Reactome | OSBP [cytosol]

OSBP [cytosol]

Stable Identifier

R-HSA-429725

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

oxysterol binding protein

Locations in the PathwayBrowser for interactor UniProt:Q6UX41 BTNL8

Expand all

External Reference Information

External Reference

UniProt:P22059 OSBP

Gene Names

OSBP, OSBP1

Chain

initiator methionine:, chain:2-807

Reference Genes

BioGPS Gene:5007 OSBP

COSMIC (genes):OSBP OSBP

CTD Gene:5007 OSBP

dbSNP Gene:5007 OSBP

ENSEMBL:ENSG00000110048 OSBP

ENSEMBL_homo_sapiens_GENE:ENSG00000110048.12 OSBP

HGNC:8503 OSBP

KEGG Gene (Homo sapiens):5007 OSBP

Monarch:5007 OSBP

NCBI Gene:5007 OSBP

OMIM:167040 OSBP

UCSC:P22059 OSBP

Reference Transcript

RefSeq:NM_002556.2 OSBP

Other Identifiers

11728750_a_at

11728751_a_at

11728752_a_at

11755384_s_at

11757856_s_at

16738713

201799_PM_s_at

201799_s_at

201800_PM_s_at

201800_s_at

3374699

3374700

3374701

3374702

3374703

3374704

3374705

3374711

3374713

3374716

3374718

3374719

3374721

3374722

3374723

3374728

3374729

3374730

3374731

3374732

41313_at

5007

50389_at

7948379

91570_at

A_23_P24709

A_23_P336449

GE58122

GO:0000139

GO:0005215

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005802

GO:0005829

GO:0005886

GO:0006629

GO:0006686

GO:0006699

GO:0006869

GO:0008142

GO:0008289

GO:0015248

GO:0015914

GO:0015918

GO:0016020

GO:0019904

GO:0023052

GO:0030054

GO:0032367

GO:0032934

GO:0035627

GO:0035774

GO:0036211

GO:0042531

GO:0043226

GO:0043231

GO:0048471

GO:0061024

GO:0070273

GO:0097038

GO:0120009

GO:0120015

GO:1904411

HMNXSV003046219

Hs.24734.0.S2_3p_a_at

ILMN_1706376

M86917_at

PH_hs_0002177

TC11001827.hg

g10441379_3p_a_at

This entity regulates

Positively

CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Homo sapiens)

Inferred To

Osbp [cytosol] (Drosophila melanogaster)

Osbp [cytosol] (Rattus norvegicus)

obr-1 [cytosol] (Caenorhabditis elegans)

Homologues of OSBP [cytosol] (Saccharomyces cerevisiae)

OSBP [cytosol] (Bos taurus)

OSBP [cytosol] (Canis familiaris)

OSBP [cytosol] (Gallus gallus)

OSBP [cytosol] (Mus musculus)

OSBP [cytosol] (Plasmodium falciparum)

OSBP [cytosol] (Saccharomyces cerevisiae)

OSBP [cytosol] (Schizosaccharomyces pombe)

OSBP [cytosol] (Sus scrofa)

OSH2 [cytosol] (Saccharomyces cerevisiae)

osbF [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_002547.1

OpenTargets

ENSG00000110048

GeneCards

P22059

HPA

ENSG00000110048-OSBP

Ensembl

ENSG00000110048, ENST00000263847, ENSP00000263847

PRO

P22059

Pharos - Targets

P22059

HMDB Protein

HMDBP02829

PDB

2RR3, 7V62

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [cytosol] (R-HSA-9609920)	0.848	9
UniProt:O75344 FKBP6	2	FKBP6 [nucleoplasm] (R-HSA-912512) FKBP6 [cytosol] (R-HSA-5601923)	0.708	5
UniProt:O95292 VAPB	2	VAPB [endoplasmic reticulum membrane] (R-HSA-429718) VAPB [Golgi membrane] (R-HSA-9715115)	0.643	6
UniProt:P33151 CDH5	2	p-S665-VE-cadherin [plasma membrane] (R-HSA-5357435) VE-cadherin [plasma membrane] (R-HSA-418992)	0.527	2
UniProt:Q9NRJ7 PCDBG			0.527	2
UniProt:Q86UE6 LRRTM1	1	LRRTM1 [plasma membrane] (R-HSA-6797964)	0.527	2
UniProt:Q7KYR7 BTN2A1	1	BTN2A1 [plasma membrane] (R-HSA-8851994)	0.527	3
UniProt:Q9HB20 PLEKHA3	1	PLEKHA3 [Golgi membrane] (R-HSA-8870513)	0.527	3
UniProt:Q8WWF5 ZNRF4			0.527	2
UniProt:Q96FV0 LRC46			0.527	2
UniProt:Q6UX41 BTNL8	1	BTNL8 [plasma membrane] (R-HSA-8852007)	0.527	2
UniProt:P05120 SERPINB2	2	SERPINB2 [plasma membrane] (R-HSA-159004) SERPINB2 [extracellular region] (R-HSA-158997)	0.527	3
UniProt:Q8ZNG2 SSEL			0.524	4
UniProt:A0A0H3NDL6 A0A0H3NDL6			0.524	3
UniProt:Q92685 ALG3	5	ALG3 [endoplasmic reticulum membrane] (R-HSA-449287) ALG3 W71R [endoplasmic reticulum membrane] (R-HSA-4720466) ALG3 G118D [endoplasmic reticulum membrane] (R-HSA-4720468) ALG3 M157K [endoplasmic reticulum membrane] (R-HSA-4720484) ALG3 R171Q [endoplasmic reticulum membrane] (R-HSA-4720470)	0.508	2
UniProt:A0A0F6B1Q8 A0A0F6B1Q8			0.462	2
UniProt:A0A0F6B423 A0A0F6B423			0.462	2

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