Lsm1-7 Complex binds deadenylated mRNA

Stable Identifier
R-HSA-429978
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The Lsm1-7 complex forms a heptameric ring that binds the 3' oligoadenylated ends of mRNAs that have been deadenylated. The bound Lsm1-7 may prevent access of the exosome (a 3' to 5' exonuclease) to the 3' end and thereby direct the mRNA to the 5' to 3' exonuclease pathway. The yeast Lsm1-7 complex has a preference for oligoadenylated RNA compared to polyadenylated RNA, however other determinants of binding by Lsm1-7 are unknown.

Participants
Participant Of
Orthologous Events