ALOX5 is phosphorylated by MAPKAP2

Stable Identifier
R-HSA-429016
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Arachidonate 5-lipoxygenase (ALOX5) catalyzes the first step in leukotriene biosynthesis and has a key role in inflammatory processes. ALOX5 is phosphorylated by MAPKAPK2; MAPKAPK2 is stimulated by arachidonic acid.

Literature References
PubMed ID Title Journal Year
10779545 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases

Werz, O, Klemm, J, Samuelsson, B, Rådmark, O

Proc Natl Acad Sci U S A 2000
11844797 Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2)

Werz, O, Szellas, D, Steinhilber, D, Rådmark, O

J Biol Chem 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S272,T222,T334-MAPKAPK2 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed