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DCP1A [cytosol]
Stable Identifier
R-HSA-430043
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
mRNA-decapping enzyme 1A, DCP1A_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Deadenylation-dependent mRNA decay (Homo sapiens)
mRNA decay by 5' to 3' exoribonuclease (Homo sapiens)
DCP1-DCP2 complex decaps mRNA (Homo sapiens)
DCP1-DCP2 Decapping Complex [cytosol] (Homo sapiens)
DCP1A [cytosol] (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
DCP1A [cytosol] (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Homo sapiens)
BRF1 Complex recruits RNA degradation activities (Homo sapiens)
BRF1:mRNA Degradation Complex [cytosol] (Homo sapiens)
DCP1A [cytosol] (Homo sapiens)
DCP1A [cytosol] (Homo sapiens)
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA (Homo sapiens)
ZFP36 (TTP) recruits RNA degradation activities (Homo sapiens)
DCP1A [cytosol] (Homo sapiens)
TTP:mRNA Degradation Complex [cytosol] (Homo sapiens)
DCP1A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NPI6 DCP1A
Gene Names
DCP1A, SMIF
Chain
chain:1-582
Reference Genes
BioGPS Gene:55802 DCP1A
COSMIC (genes):DCP1A DCP1A
CTD Gene:55802 DCP1A
dbSNP Gene:55802 DCP1A
ENSEMBL:ENSG00000272886 DCP1A
HGNC:18714 DCP1A
KEGG Gene (Homo sapiens):55802 DCP1A
Monarch:55802 DCP1A
NCBI Gene:55802 DCP1A
OMIM:607010 DCP1A
UCSC:Q9NPI6 DCP1A
Reference Transcript
RefSeq:NM_001290206.1 DCP1A
RefSeq:NM_001290204.1 DCP1A
RefSeq:NM_018403.6 DCP1A
RefSeq:NM_001290205.1 DCP1A
RefSeq:NM_001290207.1 DCP1A
Other Identifiers
0006660358
11719470_a_at
11719471_at
16955096
16955098
218508_at
225443_at
2676718
2676719
2676720
2676721
2676722
2676723
2676725
2676727
2676728
2676731
2676732
2676733
2676736
2676738
2676747
2676749
2676751
2676759
2676760
2676761
2676762
2676763
44124_at
46655_at
47513_at
55802
8088126
8088128
A_23_P166826
A_24_P576174
GE55320
GE62764
GE87987
GO:0000184
GO:0000290
GO:0000932
GO:0003674
GO:0003723
GO:0003729
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0008047
GO:0008092
GO:0008150
GO:0009056
GO:0016020
GO:0016787
GO:0019894
GO:0030234
GO:0031087
GO:0034641
GO:0034655
GO:0036464
GO:0042802
GO:0043085
GO:0043226
GO:0043488
GO:0043928
GO:1903608
Hs.141003.0.S1_3p_at
ILMN_1809285
PH_hs_0008362
PH_hs_0024135
TC03001467.hg
TC03001468.hg
TC03002920.hg
g8923766_3p_at
Participant Of
hasComponent
BRF1:mRNA Degradation Complex [cytosol]
DCP1-DCP2 Decapping Complex [cytosol]
TTP:mRNA Degradation Complex [cytosol]
input
BRF1 Complex recruits RNA degradation activities
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A
ZFP36 (TTP) recruits RNA degradation activities
Inferred To
DCP1 [cytosol] (Drosophila melanogaster)
DCP1 [cytosol] (Saccharomyces cerevisiae)
dcap-1 [cytosol] (Caenorhabditis elegans)
dcp1a [cytosol] (Danio rerio)
dcp1a [cytosol] (Xenopus tropicalis)
DCP1A [cytosol] (Canis familiaris)
DCP1A [cytosol] (Dictyostelium discoideum)
DCP1A [cytosol] (Gallus gallus)
DCP1A [cytosol] (Plasmodium falciparum)
DCP1A [cytosol] (Sus scrofa)
Dcp1a [cytosol] (Mus musculus)
Dcp1a [cytosol] (Rattus norvegicus)
Cross References
RefSeq
NP_001277135.1
,
NP_001277133.1
,
NP_001277134.1
,
NP_001277136.1
,
NP_060873.4
OpenTargets
ENSG00000272886
GeneCards
Q9NPI6
HPA
ENSG00000272886-DCP1A
Ensembl
ENSG00000272886
,
ENSP00000476046
,
ENSP00000476386
,
ENST00000294241
,
ENST00000610213
PRO
Q9NPI6
PDB
2WX3
,
4B6H
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96F86 EDC3
1
EDC3 [cytosol]
(R-HSA-429997)
0.937
14
UniProt:Q8IU60 DCP2
1
DCP2 [cytosol]
(R-HSA-429937)
0.908
10
UniProt:P26196 DDX6
1
DDX6 [cytosol]
(R-HSA-430032)
0.88
9
UniProt:Q9NPJ4 PNRC2
1
PNRC2 [cytosol]
(R-HSA-8879146)
0.837
10
UniProt:Q6P2E9 EDC4
1
EDC4 [cytosol]
(R-HSA-429963)
0.787
10
UniProt:Q92900 UPF1
2
p-4S-UPF1 [cytosol]
(R-HSA-927856)
UPF1 [cytosol]
(R-HSA-927734)
0.783
13
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.781
10
UniProt:Q13485 SMAD4
88
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 G352* [cytosol]
(R-HSA-9678445)
SMAD4 S178* [cytosol]
(R-HSA-9675630)
SMAD4 G477* [cytosol]
(R-HSA-9678447)
SMAD4 G473* [cytosol]
(R-HSA-9678440)
SMAD4 S144* [cytosol]
(R-HSA-9675625)
SMAD4 E538* [cytosol]
(R-HSA-9675626)
SMAD4 E390* [cytosol]
(R-HSA-9675620)
SMAD4 S154* [cytosol]
(R-HSA-9675621)
SMAD4 E330* [cytosol]
(R-HSA-9675622)
SMAD4 E417* [cytosol]
(R-HSA-9675623)
SMAD4 Y195* [cytosol]
(R-HSA-9678462)
SMAD4 E108* [cytosol]
(R-HSA-9675640)
SMAD4 S343* [cytosol]
(R-HSA-9675641)
SMAD4 E520* [cytosol]
(R-HSA-9675636)
SMAD4 G510* [cytosol]
(R-HSA-9678452)
SMAD4 G358* [cytosol]
(R-HSA-9678453)
SMAD4 E175* [cytosol]
(R-HSA-9675637)
SMAD4 E307* [cytosol]
(R-HSA-9675639)
SMAD4 E53* [cytosol]
(R-HSA-9675633)
SMAD4 S171* [cytosol]
(R-HSA-9675634)
SMAD4 G30* [cytosol]
(R-HSA-9678450)
SMAD4 G168* [cytosol]
(R-HSA-9678451)
SMAD4 Q366* [cytosol]
(R-HSA-9675200)
SMAD4 R135* [cytosol]
(R-HSA-9675090)
SMAD4 L146* [cytosol]
(R-HSA-9678509)
SMAD4 L440* [cytosol]
(R-HSA-9678510)
SMAD4 Q183* [cytosol]
(R-HSA-9675176)
SMAD4 Q289* [cytosol]
(R-HSA-9675177)
SMAD4 Q248* [cytosol]
(R-HSA-9675178)
SMAD4 Q249* [cytosol]
(R-HSA-9675172)
SMAD4 Q256* [cytosol]
(R-HSA-9675173)
SMAD4 Q239* [cytosol]
(R-HSA-9675174)
SMAD4 Q245* [cytosol]
(R-HSA-9675175)
SMAD4 Q224* [cytosol]
(R-HSA-9675168)
SMAD4 W509* [cytosol]
(R-HSA-9678497)
SMAD4 Q311* [cytosol]
(R-HSA-9675169)
SMAD4 W398* [cytosol]
(R-HSA-9678498)
SMAD4 Q250* [cytosol]
(R-HSA-9675170)
SMAD4 Q410* [cytosol]
(R-HSA-9675196)
SMAD4 Q534* [cytosol]
(R-HSA-9675197)
SMAD4 Q83* [cytosol]
(R-HSA-9675199)
SMAD4 Q448* [cytosol]
(R-HSA-9675192)
SMAD4 K428R [cytosol]
(R-HSA-3311001)
SMAD4 Q455* [cytosol]
(R-HSA-9675193)
SMAD4 R445* [cytosol]
(R-HSA-9675065)
SMAD4 Q442* [cytosol]
(R-HSA-9675194)
SMAD4 Q516* [cytosol]
(R-HSA-9675195)
SMAD4 C443* [cytosol]
(R-HSA-9678523)
SMAD4 Q334* [cytosol]
(R-HSA-9675191)
SMAD4 R361G [cytosol]
(R-HSA-3310993)
SMAD4 L172* [cytosol]
(R-HSA-9678514)
SMAD4 K122* [cytosol]
(R-HSA-9678515)
SMAD4 R361S [cytosol]
(R-HSA-3310994)
SMAD4 Y430* [cytosol]
(R-HSA-9678476)
SMAD4 Y260* [cytosol]
(R-HSA-9678477)
SMAD4 Y95* [cytosol]
(R-HSA-9678478)
SMAD4 Y322* [cytosol]
(R-HSA-9678479)
SMAD4 E321* [cytosol]
(R-HSA-9675658)
SMAD4 Y412* [cytosol]
(R-HSA-9678469)
SMAD4 R515* [cytosol]
(R-HSA-3311012)
SMAD4 Y328* [cytosol]
(R-HSA-9678470)
SMAD4 E33* [cytosol]
(R-HSA-9675654)
SMAD4 Y513* [cytosol]
(R-HSA-9678471)
SMAD4 E526* [cytosol]
(R-HSA-9675648)
SMAD4 S138* [cytosol]
(R-HSA-9675649)
SMAD4 Y276* [cytosol]
(R-HSA-9678466)
SMAD4 E205* [cytosol]
(R-HSA-9675650)
SMAD4 E49* [cytosol]
(R-HSA-9675651)
SMAD4 W101* [cytosol]
(R-HSA-9678492)
SMAD4 W268* [cytosol]
(R-HSA-9678494)
SMAD4 [nucleoplasm]
(R-HSA-177103)
SMAD4 [cytosol]
(R-HSA-170862)
RibC-SMAD4 [nucleoplasm]
(R-HSA-2187323)
SMAD4 W524* [cytosol]
(R-HSA-9678491)
SMAD4 W302* [cytosol]
(R-HSA-9678490)
SMAD4 S242* [cytosol]
(R-HSA-9675167)
SMAD4 Q116* [cytosol]
(R-HSA-9675166)
0.779
5
UniProt:Q9NPI6 DCP1A
1
DCP1A [cytosol]
(R-HSA-430043)
0.761
9
UniProt:O95429 BAG4
3
BAG4(1-126):p-8Y FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853156)
BAG4 [cytosol]
(R-HSA-5212670)
BAG4(1-126):FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853157)
0.728
5
UniProt:Q8IZD4 DCP1B
1
DCP1B [cytosol]
(R-HSA-429834)
0.695
8
UniProt:Q9NPJ4-1 PNRC2
0.671
6
UniProt:Q96K30 RITA1
0.666
4
UniProt:Q3E7X9 RPS28A
1
RPS28A [cytosol]
(R-SCE-9633107)
0.556
3
UniProt:P43351 RAD52
3
RAD52 [nucleoplasm]
(R-HSA-62639)
SUMO1-K411,K412,K414-RAD52 [nucleoplasm]
(R-HSA-4568909)
p-Y104-RAD52 [nucleoplasm]
(R-HSA-5686588)
0.556
5
UniProt:Q8IU60-2 DCP2
0.527
2
UniProt:F4HZB2 BCHA1
0.527
2
UniProt:Q12796 PNRC1
0.527
2
UniProt:Q92636 NSMAF
1
NSMAF [cytosol]
(R-HSA-5626992)
0.527
2
UniProt:P26651 ZFP36
2
ZFP36 [cytosol]
(R-HSA-450562)
p-S60,S186-ZFP36 [cytosol]
(R-HSA-450496)
0.499
2
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