Reactome | CNOT2 [cytosol]

CNOT2 [cytosol]

Stable Identifier

R-HSA-429902

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CCR4-NOT transcription complex subunit 2, CNOT2_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        BTG2 binds CCR4-NOT complex (Homo sapiens)
        
        BTG2:CCR4-NOT [cytosol] (Homo sapiens)
        
        CCR4-NOT Complex [cytosol] (Homo sapiens)
        
        CNOT2 [cytosol] (Homo sapiens)
        
        CCR4-NOT Complex [cytosol] (Homo sapiens)
        
        CNOT2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NZN8 CNOT2

Gene Names

CNOT2, CDC36, NOT2, HSPC131, MSTP046

Chain

chain:1-540

Reference Genes

BioGPS Gene:4848 CNOT2

COSMIC (genes):CNOT2 CNOT2

CTD Gene:4848 CNOT2

dbSNP Gene:4848 CNOT2

ENSEMBL:ENSG00000111596 CNOT2

HGNC:7878 CNOT2

KEGG:hsa:4848 CNOT2

Monarch:4848 CNOT2

NCBI Gene:4848 CNOT2

OMIM:604909 CNOT2

UCSC:Q9NZN8 CNOT2

Reference Transcript

Other Identifiers

11734936_a_at

11734937_a_at

11757803_x_at

16754060

217798_PM_at

217798_at

222182_PM_s_at

222182_s_at

233054_PM_at

233054_at

3275276

33861_at

3421902

3421903

3421904

3421905

3421906

3421907

3421908

3421909

3421910

3421911

3421912

3421913

3421921

3421922

3421923

3421927

3421929

3421930

3421932

3421934

3421936

3421937

3421939

3421943

3421944

3421945

3421946

3421947

3421948

3421949

3421950

3421951

3421952

3421953

3421954

3421955

3421956

3421957

3421958

3421959

3421960

3421961

3421962

3421963

3421964

3421965

3421966

3421967

3421968

3421969

3421970

3421972

3421973

3421974

3421975

3421976

3421977

3421978

4848

72303_at

7893598

7895969

7957106

90977_at

A_14_P102198

A_14_P106545

A_14_P121407

A_19_P00328397

A_23_P162336

A_23_P421147

A_24_P8049

A_24_P942296

A_33_P3287690

GE81936

GO:0000122

GO:0000289

GO:0000932

GO:0001222

GO:0001829

GO:0003712

GO:0003824

GO:0004535

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006355

GO:0006357

GO:0006417

GO:0010606

GO:0016020

GO:0016071

GO:0016787

GO:0030014

GO:0030015

GO:0030154

GO:0031047

GO:0033147

GO:0043226

GO:0060090

GO:0140098

GO:0140110

GO:2000036

HMNXSV003024520

HMNXSV003025484

Hs.239720.0.S2_3p_at

Hs.239720.2.S1_3p_at

ILMN_1772651

PH_hs_0031951

TC12000620.hg

TC12002443.hg

Participates

as a component of

Inferred To

Ghost homologue of CNOT2 [cytosol] (Canis familiaris)

Ghost homologue of CNOT2 [cytosol] (Danio rerio)

Cnot2 [cytosol] (Mus musculus)

Cnot2 [cytosol] (Rattus norvegicus)

cnot2 [cytosol] (Xenopus tropicalis)

CNOT2 [cytosol] (Bos taurus)

CNOT2 [cytosol] (Dictyostelium discoideum)

CNOT2 [cytosol] (Gallus gallus)

CNOT2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001186232.1, NP_001186231.1, NP_055330.1, XP_011536701.1

ENSEMBL

ENST00000418359, ENSP00000412091, ENSP00000449260, ENST00000229195, ENST00000551483, ENSP00000229195, ENST00000551043, ENSP00000448883

OpenTargets

ENSG00000111596

HPA

ENSG00000111596-CNOT2

PRO

Q9NZN8

Pharos - Targets

Q9NZN8

GlyGen

Q9NZN8

Orphanet

CNOT2

PDB

5FU7, 4C0D, 5FU6, 4C0F

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13207 TBX2	1	TBX2 [nucleoplasm] (R-HSA-9825814)	0.556	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.556	3
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.556	3
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.556	3
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.527	3
UniProt:Q9UBE8 NLK	3	NLK [cytosol] (R-HSA-4411330) p-T298-NLK [cytosol] (R-HSA-4411398) p-T298-NLK [nucleoplasm] (R-HSA-4411376)	0.527	2
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.527	3
UniProt:Q92600 RQCD1	2	RQCD1 [nucleoplasm] (R-HSA-6810130) RQCD1 [cytosol] (R-HSA-430029)	0.508	2