Aquaporin-6 passively transports anions into vesicles

Stable Identifier
R-HSA-432034
Type
Reaction [transition]
Species
Homo sapiens
Compartment
transport vesicle membrane, cytosol, transport vesicle
ReviewStatus
5/5
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Aquaporin-6 passively transports anions into vesicles
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Aquaporin-6 (AQP6) passively transports anions across membranes. Rat AQP6 has been shown to transport anions, with the highest permeability for nitrate, the lowest permeability for fluoride, and low permeability for water. In rat AQP6 is expressed in the acid-secreting type-A intercalated cells of renal ducts where it co-localizes with the proton-ATPase in the membranes of intracellular vesicles. AQP6 is gated by low pH.
Literature References
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Output
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as an event of
Event Information
Reverse Reaction
Aquaporin-6 passively transports anions out of vesicles (Homo sapiens)
Catalyst Activity

monoatomic anion channel activity of AQP6 tetramer [transport vesicle membrane]

Physical Entity
AQP6 tetramer [transport vesicle membrane] (Homo sapiens)
Activity
monoatomic anion channel activity (GO:0005253)
Inferred From
Passive Transport of Anions into Vesicles by Aquaporin-6 (rat) (Rattus norvegicus)
Cross References
RHEA
Authored
May, B  (2009-08-07)
Reviewed
Beitz, E  (2010-06-24)
Calamita, G  (2010-07-15)
Mathai, JC  (2010-07-31)
MacIver, B  (2010-07-31)
Created
May, B  (2009-08-09)
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