GP1b-IX-V binds 14-3-3-zeta

Stable Identifier
R-HSA-430076
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The Gp1b-IX-V complex binds to 14-3-3-zeta, a scaffolding protein. The highly conserved cytoplasmic domain of GpIb alpha binds directly to dimeric 14-3-3 zeta adapter protein. Binding also involves regions of GpV, and is enhanced by phosphorylation of GP1b at Ser-609 or Ser-166 of Gp1b alpha and beta respectively. For Gp1b beta this phosphorylation is PKA-dependent.

Literature References
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Orthologous Events
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Created