Reactome | EXOSC1 [cytosol]

EXOSC1 [cytosol]

Stable Identifier

R-HSA-429841

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

3'-5' exoribonuclease CSL4 homolog, EXOS1_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Unfolded Protein Response (UPR) (Homo sapiens)
    - PERK regulates gene expression (Homo sapiens)
      - ATF4 activates genes in response to endoplasmic reticulum stress (Homo sapiens)
        
        Expression of IL-8 (Homo sapiens)
        
        KSRP:mRNA Degradation Complex [cytosol] (Homo sapiens)
        
        Exosome Complex [cytosol] (Homo sapiens)
        
        EXOSC1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y3B2 EXOSC1

Gene Names

EXOSC1, CSL4, CGI-108

Chain

chain:1-195

Reference Genes

BioGPS Gene:51013 EXOSC1

COSMIC (genes):EXOSC1 EXOSC1

CTD Gene:51013 EXOSC1

dbSNP Gene:51013 EXOSC1

ENSEMBL:ENSG00000171311 EXOSC1

ENSEMBL_homo_sapiens_GENE:ENSG00000171311.13 EXOSC1

HGNC:17286 EXOSC1

KEGG Gene (Homo sapiens):51013 EXOSC1

Monarch:51013 EXOSC1

NCBI Gene:51013 EXOSC1

OMIM:606493 EXOSC1

UCSC:Q9Y3B2 EXOSC1

Reference Transcript

Other Identifiers

11756515_s_at

222609_PM_s_at

222609_s_at

3302332

3302333

3302334

3302336

3302338

3302339

3302341

3302342

3302348

3302350

51013

56575_at

7935462

A_23_P35591

GE58663

GO:0000176

GO:0000177

GO:0000178

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006364

GO:0006396

GO:0006401

GO:0042254

GO:0043226

GO:0101019

HMNXSV003056863

Hs.14415.0.S1_3p_a_at

ILMN_1677483

ILMN_2396648

PH_hs_0027080

TC10001566.hg

Participates

as a component of

Exosome Complex [cytosol] (Homo sapiens)

Other forms of this molecule

EXOSC1 [nucleoplasm]

Inferred To

csl4 [cytosol] (Schizosaccharomyces pombe)

EXOSC1 [cytosol] (Bos taurus)

EXOSC1 [cytosol] (Canis familiaris)

EXOSC1 [cytosol] (Dictyostelium discoideum)

EXOSC1 [cytosol] (Gallus gallus)

EXOSC1 [cytosol] (Sus scrofa)

CSL4 [cytosol] (Saccharomyces cerevisiae)

Exosc1 [cytosol] (Mus musculus)

Exosc1 [cytosol] (Rattus norvegicus)

Csl4 [cytosol] (Drosophila melanogaster)

exosc1 [cytosol] (Xenopus tropicalis)

exos-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001305291.1, NP_001305294.1, NP_001305292.1, NP_001305295.1, NP_001305293.1, NP_057130.1

OpenTargets

ENSG00000171311

GeneCards

Q9Y3B2

HPA

ENSG00000171311-EXOSC1

Ensembl

ENSG00000171311, ENST00000370902, ENSP00000359939

PRO

Q9Y3B2

Pharos - Targets

Q9Y3B2

PDB

2NN6, 6D6R, 6H25, 6D6Q

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NQT4 EXOSC5	2	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550)	0.972	33
UniProt:Q01780 EXOSC10	1	EXOSC10 [nucleoplasm] (R-HSA-6791547)	0.758	4
UniProt:Q719H9 KCTD1	1	KCTD1 [nucleoplasm] (R-HSA-8864339)	0.718	6
UniProt:P52747 ZNF143	1	ZNF143 [nucleoplasm] (R-HSA-83837)	0.556	3
UniProt:Q9Y580 RBM7	1	RBM7 [nucleoplasm] (R-HSA-8985564)	0.527	2
UniProt:Q13901 C1D	1	C1D [nucleoplasm] (R-HSA-6791515)	0.527	2