Reactome | Transport of glycerol from adipocytes to the liver by Aquaporins

Transport of glycerol from adipocytes to the liver by Aquaporins

Stable Identifier

R-HSA-432030

Type

Pathway

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Transport of glycerol from adipocytes to the liver by Aquaporins

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Triglycerides stored in adipocytes are hydrolyzed to yield fatty acids and glycerol. The glycerol is passively transported out of the adipocyte and into the bloodstream by Aquaporin-7 (AQP7) located in the plasma membrane of adipocytes. Glycerol in the bloodstream is passively transported into liver cells by AQP9 located in the plasma membrane of hepatocytes. Once inside the liver cell the glycerol is a substrate for gluconeogenesis.

Literature References

PubMed ID	Title	Journal	Year
19096781	Role of aquaporin-7 and aquaporin-9 in glycerol metabolism; involvement in obesity Maeda, N, Hibuse, T, Funahashi, T	Handb Exp Pharmacol	2009
16764946	Aquaporin-7 and glycerol permeability as novel obesity drug-target pathways Frühbeck, G, Catalán, V, Gómez-Ambrosi, J, Rodriguez, A	Trends Pharmacol Sci	2006