Reactome: A Curated Pathway Database

ALOX5 is phosphorylated by MAPKAP2

Stable Identifier
R-HSA-429016
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Arachidonate 5-lipoxygenase (ALOX5) catalyzes the first step in leukotriene biosynthesis and has a key role in inflammatory processes. ALOX5 is phosphorylated by MAPKAPK2; MAPKAPK2 is stimulated by arachidonic acid.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of p-T222,S272,T334-MAPKAPK2 [cytosol] p-T222,S272,T334-MAPKAPK2 [cytosol] protein serine/threonine kinase activity (0004674)
Orthologous Events