NCK binds PAK

Stable Identifier
R-HSA-430183
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NCK binds to PAK through its second SH3 domain. PAK interacts with NCK via the amino terminal SH3 binding domain. This interaction leads to the phosphorylation of NCK at multiple sites.

Literature References
PubMed ID Title Journal Year
8824201 Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

Bokoch, GM, Wang, Y, Bohl, BP, Sells, MA, Quilliam, LA, Knaus, UG

J Biol Chem 1996
8798379 The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

Galisteo, ML, Chernoff, J, Su, YC, Skolnik, EY, Schlessinger, J

J Biol Chem 1996
Participants
Participant Of
Orthologous Events
Authored
Reviewed