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LRP8 [plasma membrane]
Stable Identifier
R-HSA-432113
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
ApoER2, Low-density lipoprotein receptor-related protein 8, Apolipoprotein E receptor 2, LRP8_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet sensitization by LDL (Homo sapiens)
FGR binds LDL:LRP8 (Homo sapiens)
LDL:LRP8 [plasma membrane] (Homo sapiens)
LRP8 [plasma membrane] (Homo sapiens)
LDL:LRP8:FGR [plasma membrane] (Homo sapiens)
LDL:LRP8 [plasma membrane] (Homo sapiens)
LRP8 [plasma membrane] (Homo sapiens)
FGR binds and phosphorylates LRP8 (Homo sapiens)
LDL:LRP8:FGR [plasma membrane] (Homo sapiens)
LDL:LRP8 [plasma membrane] (Homo sapiens)
LRP8 [plasma membrane] (Homo sapiens)
LDL binds to LRP8 (Homo sapiens)
LDL:LRP8 [plasma membrane] (Homo sapiens)
LRP8 [plasma membrane] (Homo sapiens)
LRP8 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
LRPs [plasma membrane] (Homo sapiens)
LRP8 [plasma membrane] (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
LRPs [plasma membrane] (Homo sapiens)
LRP8 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14114 LRP8
Gene Names
LRP8, APOER2
Chain
signal peptide:1-32, chain:33-963
Reference Genes
BioGPS Gene:7804 LRP8
COSMIC (genes):LRP8 LRP8
CTD Gene:7804 LRP8
dbSNP Gene:7804 LRP8
ENSEMBL:ENSG00000157193 LRP8
ENSEMBL_homo_sapiens_GENE:ENSG00000157193.18 LRP8
HGNC:6700 LRP8
KEGG Gene (Homo sapiens):7804 LRP8
Monarch:7804 LRP8
NCBI Gene:7804 LRP8
OMIM:602600 LRP8
UCSC:Q14114 LRP8
Reference Transcript
RefSeq:NM_017522.4 LRP8
RefSeq:NM_033300.3 LRP8
RefSeq:NM_001018054.2 LRP8
RefSeq:NM_004631.4 LRP8
Other Identifiers
11724797_a_at
11724798_x_at
11728896_a_at
11741376_a_at
11747761_a_at
11747762_x_at
16687352
205282_PM_at
205282_at
208433_PM_s_at
208433_s_at
210092_PM_at
210092_at
228955_PM_at
228955_at
2413197
2413198
2413202
2413204
2413205
2413206
2413207
2413208
2413209
2413210
2413211
2413212
2413213
2413214
2413218
2413219
2413220
2413221
2413224
2413225
2413226
2413228
2413229
2413231
2413232
2413241
2413242
2413246
2413253
2413277
2413282
2413283
2413284
32398_s_at
40012_at
58519_at
58521_g_at
7804
7916282
A_23_P34325
A_32_P98979
D50678_at
GE62717
GO:0001523
GO:0001540
GO:0002376
GO:0004888
GO:0005041
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005856
GO:0005875
GO:0005886
GO:0005901
GO:0006351
GO:0006355
GO:0006508
GO:0006629
GO:0006897
GO:0007165
GO:0007268
GO:0008035
GO:0008092
GO:0009410
GO:0009986
GO:0012501
GO:0016020
GO:0016192
GO:0019221
GO:0019894
GO:0021517
GO:0021541
GO:0021766
GO:0021819
GO:0021987
GO:0023052
GO:0030154
GO:0030229
GO:0030424
GO:0030425
GO:0032793
GO:0034185
GO:0034330
GO:0036211
GO:0038024
GO:0038025
GO:0038026
GO:0042981
GO:0043025
GO:0043226
GO:0043235
GO:0045088
GO:0045202
GO:0046872
GO:0048306
GO:0048813
GO:0048856
GO:0048870
GO:0050731
GO:0050804
GO:0060089
GO:0061003
GO:0061098
GO:0071363
GO:0071397
GO:0098542
GO:1900006
HMNXSV003043039
Hs.27379.0.A1_3p_at
Hs.27379.0.A1_3p_x_at
ILMN_1677765
ILMN_2302654
PH_hs_0024845
PH_hs_0025145
TC01002669.hg
Z75190_s_at
g4758687_3p_at
g8923799_3p_a_at
Participates
as a member of
LRPs [plasma membrane] (Homo sapiens)
as an input of
LDL binds to LRP8 (Homo sapiens)
as a component of
LDL:LRP8 [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y-LRP8 [plasma membrane]
Inferred To
Lrp8 [plasma membrane]
(Rattus norvegicus)
LRP8 [plasma membrane]
(Bos taurus)
LRP8 [plasma membrane]
(Canis familiaris)
LRP8 [plasma membrane]
(Gallus gallus)
LRP8 [plasma membrane]
(Mus musculus)
LRP8 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_059992.3
,
NP_150643.2
,
NP_001018064.1
,
NP_004622.2
OpenTargets
ENSG00000157193
HPA
ENSG00000157193-LRP8
GeneCards
Q14114
Ensembl
ENSP00000346391
,
ENST00000347547
,
ENST00000306052
,
ENSP00000334522
,
ENST00000371454
,
ENSP00000303634
,
ENST00000354412
,
ENSG00000157193
,
ENSP00000360509
PRO
Q14114
Pharos - Targets
Q14114
PDB
5B4Y
,
7UCX
,
3A7Q
,
5B4X
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q60841
1
RELN [extracellular region]
(R-MMU-8854469)
0.769
10
UniProt:P30533 AMRP
0.564
2
UniProt:P25054 APC
20
APC R213* [cytosol]
(R-HSA-9666924)
APC C1410* [cytosol]
(R-HSA-9666925)
APC K1310* [cytosol]
(R-HSA-9666926)
APC R499* [cytosol]
(R-HSA-9666927)
APC R1450* [cytosol]
(R-HSA-5251499)
APC G1357* [cytosol]
(R-HSA-9666940)
APC L1488* [cytosol]
(R-HSA-9666941)
APC S1400* [cytosol]
(R-HSA-9666942)
APC S1346* [cytosol]
(R-HSA-9666943)
APC R405* [cytosol]
(R-HSA-9666936)
APC S1281* [cytosol]
(R-HSA-9666937)
APC E1573* [cytosol]
(R-HSA-9666938)
APC R805* [cytosol]
(R-HSA-9666939)
APC R1386* [cytosol]
(R-HSA-9666932)
APC S1327* [cytosol]
(R-HSA-9666933)
APC E1209* [cytosol]
(R-HSA-9666934)
APC Q1469* [cytosol]
(R-HSA-9666935)
APC R564* [cytosol]
(R-HSA-9666928)
APC E1536* [cytosol]
(R-HSA-9666929)
APC G1288* [cytosol]
(R-HSA-9666930)
0.558
2
UniProt:P35968 KDR
5
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
p-Y801,Y1054,Y1175-KDR [plasma membrane]
(R-HSA-9860484)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
0.471
2
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