Reactome | TGOLN2 [cytoplasmic vesicle membrane]

TGOLN2 [cytoplasmic vesicle membrane]

Stable Identifier

R-HSA-429818

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytoplasmic vesicle membrane

Synonyms

Trans-Golgi network integral membrane protein 2, TGON2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O43493 TGOLN2

Gene Names

TGOLN2, TGN46, TGN51

Chain

signal peptide:1-21, chain:22-437

Reference Genes

BioGPS Gene:10618 TGOLN2

COSMIC (genes):TGOLN2 TGOLN2

CTD Gene:10618 TGOLN2

dbSNP Gene:10618 TGOLN2

ENSEMBL:ENSG00000152291 TGOLN2

HGNC:15450 TGOLN2

KEGG Gene (Homo sapiens):10618 TGOLN2

Monarch:10618 TGOLN2

NCBI Gene:10618 TGOLN2

OMIM:603062 TGOLN2

UCSC:O43493 TGOLN2

Reference Transcript

Other Identifiers

0002260162

10618

11716901_s_at

11716902_a_at

11716903_a_at

11716904_s_at

11755687_x_at

1566473_3p_a_at

1566473_a_at

16899619

203833_s_at

203834_s_at

212040_3p_at

212040_at

212043_at

2491521

2562200

2562201

2562202

2562203

2562204

2562205

2562209

2562210

2562211

2562212

2562213

2562214

2562215

2562216

2562217

2562218

2562220

2562221

2562222

2562224

2562226

2562228

2562230

31827_s_at

31828_r_at

31829_r_at

38993_r_at

8053388

A_23_P209933

A_24_P413988

GE81643

GE86506

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005783

GO:0005788

GO:0005794

GO:0005802

GO:0005886

GO:0006464

GO:0008150

GO:0016020

GO:0016021

GO:0030133

GO:0030140

GO:0030665

GO:0031410

GO:0043226

GO:0043687

GO:0044267

GO:0061024

Hs.110771.0.S1_3p_x_at

Hs.110771.0.S2_3p_at

Hs.14894.0.S1_3p_a_at

Hs.14894.0.S1_3p_s_at

ILMN_1651735

PH_hs_0001402

PH_hs_0040170

TC02002035.hg

X94333_at

g5454115_3p_a_at

Participant Of

hasCandidate

Golgi-associated Vesicle Cargo [cytoplasmic vesicle membrane]

Other forms of this molecule

TGOLN2 [endoplasmic reticulum lumen]

p-TGOLN2 [endoplasmic reticulum lumen]

TGOLN2 [transport vesicle]

TGOLN2 [trans-Golgi network membrane]

TGOLN2 [Golgi membrane]

TGOLN2 [plasma membrane]

TGOLN2 [clathrin-coated endocytic vesicle membrane]

Inferred To

Ttgn1 [cytoplasmic vesicle membrane] (Rattus norvegicus)

TGOLN2 [cytoplasmic vesicle membrane] (Canis familiaris)

TGOLN2 [cytoplasmic vesicle membrane] (Gallus gallus)

Tgoln1 [cytoplasmic vesicle membrane] (Mus musculus)

Cross References

RefSeq

NP_001193773.1, NP_001193770.1, NP_001193769.1, NP_006455.2

OpenTargets

ENSG00000152291

HPA

ENSG00000152291-TGOLN2

GeneCards

O43493

Ensembl

ENST00000398263, ENST00000377386, ENSP00000366603, ENSP00000387035, ENST00000444342, ENST00000409015, ENSG00000152291, ENSP00000391190, ENSP00000381312

PRO

O43493

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H3P7 ACBD3	1	ACBD3 [Golgi membrane] (R-HSA-8874981)	0.577	5
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789)	0.564	2
UniProt:Q9NZ52 GGA3	3	GGA3 [recycling endosome membrane] (R-HSA-8875655) GGA3 [endosome membrane] (R-HSA-5692936) GGA3 [early endosome membrane] (R-HSA-8854137)	0.491	3
UniProt:Q14677 CLINT1	1	CLINT1 [cytosol] (R-HSA-429811)	0.462	4
UniProt:Q07065 CKAP4	7	PALM-C100-CKAP4 [plasma membrane] (R-HSA-5686280) PALM-C100-CKAP4 [lamellar body] (R-HSA-5686285) CKAP4 [specific granule membrane] (R-HSA-6799552) CKAP4 [plasma membrane] (R-HSA-5686306) CKAP4 [azurophil granule membrane] (R-HSA-6799559) p-CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956926) CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956737)	0.462	2
UniProt:Q9H2J7 SLC6A15	1	SLC6A15 [plasma membrane] (R-HSA-352060)	0.462	4
UniProt:Q04721 NOTCH2	18	NOTCH2(1666-1696) [plasma membrane] (R-HSA-157628) NOTCH2(1582-1665) [extracellular region] (R-HSA-157652) NEXT2 [plasma membrane] (R-HSA-157225) NICD2 [cytosol] (R-HSA-157642) NICD2 [nucleoplasm] (R-HSA-157942) Glc,GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911428) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911417) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911505) FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) [plasma membrane] (R-HSA-1911518) FRINGE-modified NOTCH2 extracellular fragment (NECD2) [Golgi membrane] (R-HSA-1911520) Pre-NOTCH2 [endoplasmic reticulum membrane] (R-HSA-157025) 18xFucT-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467363) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467379) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [Golgi membrane] (R-HSA-1472874) NOTCH2(1582-2471) [plasma membrane] (R-HSA-157228) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [extracellular region] (R-HSA-1983678) NOTCH2(1582-2471) [Golgi membrane] (R-HSA-157017) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [Golgi membrane] (R-HSA-1983676)	0.462	2
UniProt:Q14739 LBR	2	LBR [nuclear envelope] (R-HSA-194637) p-S71,S86-LBR [nuclear envelope] (R-HSA-9624811)	0.462	2
UniProt:Q9NZC7 WWOX	1	WWOX [cytosol] (R-HSA-1253335)	0.462	2
UniProt:P35613 BSG	2	BSG [Golgi membrane] (R-HSA-204478) BSG [plasma membrane] (R-HSA-197673)	0.462	2

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