FGR binds and phosphorylates LRP8

Stable Identifier
R-HSA-432129
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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FGR binds and phosphorylates LRP8
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Tyrosine phosphorylation of LDL:LRP8 is mediated by the Src-family kinase FGR, based on a correlation of increased LRP8 phosphorylation on LDL stimulation of platelets, and a transient increased co-precipitation of FGR with LRP8 upon LDL stimulation.
Literature References
PubMed ID Title Journal Year
15459198 Binding of low density lipoprotein to platelet apolipoprotein E receptor 2' results in phosphorylation of p38MAPK

Akkerman, JW, Gorter, G, Korporaal, SJ, Strasser, V, Lenting, PJ, Bezemer, M, Nimpf, J, van Eck, M, Relou, IA, van Berkel, TJ

J Biol Chem 2004
Participants
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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of LDL:LRP8:FGR [plasma membrane]

Physical Entity
LDL:LRP8:FGR [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
FGR binds and phosphorylates LRP8 (Bos taurus)
FGR binds and phosphorylates LRP8 (Canis familiaris)
FGR binds and phosphorylates LRP8 (Gallus gallus)
FGR binds and phosphorylates LRP8 (Mus musculus)
FGR binds and phosphorylates LRP8 (Rattus norvegicus)
FGR binds and phosphorylates LRP8 (Sus scrofa)
Authored
Akkerman, JW  (2009-09-04)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-08-11)
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