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VAV1,2,3 [cytosol]
Stable Identifier
R-HSA-430172
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Synonyms
VAV1,VAV2,VAV3
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK (Homo sapiens)
IgG:Leishmania surface:FCGR3Ap-CD3 dimers:p-6Y-SYK:VAV1,2,3:PI(3,4,5)P3 [plasma membrane] (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
p-6Y-SYK phosphorylates VAV1,2,3 (Homo sapiens)
IgG:Leishmania surface:FCGR3Ap-CD3 dimers:p-6Y-SYK:VAV1,2,3:PI(3,4,5)P3 [plasma membrane] (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 is a GEF for Rho/Rac family GTPases (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
p-SLP-76 binds VAV (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
p-SLP-76:VAV [cytosol] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Autophosphorylation of BTK/ITK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
Hydrolysis of PIP2 by PLCG (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
Phosphorylation of PLC-gamma (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
Phosphorylation of TEC kinases by p-SYK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
Recruitment of TEC kinases to p-SLP-76 (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Phosphorylation and activation of VAV (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
Recruitment of VAV to p-SLP-76 (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Phosphorylation of VAV (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
Recruitment of VAV1 to p-6Y-SYK (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
Src kinases phosphorylate VAV (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
Participants
members
VAV1 [cytosol]
(Homo sapiens)
VAV2 [cytosol]
(Homo sapiens)
VAV3 [cytosol]
(Homo sapiens)
Participates
as a component of
p-SLP-76:VAV [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
as an input of
p-SLP-76 binds VAV (Homo sapiens)
Recruitment of VAV1 to p-6Y-SYK (Homo sapiens)
PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)
Recruitment of VAV to p-SLP-76 (Homo sapiens)
Inferred To
VAV1,2,3 [cytosol]
(Bos taurus)
VAV1,2,3 [cytosol]
(Canis familiaris)
VAV1,2,3 [cytosol]
(Gallus gallus)
VAV1,2,3 [cytosol]
(Mus musculus)
VAV1,2,3 [cytosol]
(Rattus norvegicus)
VAV1,2,3 [cytosol]
(Sus scrofa)
VAV1,2,3 [cytosol]
(Xenopus tropicalis)
vav-1 [cytosol]
(Caenorhabditis elegans)
Vav [cytosol]
(Drosophila melanogaster)
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