mRNA decay by 5' to 3' exoribonuclease

Stable Identifier
R-HSA-430039
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Degradation of mRNA from 5' to 3' occurs in three steps. First, the mRNA is bound at its 3' end by the Lsm1-7 complex. The bound Lsm1-7 may prevent nucleases from accessing the 3' end. Second, the 7-methylguanosine cap of the mRNA is hydrolyzed by the DCP1-DCP2 complex. Third, the 5' end of the decapped mRNA is attacked by the XRN1 exoribonuclease which digests the remainder of the mRNA from 5' to 3'. These processes may be physically connected by PATL1, the homolog of yeast Pat1, which stably binds the Lsm1-7 complex and interacts with the DCP1-DCP2 decapping complex and the Ccr4-NOT deadenylation complex (Ozgur et al. 2010).

Literature References
PubMed ID Title Journal Year
16141059 From birth to death: the complex lives of eukaryotic mRNAs

Moore, MJ

Science 2005
14749774 The enzymes and control of eukaryotic mRNA turnover

Parker, R, Song, H

Nat Struct Mol Biol 2004
15475613 Messenger RNA decay in mammalian cells: the exonuclease perspective

Fritz, DT, Bergman, N, Kilpatrick, WJ, Wilusz, CJ, Wilusz, J

Cell Biochem Biophys 2004
20584987 Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies

Ozgur, S, Chekulaeva, M, Stoecklin, G

Mol Cell Biol 2010
19239894 The many pathways of RNA degradation

Houseley, J, Tollervey, D

Cell 2009
17245413 The highways and byways of mRNA decay

Garneau, NL, Wilusz, J, Wilusz, CJ

Nat Rev Mol Cell Biol 2007
11283721 The cap-to-tail guide to mRNA turnover

Wilusz, CJ, Wormington, M, Peltz, SW

Nat Rev Mol Cell Biol 2001
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Orthologous Events
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