Reactome | DDX6 [cytosol]

DDX6 [cytosol]

Stable Identifier

R-HSA-430032

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Probable ATP-dependent RNA helicase DDX6, DDX6_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P26196 DDX6

Gene Names

DDX6, HLR2, RCK

Chain

chain:1-483

Reference Genes

BioGPS Gene:1656 DDX6

COSMIC (genes):DDX6 DDX6

CTD Gene:1656 DDX6

dbSNP Gene:1656 DDX6

ENSEMBL:ENSG00000110367 DDX6

HGNC:2747 DDX6

KEGG:hsa:1656 DDX6

Monarch:1656 DDX6

NCBI Gene:1656 DDX6

OMIM:600326 DDX6

UCSC:P26196 DDX6

Reference Transcript

Other Identifiers

11718967_at

11718968_a_at

11718969_a_at

1656

16745085

204909_PM_at

204909_at

225549_PM_at

225549_at

2947762

2947768

3393943

3393945

3393947

3393948

3393949

3393950

3393951

3393952

3393953

3393954

3393955

3393956

3393957

3393959

3393960

3393961

3393962

3393963

3393964

3393970

3393971

3393972

3393973

3393974

3393975

3393976

3393978

3393979

3393982

3495819

3495822

36283_at

52993_at

70792_at

7952103

A_23_P203201

A_24_P215407

D17532_at

GE57104

GE86447

GE86532

GO:0000932

GO:0003676

GO:0003723

GO:0003724

GO:0003729

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005786

GO:0005829

GO:0006617

GO:0010494

GO:0016020

GO:0016442

GO:0016787

GO:0016887

GO:0017148

GO:0019074

GO:0019827

GO:0019904

GO:0030154

GO:0030182

GO:0031047

GO:0033962

GO:0034063

GO:0035278

GO:0036464

GO:0043226

GO:0045296

GO:0045665

GO:0065003

GO:0140098

GO:0140657

HMNXSV003003073

Hs.271541.0.S1_3p_at

ILMN_1777340

PH_hs_0023351

PH_hs_0032397

TC11002353.hg

TC11003376.hg

Z11685_s_at

g13514828_3p_at

Participates

as a component of

DCP1-DCP2 Decapping Complex [cytosol] (Homo sapiens)

Inferred To

Ddx6 [cytosol] (Rattus norvegicus)

DDX6 [cytosol] (Bos taurus)

DDX6 [cytosol] (Caenorhabditis elegans)

DDX6 [cytosol] (Canis familiaris)

DDX6 [cytosol] (Dictyostelium discoideum)

DDX6 [cytosol] (Drosophila melanogaster)

DDX6 [cytosol] (Gallus gallus)

DDX6 [cytosol] (Mus musculus)

DDX6 [cytosol] (Plasmodium falciparum)

DDX6 [cytosol] (Saccharomyces cerevisiae)

DDX6 [cytosol] (Sus scrofa)

DDX6 [cytosol] (Xenopus tropicalis)

ddx6 [cytosol] (Danio rerio)

Cross References

OpenTargets

ENSG00000110367

ENSEMBL

ENSG00000110367, ENSP00000442266, ENSP00000478754, ENST00000620157, ENST00000526070, ENSP00000433704, ENST00000534980

GeneCards

DDX6

HPA

ENSG00000110367-DDX6

PRO

P26196

Pharos - Targets

P26196

GlyGen

P26196

Orphanet

DDX6

HMDB Protein

HMDBP11693

PDB

6F9S, 5ANR, 6S8S, 2WAX, 4CRW, 4CT4, 2WAY, 1VEC, 4CT5

Interactors (60)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.925	13
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.816	12
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) AGO2 [nucleoplasm] (R-HSA-5578701)	0.808	15
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.781	7
UniProt:Q96CA5 BIRC7	1	BIRC7 [cytosol] (R-HSA-50855)	0.781	7
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.763	5
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.723	10
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.718	6
UniProt:Q92841 DDX17	2	DDX17 [nucleoplasm] (R-HSA-3900090) monoSUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104)	0.666	4
UniProt:Q13123 IK	1	IK [nucleoplasm] (R-HSA-9770239)	0.659	4
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.623	3
UniProt:P62847 RPS24	2	RPS24 [cytosol] (R-HSA-72355) RPS24 [nucleoplasm] (R-HSA-6791186)	0.615	3
UniProt:P62266 RPS23	3	RPS23 [cytosol] (R-HSA-72353) RPS23 [nucleoplasm] (R-HSA-6791209) 3OHP62-RPS23 [nucleoplasm] (R-HSA-9630773)	0.615	3
UniProt:P62263 RPS14	2	RPS14 [cytosol] (R-HSA-72333) RPS14 [nucleoplasm] (R-HSA-6790669)	0.615	3
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.615	5
UniProt:P62280 RPS11	2	RPS11 [cytosol] (R-HSA-72327) RPS11 [nucleoplasm] (R-HSA-6791212)	0.615	3
UniProt:P62917 RPL8	3	RPL8 [cytosol] (R-HSA-72490) RPL8 [nucleoplasm] (R-HSA-9630985) 3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976)	0.615	3
UniProt:P62249 RPS16	2	RPS16 [cytosol] (R-HSA-72337) RPS16 [nucleoplasm] (R-HSA-6791196)	0.615	4
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.615	3
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.615	3
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.615	3
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.595	3
UniProt:Q8NDV7 TNRC6A	2	TNRC6A [nucleoplasm] (R-HSA-5578976) TNRC6A [cytosol] (R-HSA-427769)	0.569	4
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.564	4
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.564	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q9BUH8 BEGAIN	1	BEGAIN [cytosol] (R-HSA-6794250)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.537	5
UniProt:P62318 SNRPD3	3	2xMe-SNRPD3 [cytosol] (R-HSA-191781) 2xMe-SNRPD3 [nucleoplasm] (R-HSA-192219) SNRPD3 [nucleoplasm] (R-HSA-71903)	0.536	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.536	2
UniProt:Q12905 ILF2	5	ILF2 [cytosol] (R-HSA-9836392) ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [specific granule lumen] (R-HSA-6799611)	0.527	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P62241 RPS8	2	RPS8 [cytosol] (R-HSA-72385) RPS8 [nucleoplasm] (R-HSA-6791203)	0.527	2
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.527	3
UniProt:P62081 RPS7	2	RPS7 [cytosol] (R-HSA-72383) RPS7 [nucleoplasm] (R-HSA-6790635)	0.527	2
UniProt:P46776 RPL27A	3	RPL27A [cytosol] (R-HSA-72442) RPL27A [nucleoplasm] (R-HSA-9630984) 3OHH39-RPL27A [nucleoplasm] (R-HSA-9630970)	0.527	2
UniProt:P05455 SSB	1	SSB [nucleoplasm] (R-HSA-58418)	0.483	2
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.483	2
UniProt:P52272 HNRNPM	1	HNRNPM [nucleoplasm] (R-HSA-71949)	0.483	2
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.483	2
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.483	2
UniProt:Q04637 EIF4G1	2	EIF4G1 [cytosol] (R-HSA-72584) p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762)	0.483	2
UniProt:Q9NZI8 IGF2BP1	1	IGF2BP1 [cytosol] (R-HSA-428366)	0.483	2
UniProt:P61247 RPS3A	2	RPS3A [cytosol] (R-HSA-72373) RPS3A [nucleoplasm] (R-HSA-6791182)	0.483	2
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.483	2
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.483	2
UniProt:Q9HD20 ATP13A1	1	ATP13A1 [endoplasmic reticulum membrane] (R-HSA-939749)	0.483	2
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.483	2
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.483	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.483	2
UniProt:P62244 RPS15A	2	RPS15A [cytosol] (R-HSA-72345) RPS15A [nucleoplasm] (R-HSA-6791191)	0.483	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.483	2
UniProt:Q15717 ELAVL1	6	ELAVL1 [nucleoplasm] (R-HSA-450601) p-S158,S221-ELAVL1 [nucleoplasm] (R-HSA-450576) p-S221,S318-ELAVL1 [nucleoplasm] (R-HSA-450532) ELAVL1 [cytosol] (R-HSA-450582) p-S221,S318-ELAVL1 [cytosol] (R-HSA-450448) p-S158,S221-ELAVL1 [cytosol] (R-HSA-450376)	0.483	2
UniProt:P46782 RPS5	2	RPS5 [cytosol] (R-HSA-72379) RPS5 [nucleoplasm] (R-HSA-6791188)	0.483	2

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