Lsm1-7 Complex binds deadenylated mRNA

Stable Identifier
R-HSA-429978
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The Lsm1-7 complex forms a heptameric ring that binds the 3' oligoadenylated ends of mRNAs that have been deadenylated. The bound Lsm1-7 may prevent access of the exosome (a 3' to 5' exonuclease) to the 3' end and thereby direct the mRNA to the 5' to 3' exonuclease pathway. The yeast Lsm1-7 complex has a preference for oligoadenylated RNA compared to polyadenylated RNA, however other determinants of binding by Lsm1-7 are unknown.

Literature References
PubMed ID Title Journal Year
16141059 From birth to death: the complex lives of eukaryotic mRNAs

Moore, MJ

Science 2005
14749774 The enzymes and control of eukaryotic mRNA turnover

Parker, R, Song, H

Nat Struct Mol Biol 2004
15475613 Messenger RNA decay in mammalian cells: the exonuclease perspective

Fritz, DT, Bergman, N, Kilpatrick, WJ, Wilusz, CJ, Wilusz, J

Cell Biochem Biophys 2004
15711010 Reconstitution of two recombinant LSm protein complexes reveals aspects of their architecture, assembly, and function

Zaric, B, Chami, M, Rémigy, H, Engel, A, Ballmer-Hofer, K, Winkler, FK, Kambach, C

J Biol Chem 2005
16051491 LSm proteins form heptameric rings that bind to RNA via repeating motifs

Khusial, P, Plaag, R, Zieve, GW

Trends Biochem Sci 2005
19239894 The many pathways of RNA degradation

Houseley, J, Tollervey, D

Cell 2009
17245413 The highways and byways of mRNA decay

Garneau, NL, Wilusz, J, Wilusz, CJ

Nat Rev Mol Cell Biol 2007
15231747 A protein interaction framework for human mRNA degradation

Lehner, B, Sanderson, CM

Genome Res 2004
11283721 The cap-to-tail guide to mRNA turnover

Wilusz, CJ, Wormington, M, Peltz, SW

Nat Rev Mol Cell Biol 2001
19279404 Lsm1-7-Pat1 complex: A link between 3' and 5'-ends in mRNA decay?

Tharun, S

RNA Biol 2009
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