Reactome: A Curated Pathway Database

DCP1-DCP2 complex decaps mRNA

Stable Identifier
R-HSA-429860
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The DCP1-DCP2 decapping complex binds the 7-methylguanosine cap of mRNA and hydrolyzes the triphosphate bond to yield 7-methylguanosine 5'-diphosphate and RNA with 5'-monophosphate. The DCP2 subunit of the complex catalyzes the hydrolysis. DCP2 has higher affinity for some subsets of mRNA.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
exoribonuclease activity, producing 5'-phosphomonoesters of DCP1-DCP2 Decapping Complex [cytosol] DCP1-DCP2 Decapping Complex [cytosol] exoribonuclease activity, producing 5'-phosphomonoesters (0016896)
Orthologous Events