DCPS scavenges the 7-methylguanosine cap of mRNA

Stable Identifier
Reaction [transition]
Homo sapiens
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The scavenging nuclease DCPS hydrolyzes the triphosphate bond between the 7-methylguanosine cap and the remaining oligoribonucleotide body of the mRNA. The products are 7-methylguanosine 5'-monophosphate and an oligoribonucleotide with a 5'-diphosphate.
Literature References
PubMed ID Title Journal Year
14749774 The enzymes and control of eukaryotic mRNA turnover

Song, H, Parker, R

Nat Struct Mol Biol 2004
16141059 From birth to death: the complex lives of eukaryotic mRNAs

Moore, MJ

Science 2005
18441014 Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme

Liu, SW, Kiledjian, M, Patel, SS, Rajagopal, V

J Biol Chem 2008
15475613 Messenger RNA decay in mammalian cells: the exonuclease perspective

Fritz, DT, Wilusz, J, Bergman, N, Wilusz, CJ, Kilpatrick, WJ

Cell Biochem Biophys 2004
15769464 Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping

Chen, N, Liu, Y, Song, H, Walsh, MA, Parker, R

J Mol Biol 2005
15273322 Functional analysis of mRNA scavenger decapping enzymes

Jiao, X, Liu, SW, Kiledjian, M, Liu, H, Lima, CD, Gu, M

RNA 2004
19239894 The many pathways of RNA degradation

Houseley, J, Tollervey, D

Cell 2009
17245413 The highways and byways of mRNA decay

Garneau, NL, Wilusz, J, Wilusz, CJ

Nat Rev Mol Cell Biol 2007
15068804 Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity

Fabrega, C, Liu, SW, Kiledjian, M, Liu, H, Lima, CD, Gu, M

Mol Cell 2004
11283721 The cap-to-tail guide to mRNA turnover

Wormington, M, Wilusz, CJ, Peltz, SW

Nat Rev Mol Cell Biol 2001
Catalyst Activity

RNA exonuclease activity of DCPS [cytosol]

Orthologous Events
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