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LRP8 [plasma membrane]
Stable Identifier
R-HSA-432113
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
ApoER2, Low-density lipoprotein receptor-related protein 8, Apolipoprotein E receptor 2, LRP8_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet sensitization by LDL (Homo sapiens)
FGR binds LDL:LRP8 (Homo sapiens)
LDL:LRP8 [plasma membrane] (Homo sapiens)
LRP8 [plasma membrane] (Homo sapiens)
LDL:LRP8:FGR [plasma membrane] (Homo sapiens)
LDL:LRP8 [plasma membrane] (Homo sapiens)
LRP8 [plasma membrane] (Homo sapiens)
FGR binds and phosphorylates LRP8 (Homo sapiens)
LDL:LRP8:FGR [plasma membrane] (Homo sapiens)
LDL:LRP8 [plasma membrane] (Homo sapiens)
LRP8 [plasma membrane] (Homo sapiens)
LDL binds to LRP8 (Homo sapiens)
LDL:LRP8 [plasma membrane] (Homo sapiens)
LRP8 [plasma membrane] (Homo sapiens)
LRP8 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
LRPs [plasma membrane] (Homo sapiens)
LRP8 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
LRPs [plasma membrane] (Homo sapiens)
LRP8 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14114 LRP8
Gene Names
LRP8, APOER2
Chain
signal peptide:1-32, chain:33-963
Reference Genes
BioGPS Gene:7804 LRP8
COSMIC (genes):LRP8 LRP8
CTD Gene:7804 LRP8
dbSNP Gene:7804 LRP8
ENSEMBL:ENSG00000157193 LRP8
HGNC:6700 LRP8
KEGG Gene (Homo sapiens):7804 LRP8
Monarch:7804 LRP8
NCBI Gene:7804 LRP8
OMIM:602600 LRP8
UCSC:Q14114 LRP8
Reference Transcript
RefSeq:NM_033300.3 LRP8
RefSeq:NM_001018054.2 LRP8
RefSeq:NM_004631.4 LRP8
RefSeq:NM_017522.4 LRP8
Other Identifiers
0003780059
0005690020
11724797_a_at
11724798_x_at
11728896_a_at
11741376_a_at
11747761_a_at
11747762_x_at
16687352
205282_at
208433_s_at
210092_at
228955_at
2413197
2413198
2413202
2413204
2413205
2413206
2413207
2413208
2413209
2413210
2413211
2413212
2413213
2413214
2413218
2413219
2413220
2413221
2413224
2413225
2413226
2413228
2413229
2413231
2413232
2413241
2413242
2413246
2413253
2413277
2413282
2413283
2413284
32398_s_at
40012_at
58519_at
58521_g_at
7804
7916282
A_23_P34325
A_32_P98979
D50678_at
GE62717
GO:0000902
GO:0001523
GO:0002376
GO:0003674
GO:0004888
GO:0005041
GO:0005509
GO:0005515
GO:0005575
GO:0005576
GO:0005622
GO:0005856
GO:0005875
GO:0005886
GO:0005901
GO:0006464
GO:0006508
GO:0006629
GO:0006810
GO:0006897
GO:0006950
GO:0007165
GO:0007267
GO:0008035
GO:0008092
GO:0008150
GO:0008219
GO:0009058
GO:0014069
GO:0016020
GO:0016021
GO:0016192
GO:0019221
GO:0019894
GO:0021541
GO:0021987
GO:0030154
GO:0030229
GO:0030424
GO:0030425
GO:0032793
GO:0032991
GO:0034185
GO:0034330
GO:0034641
GO:0038024
GO:0038025
GO:0038026
GO:0042493
GO:0042981
GO:0043025
GO:0043167
GO:0043226
GO:0043235
GO:0045088
GO:0048856
GO:0050731
GO:0050804
GO:0061003
GO:0061098
GO:0071363
GO:0071397
GO:1900006
Hs.27379.0.A1_3p_at
Hs.27379.0.A1_3p_x_at
ILMN_1677765
ILMN_2302654
PH_hs_0024845
PH_hs_0025145
TC01002669.hg
Z75190_s_at
g4758687_3p_at
g8923799_3p_a_at
Participant Of
hasMember
LRPs [plasma membrane]
input
LDL binds to LRP8
hasComponent
LDL:LRP8 [plasma membrane]
Other forms of this molecule
p-Y-LRP8 [plasma membrane]
Inferred To
Lrp8 [plasma membrane] (Mus musculus)
Lrp8 [plasma membrane] (Rattus norvegicus)
LRP8 [plasma membrane] (Canis familiaris)
LRP8 [plasma membrane] (Sus scrofa)
fbxw7 [plasma membrane] (Xenopus tropicalis)
lrp8 [plasma membrane] (Danio rerio)
Cross References
RefSeq
NP_004622.2
,
NP_150643.2
,
NP_001018064.1
,
NP_059992.3
OpenTargets
ENSG00000157193
GeneCards
Q14114
HPA
ENSG00000157193-LRP8
Ensembl
ENSP00000303634
,
ENSG00000157193
,
ENST00000371454
,
ENST00000347547
,
ENST00000306052
,
ENSP00000360509
,
ENSP00000334522
,
ENSP00000346391
,
ENST00000354412
PRO
Q14114
PDB
5B4X
,
3A7Q
,
5B4Y
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q60841
1
Reln [extracellular region]
(R-MMU-8854469)
0.769
10
UniProt:P25054 APC
86
APC C1410* [cytosol]
(R-HSA-9666925)
APC R213* [cytosol]
(R-HSA-9666924)
APC K1310* [cytosol]
(R-HSA-9666926)
APC R499* [cytosol]
(R-HSA-9666927)
APC R1450* [cytosol]
(R-HSA-5251499)
APC G1357* [cytosol]
(R-HSA-9666940)
APC L1488* [cytosol]
(R-HSA-9666941)
APC S1400* [cytosol]
(R-HSA-9666942)
APC S1346* [cytosol]
(R-HSA-9666943)
APC R405* [cytosol]
(R-HSA-9666936)
APC S1281* [cytosol]
(R-HSA-9666937)
APC E1573* [cytosol]
(R-HSA-9666938)
APC R805* [cytosol]
(R-HSA-9666939)
APC R1386* [cytosol]
(R-HSA-9666932)
APC S1327* [cytosol]
(R-HSA-9666933)
APC E1209* [cytosol]
(R-HSA-9666934)
APC Q1469* [cytosol]
(R-HSA-9666935)
APC R564* [cytosol]
(R-HSA-9666928)
APC E1536* [cytosol]
(R-HSA-9666929)
APC G1288* [cytosol]
(R-HSA-9666930)
APC G1312* [cytosol]
(R-HSA-9666931)
APC R283* [cytosol]
(R-HSA-9666988)
APC Q1367* [cytosol]
(R-HSA-9666989)
APC E1353* [cytosol]
(R-HSA-9666990)
APC R332* [cytosol]
(R-HSA-9666991)
APC K993* [cytosol]
(R-HSA-9666984)
APC R876* [cytosol]
(R-HSA-9666985)
APC R302* [cytosol]
(R-HSA-9666986)
APC E1309* [cytosol]
(R-HSA-9666987)
APC Y935* [cytosol]
(R-HSA-9666980)
APC E1286* [cytosol]
(R-HSA-9666981)
APC Q1378* [cytosol]
(R-HSA-9666982)
APC R554* [cytosol]
(R-HSA-9666983)
APC S1356* [cytosol]
(R-HSA-9666976)
APC R232* [cytosol]
(R-HSA-9666977)
APC E1379* [cytosol]
(R-HSA-9666978)
APC E984* [cytosol]
(R-HSA-9666979)
APC R1114* [cytosol]
(R-HSA-9666996)
APC S1282* [cytosol]
(R-HSA-9666997)
APC Q1328* [cytosol]
(R-HSA-9666998)
APC E1295* [cytosol]
(R-HSA-9666992)
APC E1151* [cytosol]
(R-HSA-9666993)
APC E1322* [cytosol]
(R-HSA-9666994)
APC E1345* [cytosol]
(R-HSA-9666995)
APC K1308* [cytosol]
(R-HSA-9666956)
APC S1344* [cytosol]
(R-HSA-9666957)
APC E1577* [cytosol]
(R-HSA-9666958)
APC Q1127* [cytosol]
(R-HSA-9666959)
APC E1464* [cytosol]
(R-HSA-9666952)
APC E1317* [cytosol]
(R-HSA-9666953)
APC G1309Dfs*4 [cytosol]
(R-HSA-4791251)
APC W1049* [cytosol]
(R-HSA-9666954)
APC Q1429* [cytosol]
(R-HSA-9666955)
APC L1564* [cytosol]
(R-HSA-9666948)
APC Q1294* [cytosol]
(R-HSA-9666949)
APC K1363* [cytosol]
(R-HSA-9666950)
APC E1408* [cytosol]
(R-HSA-9666951)
APC E1284* [cytosol]
(R-HSA-9666944)
APC E1374* [cytosol]
(R-HSA-9666945)
APC Q767* [cytosol]
(R-HSA-9666946)
APC E941* [cytosol]
(R-HSA-9666947)
APC Q1303* [cytosol]
(R-HSA-9666972)
APC S943* [cytosol]
(R-HSA-9666973)
APC E1306* [cytosol]
(R-HSA-9666975)
APC S895* [cytosol]
(R-HSA-9666969)
APC S1315* [cytosol]
(R-HSA-9666970)
APC G1412* [cytosol]
(R-HSA-9666971)
APC Y1376* [cytosol]
(R-HSA-9666964)
APC Q886* [cytosol]
(R-HSA-9666965)
APC S1392* [cytosol]
(R-HSA-9666966)
APC S1539* [cytosol]
(R-HSA-9666967)
APC E1451* [cytosol]
(R-HSA-9666960)
APC E1397* [cytosol]
(R-HSA-9666961)
APC Q1406* [cytosol]
(R-HSA-9666962)
APC E1544* [cytosol]
(R-HSA-9666963)
APC F1197* [cytosol]
(R-HSA-5246655)
APC Q1338* [cytosol]
(R-HSA-5246654)
APC S811* [cytosol]
(R-HSA-5246652)
APC I1417 fs*2 [cytosol]
(R-HSA-5246651)
APC E1554* [cytosol]
(R-HSA-5246648)
APC(1-777) [cytosol]
(R-HSA-2976014)
APC(778-2843) [cytosol]
(R-HSA-2976013)
APC [cytosol]
(R-HSA-2976015)
p-ub-APC [cytosol]
(R-HSA-3009421)
K63polyUb-APC [cytosol]
(R-HSA-5246690)
APC [nucleoplasm]
(R-HSA-3361755)
0.558
2
UniProt:P35968 KDR
4
VEGFR2(20-674)-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
p-11Y VEGFR2(20-674)-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
0.524
2
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