Reactome | Aquaporin-9 passively transports glycerol into cell

Aquaporin-9 passively transports glycerol into cell

Stable Identifier

R-HSA-432049

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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Aquaporin-9 passively transports glycerol into cell

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Aquaporin-9 (AQP9) passively transports water, glycerol, urea, and some other small neutral solutes across the plasma membrane according to the osmotic gradient. AQP9 is expressed in the sinusoidal plasma membrane in the liver facing the portal vein where it is believed to be responsible for glycerol uptake as part of gluconeogenesis. AQP9 is also expressed in glia, neurons, and peripheral leukocytes.

Literature References

PubMed ID	Title	Journal	Year
18762715	Functional characterization of human aquaporin 9 as a facilitative glycerol carrier Ohgusu, Y, Ohta, KY, Ishii, M, Katano, T, Urano, K, Watanabe, J, Inoue, K, Yuasa, H	Drug Metab Pharmacokinet	2008
19590626	Altered aquaporin 9 expression and localization in human hepatocellular carcinoma Padma, S, Smeltz, AM, Banks, PM, Iannitti, DA, McKillop, IH	HPB (Oxford)	2009
11027599	Immunolocalization of AQP9 in liver, epididymis, testis, spleen, and brain Elkjaer, M, Vajda, Z, Nejsum, LN, Kwon, T, Jensen, UB, Amiry-Moghaddam, M, Frøkiaer, J, Nielsen, S	Biochem Biophys Res Commun	2000
10564231	Functional and molecular characterization of the human neutral solute channel aquaporin-9 Tsukaguchi, H, Weremowicz, S, Morton, CC, Hediger, MA	Am J Physiol	1999
17961083	A current view of the mammalian aquaglyceroporins Rojek, A, Praetorius, J, Frøkiaer, J, Nielsen, S, Fenton, RA	Annu Rev Physiol	2008