-HSA-165169) TSC1 [cytosol] (R-HSA-5672338)	0.508	2
UniProt:Q07352 ZFP36L1	3	p-S54,S92,S203-p-ZFP36L1 [cytosol] (R-HSA-450384) ZFP36L1 [cytosol] (R-HSA-450547) p-S92,S203-ZFP36L1 [cytosol] (R-HSA-450618)	0.508	2