Reactome | multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B

multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B

Stable Identifier

R-HSA-429732

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

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multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B

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Multiphospho-CERT retains its affinity for VAPA or VAPB (VAMP-associated proteins A or B) and PPM1L (protein phosphatase 1-like) in the endoplasmic reticulum membrane, and can associate with them to form a membrane-associated complex (Saito et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18165232	Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes Saito, S, Matsui, H, Kawano, M, Kumagai, K, Tomishige, N, Hanada, K, Echigo, S, Tamura, S, Kobayashi, T	J Biol Chem	2008