Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
CNOT1 [cytosol]
Stable Identifier
R-HSA-429892
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CCR4-NOT transcription complex subunit 1, CNOT1_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Maternal to zygotic transition (MZT) (Homo sapiens)
M-decay: degradation of maternal mRNAs by maternally stored factors (Homo sapiens)
BTG4 binds CNOT7 of the CCR4-NOT complex, PABPN1L, and eIF4E of the mRNP (Homo sapiens)
CCR4-NOT Complex (CNOT7) [cytosol] (Homo sapiens)
CNOT1 [cytosol] (Homo sapiens)
CCR4-NOT:BTG4:PABPN1L:mRNP [cytosol] (Homo sapiens)
CCR4-NOT Complex (CNOT7) [cytosol] (Homo sapiens)
CNOT1 [cytosol] (Homo sapiens)
CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP (Homo sapiens)
CCR4-NOT:BTG4:PABPN1L:deadenylated mRNP [cytosol] (Homo sapiens)
CCR4-NOT Complex (CNOT7) [cytosol] (Homo sapiens)
CNOT1 [cytosol] (Homo sapiens)
CCR4-NOT:BTG4:PABPN1L:mRNP [cytosol] (Homo sapiens)
CCR4-NOT Complex (CNOT7) [cytosol] (Homo sapiens)
CNOT1 [cytosol] (Homo sapiens)
CCR4-NOT(CNOT6L) deadenylates mRNA in CCR4-NOT(CNOT6L):ZFP36L2:mRNA (Homo sapiens)
CCR4-NOT(CNOT6L):ZFP36L2:deadenylated mRNA [cytosol] (Homo sapiens)
CCR4-NOT Complex (CNOT6L) [cytosol] (Homo sapiens)
CNOT1 [cytosol] (Homo sapiens)
CCR4-NOT(CNOT6L):ZFP36L2:mRNA [cytosol] (Homo sapiens)
CCR4-NOT Complex (CNOT6L) [cytosol] (Homo sapiens)
CNOT1 [cytosol] (Homo sapiens)
ZFP36L2 binds CNOT6L of CCR4-CNOT complex and an AU-rich element in mRNA (Homo sapiens)
CCR4-NOT Complex (CNOT6L) [cytosol] (Homo sapiens)
CNOT1 [cytosol] (Homo sapiens)
CCR4-NOT(CNOT6L):ZFP36L2:mRNA [cytosol] (Homo sapiens)
CCR4-NOT Complex (CNOT6L) [cytosol] (Homo sapiens)
CNOT1 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
BTG2 binds CCR4-NOT complex (Homo sapiens)
BTG2:CCR4-NOT [cytosol] (Homo sapiens)
CCR4-NOT Complex [cytosol] (Homo sapiens)
CNOT1 [cytosol] (Homo sapiens)
CCR4-NOT Complex [cytosol] (Homo sapiens)
CNOT1 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Deadenylation-dependent mRNA decay (Homo sapiens)
Deadenylation of mRNA (Homo sapiens)
CCR4-NOT complex deadenylates mRNA (Homo sapiens)
CCR4-NOT Complex [cytosol] (Homo sapiens)
CNOT1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:A5YKK6 CNOT1
Gene Names
CNOT1, CDC39, KIAA1007, NOT1, AD-005
Chain
chain:1-2376
Reference Genes
BioGPS Gene:23019 CNOT1
COSMIC (genes):CNOT1 CNOT1
CTD Gene:23019 CNOT1
dbSNP Gene:23019 CNOT1
ENSEMBL:ENSG00000125107 CNOT1
ENSEMBL_homo_sapiens_GENE:ENSG00000125107.19 CNOT1
HGNC:7877 CNOT1
KEGG Gene (Homo sapiens):23019 CNOT1
Monarch:23019 CNOT1
NCBI Gene:23019 CNOT1
OMIM:604917 CNOT1
UCSC:A5YKK6 CNOT1
Reference Transcript
RefSeq:NM_016284.4 CNOT1
RefSeq:NM_001265612.1 CNOT1
RefSeq:NM_206999.2 CNOT1
Other Identifiers
11717590_a_at
11717591_s_at
11730655_a_at
11749878_a_at
1554052_PM_at
1554052_at
16826909
200860_PM_s_at
200860_s_at
200861_PM_at
200861_at
23019
3693672
3693674
3693675
3693676
3693677
3693678
3693680
3693682
3693685
3693686
3693687
3693688
3693689
3693692
3693693
3693694
3693696
3693697
3693699
3693700
3693701
3693702
3693703
3693704
3693705
3693706
3693707
3693708
3693709
3693710
3693711
3693712
3693713
3693714
3693716
3693717
3693718
3693719
3693720
3693721
3693722
3693723
3693724
3693725
3693726
3693728
3693730
3693731
3693732
3693733
3693734
3693735
3693737
3693738
3693739
3693740
3693741
3693742
3693743
3693744
3693745
3693746
3693747
3693749
3693754
3693755
3693765
41727_at
8001693
A_23_P77371
A_24_P101114
A_24_P193570
GE63184
GO:0000122
GO:0000288
GO:0000289
GO:0000932
GO:0001829
GO:0003723
GO:0003824
GO:0004535
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005777
GO:0005778
GO:0005829
GO:0006351
GO:0006355
GO:0006417
GO:0010606
GO:0016020
GO:0016071
GO:0016787
GO:0017148
GO:0019904
GO:0023052
GO:0030014
GO:0030015
GO:0030154
GO:0030331
GO:0031047
GO:0033147
GO:0035195
GO:0042974
GO:0043226
GO:0048387
GO:0048856
GO:0060090
GO:0060213
GO:0061014
GO:0070016
GO:0140098
GO:1900153
GO:2000036
HMNXSV003024892
HMNXSV003027164
Hs2.279949.2.S1_3p_at
ILMN_1669206
ILMN_1677840
ILMN_1682501
PH_hs_0014432
TC16001154.hg
g12653966_3p_a_at
g7706213_3p_at
Participates
as a component of
CCR4-NOT Complex (CNOT6L) [cytosol] (Homo sapiens)
CCR4-NOT Complex (CNOT7) [cytosol] (Homo sapiens)
CCR4-NOT Complex [cytosol] (Homo sapiens)
Inferred To
Cnot1 [cytosol]
(Mus musculus)
Cnot1 [cytosol]
(Rattus norvegicus)
CNOT1 [cytosol]
(Bos taurus)
CNOT1 [cytosol]
(Canis familiaris)
CNOT1 [cytosol]
(Gallus gallus)
CNOT1 [cytosol]
(Sus scrofa)
DG1040 [cytosol]
(Dictyostelium discoideum)
cnot1 [cytosol]
(Danio rerio)
cnot1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_996882.1
,
NP_057368.3
,
NP_001252541.1
OpenTargets
ENSG00000125107
HPA
ENSG00000125107-CNOT1
GeneCards
A5YKK6
Ensembl
ENST00000441024
,
ENSP00000413113
,
ENSG00000125107
,
ENST00000569240
,
ENSP00000320949
,
ENST00000317147
,
ENSP00000455635
,
ENST00000567188
,
ENSP00000456649
PRO
A5YKK6
Pharos - Targets
A5YKK6
Orphanet
28665
PDB
5FU7
,
4CT6
,
5FU6
,
4C0D
,
4CRW
,
4GML
,
4GMJ
,
4CT7
,
4CQO
,
5ONA
,
8FY3
,
8BFI
,
5ANR
,
4J8S
,
7VOI
,
4CRV
,
4CT4
,
4CRU
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22893
2
phospho-Zfp36 [cytosol]
(R-MMU-450496)
Zfp36 [cytosol]
(R-MMU-450562)
0.558
5
UniProt:Q8NDV7 TNRC6A
2
TNRC6A [nucleoplasm]
(R-HSA-5578976)
TNRC6A [cytosol]
(R-HSA-427769)
0.499
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
8
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text