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Thrombin binding to GP1b:IX:V
Stable Identifier
R-HSA-429529
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Thrombin binding to GP1b:IX:V (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Thrombin binds to the GP1b-IX-V receptor during platelet aggregation. This leads to increased PAR activation, possibly due to favourable orientation of thrombin towards the PAR extracellular domain.
Literature References
PubMed ID
Title
Journal
Year
12855811
Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation
Dumas, JJ
,
Mosyak, L
,
Somers, WS
,
Kumar, R
,
Seehra, J
Science
2003
Participants
Input
activated thrombin (factor IIa) [extracellular region]
(Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane]
(Homo sapiens)
Output
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane]
(Homo sapiens)
Participates
as an event of
Platelet Aggregation (Plug Formation) (Homo sapiens)
Orthologous Events
Thrombin binding to GP1b:IX:V (Bos taurus)
Thrombin binding to GP1b:IX:V (Gallus gallus)
Thrombin binding to GP1b:IX:V (Mus musculus)
Thrombin binding to GP1b:IX:V (Rattus norvegicus)
Thrombin binding to GP1b:IX:V (Sus scrofa)
Thrombin binding to GP1b:IX:V (Xenopus tropicalis)
Authored
Akkerman, JW (2009-06-03)
Reviewed
Heemskerk, JW (2010-09-01)
Created
Jupe, S (2009-07-16)
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