Reactome | DCP1A [cytosol]

DCP1A [cytosol]

Stable Identifier

R-HSA-430043

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

mRNA-decapping enzyme 1A, DCP1A_HUMAN

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External Reference Information

External Reference

UniProt:Q9NPI6 DCP1A

Gene Names

DCP1A, SMIF

Chain

chain:1-582

Reference Genes

BioGPS Gene:55802 DCP1A

COSMIC (genes):DCP1A DCP1A

CTD Gene:55802 DCP1A

dbSNP Gene:55802 DCP1A

ENSEMBL:ENSG00000272886 DCP1A

ENSEMBL:ENSG00000272886.6 DCP1A

HGNC:18714 DCP1A

KEGG Gene (Homo sapiens):55802 DCP1A

Monarch:55802 DCP1A

NCBI Gene:55802 DCP1A

OMIM:607010 DCP1A

UCSC:Q9NPI6 DCP1A

Reference Transcript

Other Identifiers

11719470_a_at

11719471_at

16955096

16955098

218508_PM_at

218508_at

225443_PM_at

225443_at

2676718

2676719

2676720

2676721

2676722

2676723

2676725

2676727

2676728

2676731

2676732

2676733

2676736

2676738

2676747

2676749

2676751

2676759

2676760

2676761

2676762

2676763

44124_at

46655_at

47513_at

55802

8088126

8088128

A_23_P166826

A_24_P576174

GE55320

GE62764

GE87987

GO:0000184

GO:0000290

GO:0000932

GO:0003723

GO:0003729

GO:0003824

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0008047

GO:0008092

GO:0016020

GO:0016071

GO:0016787

GO:0019894

GO:0031087

GO:0036464

GO:0042802

GO:0043085

GO:0043226

GO:0043229

GO:0098772

GO:0110156

GO:0140933

GO:1903608

HMNXSV003050285

Hs.141003.0.S1_3p_at

ILMN_1809285

PH_hs_0008362

PH_hs_0024135

TC03001467.hg

TC03001468.hg

TC03002920.hg

g8923766_3p_at

p33547

Participates

as a component of

as an input of

Inferred To

DCP1 [cytosol] (Drosophila melanogaster)

DCP1 [cytosol] (Saccharomyces cerevisiae)

dcap-1 [cytosol] (Caenorhabditis elegans)

dcp1a [cytosol] (Xenopus tropicalis)

DCP1A [cytosol] (Bos taurus)

DCP1A [cytosol] (Canis familiaris)

DCP1A [cytosol] (Danio rerio)

DCP1A [cytosol] (Dictyostelium discoideum)

DCP1A [cytosol] (Gallus gallus)

DCP1A [cytosol] (Plasmodium falciparum)

DCP1A [cytosol] (Sus scrofa)

Dcp1a [cytosol] (Mus musculus)

Dcp1a [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001277133.1, NP_001277135.1, NP_060873.4, NP_001277134.1, NP_001277136.1

OpenTargets

ENSG00000272886

IntEnz

3.6.1.62

HPA

ENSG00000272886-DCP1A

GeneCards

Q9NPI6

Ensembl

ENSG00000272886, ENST00000610213, ENST00000294241, ENSP00000476386, ENSP00000476046

PRO

Q9NPI6

Pharos - Targets

Q9NPI6

PDB

4B6H, 2WX3

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IU60 DCP2	1	DCP2 [cytosol] (R-HSA-429937)	0.937	16
UniProt:Q96F86 EDC3	1	EDC3 [cytosol] (R-HSA-429997)	0.937	14
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.88	9
UniProt:Q9NPJ4 PNRC2	1	PNRC2 [cytosol] (R-HSA-8879146)	0.878	11
UniProt:Q6P2E9 EDC4	1	EDC4 [cytosol] (R-HSA-429963)	0.842	11
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.783	13
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.781	10
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.779	5
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.761	9
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.728	5
UniProt:Q8IZD4 DCP1B	1	DCP1B [cytosol] (R-HSA-429834)	0.695	8
UniProt:Q9NPJ4-1 PNRC2			0.671	6
UniProt:Q96K30 RITA1			0.666	4
UniProt:Q86TB9 PATL1	1	PATL1 [cytosol] (R-HSA-2028617)	0.564	2
UniProt:Q3E7X9 RPS28A	3	RPS28A [nucleoplasm] (R-SCE-6791202-2) RPS28A [cytosol] (R-SCE-9633107) RPS28A [cytosol] (R-SCE-72365-2)	0.556	3
UniProt:P43351 RAD52	3	monoSUMO1-K411,K412,K414-RAD52 [nucleoplasm] (R-HSA-4568909) RAD52 [nucleoplasm] (R-HSA-62639) p-Y104-RAD52 [nucleoplasm] (R-HSA-5686588)	0.556	5
UniProt:Q8IU60-2 DCP2			0.527	2
UniProt:F4HZB2 BCHA1			0.527	2
UniProt:Q12796 PNRC1			0.527	2
UniProt:Q92636 NSMAF	1	NSMAF [cytosol] (R-HSA-5626992)	0.527	2
UniProt:A0A0U1RRE5 NBDY			0.499	4
UniProt:P26651 ZFP36	2	p-S60,S186-ZFP36 [cytosol] (R-HSA-450496) ZFP36 [cytosol] (R-HSA-450562)	0.499	2

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