Reactome | LRP8 [plasma membrane]

LRP8 [plasma membrane]

Stable Identifier

R-HSA-432113

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ApoER2, Low-density lipoprotein receptor-related protein 8, Apolipoprotein E receptor 2, LRP8_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q14114 LRP8

Gene Names

LRP8, APOER2

Chain

signal peptide:1-32, chain:33-963

Reference Genes

BioGPS Gene:7804 LRP8

COSMIC (genes):LRP8 LRP8

CTD Gene:7804 LRP8

dbSNP Gene:7804 LRP8

ENSEMBL:ENSG00000157193 LRP8

HGNC:6700 LRP8

KEGG Gene (Homo sapiens):7804 LRP8

Monarch:7804 LRP8

NCBI Gene:7804 LRP8

OMIM:602600 LRP8

UCSC:Q14114 LRP8

Reference Transcript

Other Identifiers

0003780059

0005690020

11724797_a_at

11724798_x_at

11728896_a_at

11741376_a_at

11747761_a_at

11747762_x_at

16687352

205282_at

208433_s_at

210092_at

228955_at

2413197

2413198

2413202

2413204

2413205

2413206

2413207

2413208

2413209

2413210

2413211

2413212

2413213

2413214

2413218

2413219

2413220

2413221

2413224

2413225

2413226

2413228

2413229

2413231

2413232

2413241

2413242

2413246

2413253

2413277

2413282

2413283

2413284

32398_s_at

40012_at

58519_at

58521_g_at

7804

7916282

A_23_P34325

A_32_P98979

D50678_at

GE62717

GO:0000902

GO:0001523

GO:0002376

GO:0003674

GO:0004888

GO:0005041

GO:0005509

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005856

GO:0005875

GO:0005886

GO:0005901

GO:0006464

GO:0006508

GO:0006629

GO:0006810

GO:0006897

GO:0006950

GO:0007165

GO:0007267

GO:0008035

GO:0008092

GO:0008150

GO:0008219

GO:0009058

GO:0014069

GO:0016020

GO:0016021

GO:0016192

GO:0019221

GO:0019894

GO:0021541

GO:0021987

GO:0030154

GO:0030229

GO:0030424

GO:0030425

GO:0032793

GO:0032991

GO:0034185

GO:0034330

GO:0034641

GO:0038024

GO:0038025

GO:0038026

GO:0042493

GO:0042981

GO:0043025

GO:0043167

GO:0043226

GO:0043235

GO:0045088

GO:0048856

GO:0050731

GO:0050804

GO:0061003

GO:0061098

GO:0071363

GO:0071397

GO:1900006

Hs.27379.0.A1_3p_at

Hs.27379.0.A1_3p_x_at

ILMN_1677765

ILMN_2302654

PH_hs_0024845

PH_hs_0025145

TC01002669.hg

Z75190_s_at

g4758687_3p_at

g8923799_3p_a_at

Participant Of

hasMember

LRPs [plasma membrane]

input

LDL binds to LRP8

hasComponent

LDL:LRP8 [plasma membrane]

Other forms of this molecule

p-Y-LRP8 [plasma membrane]

Inferred To

Lrp8 [plasma membrane] (Mus musculus)

Lrp8 [plasma membrane] (Rattus norvegicus)

LRP8 [plasma membrane] (Canis familiaris)

LRP8 [plasma membrane] (Sus scrofa)

fbxw7 [plasma membrane] (Xenopus tropicalis)

lrp8 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_004622.2, NP_150643.2, NP_001018064.1, NP_059992.3

OpenTargets

ENSG00000157193

GeneCards

Q14114

HPA

ENSG00000157193-LRP8

Ensembl

ENSP00000303634, ENSG00000157193, ENST00000371454, ENST00000347547, ENST00000306052, ENSP00000360509, ENSP00000334522, ENSP00000346391, ENST00000354412

PRO

Q14114

PDB

5B4X, 3A7Q, 5B4Y

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q60841	1	Reln [extracellular region] (R-MMU-8854469)	0.769	10
UniProt:P25054 APC	86	APC C1410* [cytosol] (R-HSA-9666925) APC R213* [cytosol] (R-HSA-9666924) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930) APC G1312* [cytosol] (R-HSA-9666931) APC R283* [cytosol] (R-HSA-9666988) APC Q1367* [cytosol] (R-HSA-9666989) APC E1353* [cytosol] (R-HSA-9666990) APC R332* [cytosol] (R-HSA-9666991) APC K993* [cytosol] (R-HSA-9666984) APC R876* [cytosol] (R-HSA-9666985) APC R302* [cytosol] (R-HSA-9666986) APC E1309* [cytosol] (R-HSA-9666987) APC Y935* [cytosol] (R-HSA-9666980) APC E1286* [cytosol] (R-HSA-9666981) APC Q1378* [cytosol] (R-HSA-9666982) APC R554* [cytosol] (R-HSA-9666983) APC S1356* [cytosol] (R-HSA-9666976) APC R232* [cytosol] (R-HSA-9666977) APC E1379* [cytosol] (R-HSA-9666978) APC E984* [cytosol] (R-HSA-9666979) APC R1114* [cytosol] (R-HSA-9666996) APC S1282* [cytosol] (R-HSA-9666997) APC Q1328* [cytosol] (R-HSA-9666998) APC E1295* [cytosol] (R-HSA-9666992) APC E1151* [cytosol] (R-HSA-9666993) APC E1322* [cytosol] (R-HSA-9666994) APC E1345* [cytosol] (R-HSA-9666995) APC K1308* [cytosol] (R-HSA-9666956) APC S1344* [cytosol] (R-HSA-9666957) APC E1577* [cytosol] (R-HSA-9666958) APC Q1127* [cytosol] (R-HSA-9666959) APC E1464* [cytosol] (R-HSA-9666952) APC E1317* [cytosol] (R-HSA-9666953) APC G1309Dfs4 [cytosol] (R-HSA-4791251) APC W1049 [cytosol] (R-HSA-9666954) APC Q1429* [cytosol] (R-HSA-9666955) APC L1564* [cytosol] (R-HSA-9666948) APC Q1294* [cytosol] (R-HSA-9666949) APC K1363* [cytosol] (R-HSA-9666950) APC E1408* [cytosol] (R-HSA-9666951) APC E1284* [cytosol] (R-HSA-9666944) APC E1374* [cytosol] (R-HSA-9666945) APC Q767* [cytosol] (R-HSA-9666946) APC E941* [cytosol] (R-HSA-9666947) APC Q1303* [cytosol] (R-HSA-9666972) APC S943* [cytosol] (R-HSA-9666973) APC E1306* [cytosol] (R-HSA-9666975) APC S895* [cytosol] (R-HSA-9666969) APC S1315* [cytosol] (R-HSA-9666970) APC G1412* [cytosol] (R-HSA-9666971) APC Y1376* [cytosol] (R-HSA-9666964) APC Q886* [cytosol] (R-HSA-9666965) APC S1392* [cytosol] (R-HSA-9666966) APC S1539* [cytosol] (R-HSA-9666967) APC E1451* [cytosol] (R-HSA-9666960) APC E1397* [cytosol] (R-HSA-9666961) APC Q1406* [cytosol] (R-HSA-9666962) APC E1544* [cytosol] (R-HSA-9666963) APC F1197* [cytosol] (R-HSA-5246655) APC Q1338* [cytosol] (R-HSA-5246654) APC S811* [cytosol] (R-HSA-5246652) APC I1417 fs2 [cytosol] (R-HSA-5246651) APC E1554 [cytosol] (R-HSA-5246648) APC(1-777) [cytosol] (R-HSA-2976014) APC(778-2843) [cytosol] (R-HSA-2976013) APC [cytosol] (R-HSA-2976015) p-ub-APC [cytosol] (R-HSA-3009421) K63polyUb-APC [cytosol] (R-HSA-5246690) APC [nucleoplasm] (R-HSA-3361755)	0.558	2
UniProt:P35968 KDR	4	VEGFR2(20-674)-PDGFRA(471-1089) fusion [plasma membrane] (R-HSA-9673613) p-11Y VEGFR2(20-674)-PDGFRA(471-1089) [plasma membrane] (R-HSA-9673636) VEGFR2 [plasma membrane] (R-HSA-195382) p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103)	0.524	2

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