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DDX6 [cytosol]
Stable Identifier
R-HSA-430032
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Probable ATP-dependent RNA helicase DDX6, DDX6_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Deadenylation-dependent mRNA decay (Homo sapiens)
mRNA decay by 5' to 3' exoribonuclease (Homo sapiens)
DCP1-DCP2 complex decaps mRNA (Homo sapiens)
DCP1-DCP2 Decapping Complex [cytosol] (Homo sapiens)
DDX6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P26196 DDX6
Gene Names
DDX6, HLR2, RCK
Chain
chain:1-483
Reference Genes
BioGPS Gene:1656 DDX6
COSMIC (genes):DDX6 DDX6
CTD Gene:1656 DDX6
dbSNP Gene:1656 DDX6
ENSEMBL:ENSG00000110367 DDX6
HGNC:2747 DDX6
KEGG:hsa:1656 DDX6
Monarch:1656 DDX6
NCBI Gene:1656 DDX6
OMIM:600326 DDX6
UCSC:P26196 DDX6
Reference Transcript
RefSeq:XM_005271417.3 DDX6
RefSeq:NM_004397.5 DDX6
RefSeq:NM_001257191.2 DDX6
Other Identifiers
11718967_at
11718968_a_at
11718969_a_at
1656
16745085
204909_PM_at
204909_at
225549_PM_at
225549_at
2947762
2947768
3393943
3393945
3393947
3393948
3393949
3393950
3393951
3393952
3393953
3393954
3393955
3393956
3393957
3393959
3393960
3393961
3393962
3393963
3393964
3393970
3393971
3393972
3393973
3393974
3393975
3393976
3393978
3393979
3393982
3495819
3495822
36283_at
52993_at
70792_at
7952103
A_23_P203201
A_24_P215407
D17532_at
GE57104
GE86447
GE86532
GO:0000932
GO:0003676
GO:0003723
GO:0003724
GO:0003729
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005786
GO:0005829
GO:0006617
GO:0010494
GO:0016020
GO:0016442
GO:0016787
GO:0016887
GO:0017148
GO:0019074
GO:0019827
GO:0019904
GO:0030154
GO:0030182
GO:0031047
GO:0033962
GO:0034063
GO:0035278
GO:0036464
GO:0043226
GO:0045296
GO:0045665
GO:0065003
GO:0140098
GO:0140657
HMNXSV003003073
Hs.271541.0.S1_3p_at
ILMN_1777340
PH_hs_0023351
PH_hs_0032397
TC11002353.hg
TC11003376.hg
Z11685_s_at
g13514828_3p_at
Participates
as a component of
DCP1-DCP2 Decapping Complex [cytosol] (Homo sapiens)
Inferred To
Ddx6 [cytosol]
(Rattus norvegicus)
DDX6 [cytosol]
(Bos taurus)
DDX6 [cytosol]
(Caenorhabditis elegans)
DDX6 [cytosol]
(Canis familiaris)
DDX6 [cytosol]
(Dictyostelium discoideum)
DDX6 [cytosol]
(Drosophila melanogaster)
DDX6 [cytosol]
(Gallus gallus)
DDX6 [cytosol]
(Mus musculus)
DDX6 [cytosol]
(Plasmodium falciparum)
DDX6 [cytosol]
(Saccharomyces cerevisiae)
DDX6 [cytosol]
(Sus scrofa)
DDX6 [cytosol]
(Xenopus tropicalis)
ddx6 [cytosol]
(Danio rerio)
Cross References
OpenTargets
ENSG00000110367
ENSEMBL
ENSG00000110367
,
ENSP00000442266
,
ENSP00000478754
,
ENST00000620157
,
ENST00000526070
,
ENSP00000433704
,
ENST00000534980
GeneCards
DDX6
HPA
ENSG00000110367-DDX6
PRO
P26196
Pharos - Targets
P26196
GlyGen
P26196
Orphanet
DDX6
HMDB Protein
HMDBP11693
PDB
6F9S
,
5ANR
,
6S8S
,
2WAX
,
4CRW
,
4CT4
,
2WAY
,
1VEC
,
4CT5
Interactors (60)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NPI6 DCP1A
1
DCP1A [cytosol]
(R-HSA-430043)
0.925
13
UniProt:P67809 YBX1
5
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
p-S32,S36-YBX1 [cytosol]
(R-HSA-9736837)
YBX1 [cytosol]
(R-HSA-9736840)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.816
12
UniProt:Q9UKV8 AGO2
2
AGO2 [cytosol]
(R-HSA-209723)
AGO2 [nucleoplasm]
(R-HSA-5578701)
0.808
15
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.781
7
UniProt:Q96CA5 BIRC7
1
BIRC7 [cytosol]
(R-HSA-50855)
0.781
7
UniProt:P11940 PABPC1
1
PABPC1 [cytosol]
(R-HSA-156803)
0.763
5
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.723
10
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.718
6
UniProt:Q92841 DDX17
2
DDX17 [nucleoplasm]
(R-HSA-3900090)
monoSUMO1-K50-DDX17 [nucleoplasm]
(R-HSA-3900104)
0.666
4
UniProt:Q13123 IK
1
IK [nucleoplasm]
(R-HSA-9770239)
0.659
4
UniProt:P05388 RPLP0
1
RPLP0 [cytosol]
(R-HSA-72396)
0.623
3
UniProt:P62847 RPS24
2
RPS24 [cytosol]
(R-HSA-72355)
RPS24 [nucleoplasm]
(R-HSA-6791186)
0.615
3
UniProt:P62266 RPS23
3
RPS23 [cytosol]
(R-HSA-72353)
RPS23 [nucleoplasm]
(R-HSA-6791209)
3OHP62-RPS23 [nucleoplasm]
(R-HSA-9630773)
0.615
3
UniProt:P62263 RPS14
2
RPS14 [cytosol]
(R-HSA-72333)
RPS14 [nucleoplasm]
(R-HSA-6790669)
0.615
3
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.615
5
UniProt:P62280 RPS11
2
RPS11 [cytosol]
(R-HSA-72327)
RPS11 [nucleoplasm]
(R-HSA-6791212)
0.615
3
UniProt:P62917 RPL8
3
RPL8 [cytosol]
(R-HSA-72490)
RPL8 [nucleoplasm]
(R-HSA-9630985)
3OHH216-RPL8 [nucleoplasm]
(R-HSA-9630976)
0.615
3
UniProt:P62249 RPS16
2
RPS16 [cytosol]
(R-HSA-72337)
RPS16 [nucleoplasm]
(R-HSA-6791196)
0.615
4
UniProt:Q6PKG0 LARP1
1
LARP1 [cytosol]
(R-HSA-9760421)
0.615
3
UniProt:P15880 RPS2
3
RPS2 [cytosol]
(R-HSA-72347)
Me2aR-RPS2 [cytosol]
(R-HSA-8879138)
RPS2 [nucleoplasm]
(R-HSA-6790655)
0.615
3
UniProt:P62753 RPS6
4
RPS6 [cytosol]
(R-HSA-72381)
p-5S-RPS6 [cytosol]
(R-HSA-165727)
3OHR147-RPS6 [cytosol]
(R-HSA-9629876)
RPS6 [nucleoplasm]
(R-HSA-6790606)
0.615
3
UniProt:Q92900 UPF1
2
UPF1 [cytosol]
(R-HSA-927734)
p-4S-UPF1 [cytosol]
(R-HSA-927856)
0.595
3
UniProt:Q8NDV7 TNRC6A
2
TNRC6A [nucleoplasm]
(R-HSA-5578976)
TNRC6A [cytosol]
(R-HSA-427769)
0.569
4
UniProt:Q08211 DHX9
3
DHX9 [nucleoplasm]
(R-HSA-53517)
DHX9 [cytosol]
(R-HSA-847700)
p-DHX9 [cytosol]
(R-HSA-9836168)
0.564
4
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.564
3
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.556
3
UniProt:Q9BUH8 BEGAIN
1
BEGAIN [cytosol]
(R-HSA-6794250)
0.556
3
UniProt:Q15742 NAB2
1
NAB2 [nucleoplasm]
(R-HSA-9612177)
0.556
3
UniProt:Q9Y5V3 MAGED1
1
MAGED1 [cytosol]
(R-HSA-196002)
0.556
3
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-8S-N [cytosol]
(R-COV-9729335)
p-S188,206-N [cytosol]
(R-COV-9729324)
N [cytosol]
(R-COV-9694300)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
0.537
5
UniProt:P62318 SNRPD3
3
2xMe-SNRPD3 [cytosol]
(R-HSA-191781)
2xMe-SNRPD3 [nucleoplasm]
(R-HSA-192219)
SNRPD3 [nucleoplasm]
(R-HSA-71903)
0.536
3
UniProt:P07900 HSP90AA1
8
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
0.536
2
UniProt:Q12905 ILF2
5
ILF2 [cytosol]
(R-HSA-9836392)
ILF2 [ficolin-1-rich granule lumen]
(R-HSA-6801001)
ILF2 [extracellular region]
(R-HSA-6799684)
ILF2 [tertiary granule lumen]
(R-HSA-6800995)
ILF2 [specific granule lumen]
(R-HSA-6799611)
0.527
2
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.527
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P62241 RPS8
2
RPS8 [cytosol]
(R-HSA-72385)
RPS8 [nucleoplasm]
(R-HSA-6791203)
0.527
2
UniProt:Q12906 ILF3
3
ILF3 [nucleoplasm]
(R-HSA-9760401)
ILF3 [cytosol]
(R-HSA-450564)
p-T188,T315-ILF3 [cytosol]
(R-HSA-9836381)
0.527
3
UniProt:P62081 RPS7
2
RPS7 [cytosol]
(R-HSA-72383)
RPS7 [nucleoplasm]
(R-HSA-6790635)
0.527
2
UniProt:P46776 RPL27A
3
RPL27A [cytosol]
(R-HSA-72442)
RPL27A [nucleoplasm]
(R-HSA-9630984)
3OHH39-RPL27A [nucleoplasm]
(R-HSA-9630970)
0.527
2
UniProt:P05455 SSB
1
SSB [nucleoplasm]
(R-HSA-58418)
0.483
2
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.483
2
UniProt:P52272 HNRNPM
1
HNRNPM [nucleoplasm]
(R-HSA-71949)
0.483
2
UniProt:P06730 EIF4E
1
EIF4E [cytosol]
(R-HSA-72578)
0.483
2
UniProt:Q00839 HNRNPU
1
HNRNPU [nucleoplasm]
(R-HSA-71953)
0.483
2
UniProt:Q04637 EIF4G1
2
EIF4G1 [cytosol]
(R-HSA-72584)
p-S1108,S1148,S1192-EIF4G1 [cytosol]
(R-HSA-165762)
0.483
2
UniProt:Q9NZI8 IGF2BP1
1
IGF2BP1 [cytosol]
(R-HSA-428366)
0.483
2
UniProt:P61247 RPS3A
2
RPS3A [cytosol]
(R-HSA-72373)
RPS3A [nucleoplasm]
(R-HSA-6791182)
0.483
2
UniProt:P07910 HNRNPC
3
HNRNPC [nucleoplasm]
(R-HSA-71933)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [cytosol]
(R-HSA-9715136)
0.483
2
UniProt:P47756 CAPZB
1
CAPZB [cytosol]
(R-HSA-879409)
0.483
2
UniProt:Q9HD20 ATP13A1
1
ATP13A1 [endoplasmic reticulum membrane]
(R-HSA-939749)
0.483
2
UniProt:Q13627 DYRK1A
1
DYRK1A [nucleoplasm]
(R-HSA-1362267)
0.483
2
UniProt:P09651 HNRNPA1
2
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
HNRNPA1 [cytosol]
(R-HSA-9727902)
0.483
2
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.483
2
UniProt:P62244 RPS15A
2
RPS15A [cytosol]
(R-HSA-72345)
RPS15A [nucleoplasm]
(R-HSA-6791191)
0.483
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.483
2
UniProt:Q15717 ELAVL1
6
ELAVL1 [nucleoplasm]
(R-HSA-450601)
p-S158,S221-ELAVL1 [nucleoplasm]
(R-HSA-450576)
p-S221,S318-ELAVL1 [nucleoplasm]
(R-HSA-450532)
ELAVL1 [cytosol]
(R-HSA-450582)
p-S221,S318-ELAVL1 [cytosol]
(R-HSA-450448)
p-S158,S221-ELAVL1 [cytosol]
(R-HSA-450376)
0.483
2
UniProt:P46782 RPS5
2
RPS5 [cytosol]
(R-HSA-72379)
RPS5 [nucleoplasm]
(R-HSA-6791188)
0.483
2
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