PRKD1,2,3 phosphorylates COL4A3BP-2

Stable Identifier
R-HSA-429698
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
CERT + ATP => monophospho-CERT + ADP
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Cytosolic PRKD1, 2 and 3 (protein kinase D1, D2 and D3) catalyze the phosphorylation of serine residue 132 of isoform 2 of ceramide transfer protein (COL4A3BP-2, CERT). Protein kinase D (PRKD) is as a crucial regulator of secretory transport at the trans-Golgi network (TGN). Phosphorylation of COL4A3BP-2 reduces its ceramide transfer activity. PRKDs may therefore act as regulators of lipid homeostasis (Fugmann et al. 2007).

Literature References
PubMed ID Title Journal Year
17591919 Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein

Fugmann, T, Hausser, A, Schoffler, P, Schmid, S, Pfizenmaier, K, Olayioye, MA

J Cell Biol 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein kinase C activity of PRKD1,2,3 [cytosol]
Physical Entity
Activity
Orthologous Events
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Created