monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP

Stable Identifier
R-HSA-429714
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic CSNK1G2 (casein kinase 1, gamma 2) catalyzes the phosphorylation of multiple serine and threonine residues of “CERT” (ceramide transfer protein) already phosphorylated on serine-132 (Tomishige et al. 2009). This reaction has the effect of inhibiting ceramide transport from the endoplasmic reticulum to the Golgi apparatus as multiphospho-CERT is unable to bind ceramides or associate with the Golgi membrane.

Literature References
PubMed ID Title Journal Year
19005213 Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin

Tomishige, N, Kumagai, K, Kusuda, J, Nishijima, M, Hanada, K

Mol Biol Cell 2009
Participants
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Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of CSNK1G2 [cytosol]
Physical Entity
Activity
Orthologous Events
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Created