phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]

Stable Identifier
R-HSA-429798
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SGMS1 (sphingomyelin synthase 1) associated with the membrane of the Golgi apparatus catalyzes the reversible reaction of phosphatidylcholine and ceramide to form sphingomyelin and diacylglycerol. Phosphatidylcholine was identified as the source of the phosphocholine moiety donated to ceramide in this reaction, in studies of the mouse enzyme in the 1970s (Diringer et al. 1972; Ullman and Radin 1974). SGMS1 is widely expressed in the body and studies of cultured cells indicate that this reaction provides the major source of cellular sphingomyelin (Yamaoka et al. 2004; Huitema et al. 2004; Tafesse et al. 2007).

Literature References
PubMed ID Title Journal Year
4339164 Evidence for a new biosynthetic pathway of sphingomyelin in SV 40 transformed mouse cells

Diringer, H, Marggraf, WD, Koch, MA, Anderer, FA

Biochem Biophys Res Commun 1972
4817756 The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver

Ullman, MD, Radin, NS

J Biol Chem 1974
17449912 Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells

Tafesse, FG, Huitema, K, Hermansson, M, van der Poel, S, van den Dikkenberg, J, Uphoff, A, Somerharju, P, Holthuis, JC

J Biol Chem 2007
14976195 Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells

Yamaoka, S, Miyaji, M, Kitano, T, Umehara, H, Okazaki, T

J Biol Chem 2004
14685263 Identification of a family of animal sphingomyelin synthases

Huitema, K, van den Dikkenberg, J, Brouwers, JF, Holthuis, JC

EMBO J 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sphingomyelin synthase activity of SGMS1 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created