Activated integrin alphaIIb beta3 binds SHC1

Stable Identifier
R-HSA-432096
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The beta 3 integrin cytoplasmic tail binds SH2-containing protein (SHC), an adapter in Ras signaling. Phosphorylation of Y785 may be necessary for binding; phosphorylation of T779 inhibits SHC binding. Mice expressing a mutated beta 3 where Y773 and Y785 have been mutated to F exhibit rebleeding from tail wounds and subtle defects in clot retraction and platelet aggregation.
Literature References
PubMed ID Title Journal Year
8631894 Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation

Nannizzi-Alaimo, L, Phillips, DR, Law, DA

J Biol Chem 1996
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