Reactome | PARN [cytosol]

PARN [cytosol]

Stable Identifier

R-HSA-430009

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Poly(A)-specific ribonuclease PARN, PARN_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Unfolded Protein Response (UPR) (Homo sapiens)
    - PERK regulates gene expression (Homo sapiens)
      - ATF4 activates genes in response to endoplasmic reticulum stress (Homo sapiens)
        
        Expression of IL-8 (Homo sapiens)
        
        KSRP:mRNA Degradation Complex [cytosol] (Homo sapiens)
        
        PARN [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95453 PARN

Gene Names

PARN, DAN

Chain

chain:1-639

Reference Genes

BioGPS Gene:5073 PARN

COSMIC (genes):PARN PARN

CTD Gene:5073 PARN

dbSNP Gene:5073 PARN

ENSEMBL:ENSG00000140694 PARN

ENSEMBL_homo_sapiens_GENE:ENSG00000140694.18 PARN

ENSEMBL_homo_sapiens_GENE:ENSG00000274829.4 PARN

HGNC:8609 PARN

KEGG Gene (Homo sapiens):5073 PARN

Monarch:5073 PARN

NCBI Gene:5073 PARN

OMIM:604212 PARN

UCSC:O95453 PARN

Reference Transcript

Other Identifiers

11720492_a_at

11750729_a_at

11753483_a_at

16824082

203905_PM_at

203905_at

36003_at

3681399

3681400

3681401

3681404

3681410

3681426

3681427

3681428

3681430

3681433

3681434

3681435

3681436

3681439

3681440

3681445

3681446

3681447

3681449

3681451

3681453

3681454

3681456

3681457

3681458

3681460

3681462

3681463

5073

7999562

A_23_P113026

A_24_P147190

GE55163

GO:0000184

GO:0000289

GO:0000495

GO:0003676

GO:0003723

GO:0003730

GO:0003824

GO:0004518

GO:0004527

GO:0004535

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006402

GO:0007292

GO:0009451

GO:0010587

GO:0016071

GO:0016607

GO:0016787

GO:0019901

GO:0022414

GO:0032200

GO:0032212

GO:0043169

GO:0043226

GO:0046872

GO:0051973

GO:0070034

GO:0071051

GO:0090669

GO:0098794

GO:0098978

GO:0110008

GO:0140098

GO:1904872

HMNXSV003018303

ILMN_1724811

PH_hs_0003161

TC16000884.hg

g4505610_3p_at

Participates

as an input of

KSRP recruits RNA degradation activities (Homo sapiens)

as a component of

Inferred To

PARN [cytosol] (Bos taurus)

PARN [cytosol] (Canis familiaris)

PARN [cytosol] (Gallus gallus)

PARN [cytosol] (Mus musculus)

PARN [cytosol] (Sus scrofa)

Parn [cytosol] (Rattus norvegicus)

parn [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001229921.1, NP_001127949.1, NP_002573.1

OpenTargets

ENSG00000140694

IntEnz

3.1.13.4

HPA

ENSG00000140694-PARN

GeneCards

O95453

Ensembl

ENST00000420015, ENSG00000274829, ENSG00000140694, ENST00000618929, ENSP00000444381, ENST00000615183, ENST00000437198, ENSP00000387911, ENST00000341484, ENSP00000478668, ENST00000539279, ENST00000631868, ENSP00000345456, ENSP00000488554, ENST00000634004, ENSP00000487634, ENSP00000410525, ENSP00000484279

PRO

O95453

Pharos - Targets

O95453

Orphanet

23221

PDB

2A1S, 3CTR, 2A1R

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.643	4
UniProt:Q99728 BARD1	13	BARD1 G623E [nucleoplasm] (R-HSA-9699135) BARD1 C71Y [nucleoplasm] (R-HSA-9700808) BARD1 C53W [nucleoplasm] (R-HSA-9700807) BARD1 G623W [nucleoplasm] (R-HSA-9699148) BARD1 W34R [nucleoplasm] (R-HSA-9699166) BARD1 H68Y [nucleoplasm] (R-HSA-9699151) BARD1 L44R [nucleoplasm] (R-HSA-9699126) BARD1 C50G [nucleoplasm] (R-HSA-9699137) BARD1 C83G [nucleoplasm] (R-HSA-9699139) K6PolyUb-BARD1 [nucleoplasm] (R-HSA-9701024) K6PolyUb,p-T714,T734-BARD1 [nucleoplasm] (R-HSA-9707286) p-T714,T734-BARD1 [nucleoplasm] (R-HSA-5659846) BARD1 [nucleoplasm] (R-HSA-5659775)	0.577	4
UniProt:O75386 TULP3	1	TULP3 [cilium] (R-HSA-5610445)	0.527	2
UniProt:Q15561 TEAD4	1	TEAD4 [nucleoplasm] (R-HSA-2032780)	0.527	2
UniProt:Q02539 H1-1	1	HIST1H1A [nucleoplasm] (R-HSA-211245)	0.527	2
UniProt:Q2NL82 TSR1	2	TSR1 [nucleoplasm] (R-HSA-6791574) TSR1 [cytosol] (R-HSA-6791570)	0.527	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.525	2
UniProt:P33240 CSTF2	1	CSTF2 [nucleoplasm] (R-HSA-72003)	0.499	5