DCP1-DCP2 complex decaps mRNA

Stable Identifier
R-HSA-429860
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The DCP1-DCP2 decapping complex binds the 7-methylguanosine cap of mRNA and hydrolyzes the triphosphate bond to yield 7-methylguanosine 5'-diphosphate and RNA with 5'-monophosphate. The DCP2 subunit of the complex catalyzes the hydrolysis. DCP2 has higher affinity for some subsets of mRNA.

Literature References
PubMed ID Title Journal Year
15475613 Messenger RNA decay in mammalian cells: the exonuclease perspective

Fritz, DT, Bergman, N, Kilpatrick, WJ, Wilusz, CJ, Wilusz, J

Cell Biochem Biophys 2004
16141059 From birth to death: the complex lives of eukaryotic mRNAs

Moore, MJ

Science 2005
16246173 Decapping the message: a beginning or an end

Liu, H, Kiledjian, M

Biochem Soc Trans 2006
15085179 Poly(A)-binding-protein-mediated regulation of hDcp2 decapping in vitro

Khanna, R, Kiledjian, M

EMBO J 2004
12486012 Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures

van Dijk, E, Cougot, N, Meyer, S, Babajko, S, Wahle, E, Séraphin, B

EMBO J 2002
11283721 The cap-to-tail guide to mRNA turnover

Wilusz, CJ, Wormington, M, Peltz, SW

Nat Rev Mol Cell Biol 2001
14749774 The enzymes and control of eukaryotic mRNA turnover

Parker, R, Song, H

Nat Struct Mol Biol 2004
12923261 Functional characterization of the mammalian mRNA decapping enzyme hDcp2

Piccirillo, C, Khanna, R, Kiledjian, M

RNA 2003
12218187 The hDcp2 protein is a mammalian mRNA decapping enzyme

Wang, Z, Jiao, X, Carr-Schmid, A, Kiledjian, M

Proc Natl Acad Sci U S A 2002
12417715 Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay

Lykke-Andersen, J

Mol Cell Biol 2002
18039849 Transcript-specific decapping and regulated stability by the human Dcp2 decapping protein

Li, Y, Song, MG, Kiledjian, M

Mol Cell Biol 2008
19239894 The many pathways of RNA degradation

Houseley, J, Tollervey, D

Cell 2009
17245413 The highways and byways of mRNA decay

Garneau, NL, Wilusz, J, Wilusz, CJ

Nat Rev Mol Cell Biol 2007
19061636 The control of mRNA decapping and P-body formation

Franks, TM, Lykke-Andersen, J

Mol Cell 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
exoribonuclease activity, producing 5'-phosphomonoesters of DCP1-DCP2 Decapping Complex [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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