Reactome: A Curated Pathway Database

ABCC4 accumulation of dense granule contents

Stable Identifier
R-HSA-429157
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

ABCC4 (Multidrug resistance protein 4 /MOAT-B) is a member of the MRP/ABCC subfamily of ATP-binding cassette transporters, capable of pumping a wide variety of endogenous and xenobiotic anionic compounds out of the cell. ABCC4 also transports molecules involved in cellular signalling, including cyclic nucleotides, eicosanoids, urate and conjugated steroids. ABCC4 has a dual localisation in polarised cells that suggests a key function in cellular protection and extracellular signalling pathways. It is also highly expressed on platelet dense granule membranes where it is believed to contribute to the accumulation of dense granule content.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism of ABCC4 [platelet dense granule membrane] ABCC4 [platelet dense granule membrane] ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism (0015662)
Orthologous Events