Reactome | MIP [plasma membrane]

MIP [plasma membrane]

Stable Identifier

R-HSA-432026

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Lens fiber major intrinsic protein, MIP_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P30301 MIP

Gene Names

MIP, AQP0

Chain

chain:1-263

Reference Genes

BioGPS Gene:4284 MIP

COSMIC (genes):MIP MIP

CTD Gene:4284 MIP

dbSNP Gene:4284 MIP

ENSEMBL:ENSG00000135517 MIP

ENSEMBL_homo_sapiens_GENE:ENSG00000135517.9 MIP

HGNC:7103 MIP

KEGG Gene (Homo sapiens):4284 MIP

Monarch:4284 MIP

NCBI Gene:4284 MIP

OMIM:154050 MIP

UCSC:P30301 MIP

Reference Transcript

RefSeq:NM_012064.3 MIP

Other Identifiers

11740316_a_at

11740317_at

16766175

220863_PM_at

220863_at

3457870

3457871

3457873

3457874

3457875

3457876

3457877

3457878

3457879

3457880

3457881

4284

7964177

A_23_P47806

GE80650

GO:0002088

GO:0005198

GO:0005212

GO:0005215

GO:0005515

GO:0005516

GO:0005783

GO:0005886

GO:0005921

GO:0006833

GO:0007155

GO:0007601

GO:0015250

GO:0015267

GO:0016020

GO:0016324

GO:0043226

GO:0045785

GO:0048856

GO:0050877

GO:0050896

GO:0051289

GO:0055085

GO:0065003

GO:0070161

GO:1990349

HMNXSV003012667

ILMN_1676490

PH_hs_0019301

PH_hs_0034847

TC12001606.hg

g6912505_3p_at

Participates

as a component of

Lens fiber major intrinsic protein (AQP0) tetramer [plasma membrane] (Homo sapiens)

Inferred To

Drip [plasma membrane] (Drosophila melanogaster)

mip1 [plasma membrane] (Danio rerio)

Eglp2 [plasma membrane] (Drosophila melanogaster)

Mip [plasma membrane] (Mus musculus)

Mip [plasma membrane] (Rattus norvegicus)

aqpA [plasma membrane] (Dictyostelium discoideum)

wacA [plasma membrane] (Dictyostelium discoideum)

MIP [plasma membrane] (Bos taurus)

MIP [plasma membrane] (Canis familiaris)

MIP [plasma membrane] (Dictyostelium discoideum)

MIP [plasma membrane] (Gallus gallus)

MIP [plasma membrane] (Plasmodium falciparum)

MIP [plasma membrane] (Sus scrofa)

Homologues of MIP [plasma membrane] (Danio rerio)

Homologues of MIP [plasma membrane] (Dictyostelium discoideum)

Homologues of MIP [plasma membrane] (Drosophila melanogaster)

Prip [plasma membrane] (Drosophila melanogaster)

mip2 [plasma membrane] (Danio rerio)

bib [plasma membrane] (Drosophila melanogaster)

Eglp3 [plasma membrane] (Drosophila melanogaster)

Eglp4 [plasma membrane] (Drosophila melanogaster)

Eglp1 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_036196.1

Guide to Pharmacology - Targets

687

OpenTargets

ENSG00000135517

GeneCards

P30301

HPA

ENSG00000135517-MIP

Ensembl

ENSG00000135517, ENSP00000498622, ENST00000652304

PRO

P30301

Pharos - Targets

P30301

Orphanet

16401

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95470 SGPL1	1	PXLP-SGPL1 [endoplasmic reticulum membrane] (R-HSA-428661)	0.556	3
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.556	3
UniProt:P54652 HSPA2	2	HSPA2 [cytosol] (R-HSA-3371408) HSPA2 [nucleoplasm] (R-HSA-912480)	0.556	3
UniProt:P21579 SYT1	7	SYT1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869113) SYT1 [synaptic vesicle membrane] (R-HSA-194789) SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane] (R-HSA-210536) SYT1 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-372514) SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917741) SYT1 [plasma membrane] (R-HSA-168786) SYT1 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372508)	0.556	3
UniProt:O00501 CLDN5	2	CLDN5 [cell junction] (R-HSA-421264) CLDN5 [plasma membrane] (R-HSA-419991)	0.556	3
UniProt:Q99437 ATP6V0B	3	ATP6V0B [endosome membrane] (R-HSA-912584) ATP6V0B [phagocytic vesicle membrane] (R-HSA-1222695) ATP6V0B [lysosomal membrane] (R-HSA-9640187)	0.556	3
UniProt:Q9HC36 MRM3	1	RNMTL1 [mitochondrial matrix] (R-HSA-6793067)	0.556	3

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