Reactome | DDX6 [cytosol]

DDX6 [cytosol]

Stable Identifier

R-HSA-430032

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Probable ATP-dependent RNA helicase DDX6, DDX6_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P26196 DDX6

Gene Names

DDX6, HLR2, RCK

Chain

chain:1-483

Reference Genes

BioGPS Gene:1656 DDX6

COSMIC (genes):DDX6 DDX6

CTD Gene:1656 DDX6

dbSNP Gene:1656 DDX6

ENSEMBL:ENSG00000110367 DDX6

HGNC:2747 DDX6

KEGG Gene (Homo sapiens):1656 DDX6

Monarch:1656 DDX6

NCBI Gene:1656 DDX6

OMIM:600326 DDX6

UCSC:P26196 DDX6

Reference Transcript

Other Identifiers

11718967_at

11718968_a_at

11718969_a_at

1656

16745085

204909_at

225549_at

2947762

2947768

3393943

3393945

3393947

3393948

3393949

3393950

3393951

3393952

3393953

3393954

3393955

3393957

3393959

3393960

3393961

3393964

3393970

3393971

3393973

3393974

3393975

3393978

3393979

3495819

3495822

36283_at

52993_at

70792_at

7952103

A_23_P203201

A_24_P215407

D17532_at

GE57104

GE86447

GE86532

GO:0000003

GO:0000166

GO:0000792

GO:0000932

GO:0001520

GO:0003674

GO:0003676

GO:0003723

GO:0003724

GO:0003729

GO:0004386

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005694

GO:0005730

GO:0005737

GO:0005739

GO:0005829

GO:0005856

GO:0005929

GO:0007283

GO:0008150

GO:0009056

GO:0010494

GO:0016020

GO:0016442

GO:0016787

GO:0016887

GO:0019074

GO:0019827

GO:0019904

GO:0022607

GO:0030154

GO:0032991

GO:0033391

GO:0033962

GO:0034063

GO:0034641

GO:0034655

GO:0036464

GO:0043167

GO:0043226

GO:0043928

GO:0044403

GO:0045296

GO:0045665

GO:0048471

GO:0048515

GO:0048856

GO:0061830

GO:0097227

Hs.271541.0.S1_3p_at

ILMN_1777340

PH_hs_0023351

PH_hs_0032397

TC11002353.hg

TC11003376.hg

Z11685_s_at

g13514828_3p_at

Participant Of

hasComponent

DCP1-DCP2 Decapping Complex [cytosol]

Inferred To

Ddx6 [cytosol] (Mus musculus)

Ddx6 [cytosol] (Rattus norvegicus)

DDX6 [cytosol] (Bos taurus)

DDX6 [cytosol] (Canis familiaris)

DDX6 [cytosol] (Plasmodium falciparum)

DDX6 [cytosol] (Sus scrofa)

Ghost homologue of DDX6 [cytosol] (Gallus gallus)

ddx6 [cytosol] (Danio rerio)

ddx6 [cytosol] (Dictyostelium discoideum)

ddx6 [cytosol] (Xenopus tropicalis)

DHH1 [cytosol] (Saccharomyces cerevisiae)

cgh-1 [cytosol] (Caenorhabditis elegans)

me31B [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_004388.2, NP_001244120.1, XP_005271474.1

OpenTargets

ENSG00000110367

IntEnz

3.6.4.13

GeneCards

P26196

HPA

ENSG00000110367-DDX6

Ensembl

ENSG00000110367, ENST00000534980, ENSP00000442266, ENSP00000433704, ENST00000526070, ENST00000620157, ENSP00000478754

PRO

P26196

Orphanet

28730

HMDB Protein

HMDBP11693

PDB

4CRW, 4CT4, 2WAY, 4CT5, 2WAX, 5ANR, 6S8S, 6F9S, 1VEC

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.842	8
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.718	6
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:P10636-8 MAPT	2	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.641	7
UniProt:P67809 YBX1	2	YBX1 [extracellular region] (R-HSA-9017791) YBX1 [nucleoplasm] (R-HSA-72041)	0.597	5
UniProt:Q9BUH8 BEGAIN	1	BEGAIN [cytosol] (R-HSA-6794250)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.556	3
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.556	3
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:Q92841 DDX17	2	SUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104) DDX17 [nucleoplasm] (R-HSA-3900090)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P10636 MAPT	3	MAPT(2-421) [cytosol] (R-HSA-350628) MAPT(422-758) [cytosol] (R-HSA-350642) MAPT [cytosol] (R-HSA-201574)	0.463	2
UniProt:Q8NDV7 TNRC6A	2	TNRC6A [cytosol] (R-HSA-427769) TNRC6A [nucleoplasm] (R-HSA-5578976)	0.462	3

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