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Activated integrin alphaIIb beta3 binds SHC1
Stable Identifier
R-HSA-432096
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)
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The beta 3 integrin cytoplasmic tail binds SH2-containing protein (SHC), an adapter in Ras signaling. Phosphorylation of Y785 may be necessary for binding; phosphorylation of T779 inhibits SHC binding. Mice expressing a mutated beta 3 where Y773 and Y785 have been mutated to F exhibit rebleeding from tail wounds and subtle defects in clot retraction and platelet aggregation.
Literature References
PubMed ID
Title
Journal
Year
8631894
Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation
Nannizzi-Alaimo, L
,
Phillips, DR
,
Law, DA
J Biol Chem
1996
Participants
Input
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane]
(Homo sapiens)
SHC1 [cytosol]
(Homo sapiens)
Output
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane]
(Homo sapiens)
Participates
as an event of
Integrin signaling (Homo sapiens)
Orthologous Events
Activated integrin alphaIIb beta3 binds SHC1 (Bos taurus)
Activated integrin alphaIIb beta3 binds SHC1 (Canis familiaris)
Activated integrin alphaIIb beta3 binds SHC1 (Drosophila melanogaster)
Activated integrin alphaIIb beta3 binds SHC1 (Gallus gallus)
Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)
Activated integrin alphaIIb beta3 binds SHC1 (Rattus norvegicus)
Activated integrin alphaIIb beta3 binds SHC1 (Sus scrofa)
Authored
Akkerman, JW (2009-09-04)
Reviewed
Heemskerk, JW (2010-09-01)
Created
Jupe, S (2009-08-10)
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