Reactome | SLC2A6,8,10,12 transport Glc from extracellular region to cytosol

SLC2A6,8,10,12 transport Glc from extracellular region to cytosol

Stable Identifier

R-HSA-429094

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Glucose transport by class III GLUTs

ReviewStatus

5/5

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SLC2A6,8,10,12 transport Glc from extracellular region to cytosol

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Class III facilitative transporters consist of five members; GLUT6, 8, 10, 12 and HMIT (a H+/myo-inositol transporter). They possess a characteristic glycosylation site on loop 9 (found in loop 1 of classes I and II transporters).

Four class III facilitative transporters can transport glucose. SLC2A6 encodes GLUT6, expressed mainly in brain, spleen and leucocytes (Doege H et al, 2000a). In literature, this protein is incorrectly described as GLUT9. SLC2A8 encodes GLUT8 and is expressed in brain, testis and adipose tissue (Doege H et al, 2000b). SLC2A10 (located in the Type 2 diabetes-linked region of human chromosome 20q12-13.1) encodes GLUT10, a transporter with high affinity for glucose (McVie-Wylie AJ et al, 2001) . GLUT10 is highly expressed in liver and pancreas but is present in most tissues in lower levels. Defects in SLC2A10 are the cause of arterial tortuosity syndrome (ATS), an autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at a young age (Coucke PJ et al, 2006). SLC2A12 encodes GLUT12, which is highly expressed in skeletal muscle, heart and prostate, with lower levels in brain, placenta and kidney. It was originally cloned from the human breast cancer cell line MCF-7 (Rogers S et al, 2002).

Literature References

PubMed ID	Title	Journal	Year
16550171	Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome Callewaert, B, Coucke, PJ, Willems, PJ, Gardella, R, Wessels, MW, Mancini, GM, Barlati, S, Facchetti, F, De Backer, J, Loeys, B, Fox, JE, De Paepe, A, Dietz, HC, Forsyth, R, Colombi, M, Willaert, A, Kambouris, M, Zoppi, N	Nat Genet	2006
11247674	Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility Chen, Y-T, McVie-Wylie, AJ, Lamson, DR	Genomics	2001
11832379	Identification of a novel glucose transporter-like protein-GLUT-12 James, DE, Carty, MD, Docherty, SE, Best, JD, Henderson, MA, Macheda, ML, Rogers, S, Gibbs, EM, Soeller, WC	Am J Physiol Endocrinol Metab	2002
10821868	GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity Doege, H, Bahrenberg, G, Joost, HG, Brauers, A, Schürmann, A	J Biol Chem	2000
10970791	Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes Doege, H, Bocianski, A, Joost, HG, Schürmann, A	Biochem J	2000