P2Y purinoceptor 1 activates MAP kinase p38 alpha

Stable Identifier
R-HSA-428941
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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ADP activates human platelets and induces endothelial cell migration. These effects are partly mediated by the P2Y1 purinocetor, inducing p38 MAP kinase activation via an uncharacterised factor. Possible mechanisms include flotillin-mediated stimulation of SRC family kinases in lipid rafts (Sugawara et al. 2007).
Literature References
PubMed ID Title Journal Year
10759852 The P2Y1 receptor mediates ADP-induced p38 kinase-activating factor generation in human platelets

Smith, JB, Jin, J, Dangelmaier, C, Kunapuli, SP, Daniel, JL

Eur J Biochem 2000
Participants
Participates
Catalyst Activity

GTPase activity of G-protein alpha (q/11): GTP [plasma membrane]

Orthologous Events
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