Reactome | AQP2 [transport vesicle membrane]

AQP2 [transport vesicle membrane]

Stable Identifier

R-HSA-432215

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

transport vesicle membrane

Synonyms

Aquaporin-2, AQP2_HUMAN

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External Reference Information

External Reference

UniProt:P41181 AQP2

Gene Names

AQP2

Chain

chain:1-271

Reference Genes

BioGPS Gene:359 AQP2

COSMIC (genes):AQP2 AQP2

CTD Gene:359 AQP2

dbSNP Gene:359 AQP2

ENSEMBL:ENSG00000167580 AQP2

HGNC:634 AQP2

KEGG:hsa:359 AQP2

Monarch:359 AQP2

NCBI Gene:359 AQP2

OMIM:107777 AQP2

UCSC:P41181 AQP2

Reference Transcript

RefSeq:NM_000486.5 AQP2

Other Identifiers

11729928_a_at

11729929_a_at

11729930_at

16750963

206672_PM_at

206672_at

236630_PM_at

236630_at

240285_PM_at

240285_at

3414304

3414305

3414307

3414308

3414309

3414310

3414311

3414312

3414313

3414314

3414316

359

39679_at

69563_at

73711_at

7955290

82074_at

A_14_P122083

A_23_P204721

A_24_P172685

A_33_P3304065

D31846_at

GE57167

GE86177

GE878817

GO:0003014

GO:0003091

GO:0003097

GO:0005215

GO:0005372

GO:0005515

GO:0005737

GO:0005768

GO:0005794

GO:0005886

GO:0006833

GO:0007015

GO:0015168

GO:0015250

GO:0015267

GO:0015793

GO:0016020

GO:0016323

GO:0016324

GO:0016328

GO:0030658

GO:0030659

GO:0031410

GO:0042631

GO:0043226

GO:0048471

GO:0048856

GO:0051289

GO:0055037

GO:0055085

GO:0065003

GO:0070062

GO:0071280

GO:0071288

GO:0072205

GO:0098576

HMNXSV003032001

Hs.130730.0.A1_3p_at

ILMN_1732149

ILMN_1773743

PH_hs_0007714

TC12000383.hg

g4755122_3p_at

Participates

as a component of

AQP2 tetramer [transport vesicle membrane] (Homo sapiens)

Other forms of this molecule

p-S256-AQP2 [transport vesicle membrane]

p-S256-AQP2 [plasma membrane]

Inferred To

AQP2 [transport vesicle membrane] (Bos taurus)

AQP2 [transport vesicle membrane] (Canis familiaris)

AQP2 [transport vesicle membrane] (Dictyostelium discoideum)

AQP2 [transport vesicle membrane] (Gallus gallus)

AQP2 [transport vesicle membrane] (Plasmodium falciparum)

AQP2 [transport vesicle membrane] (Sus scrofa)

Eglp2 [transport vesicle membrane] (Drosophila melanogaster)

Prip [transport vesicle membrane] (Drosophila melanogaster)

Aqp2 [transport vesicle membrane] (Mus musculus)

Aqp2 [transport vesicle membrane] (Rattus norvegicus)

mipa [transport vesicle membrane] (Danio rerio)

wacA [transport vesicle membrane] (Dictyostelium discoideum)

Drip [transport vesicle membrane] (Drosophila melanogaster)

Ghost homologue of AQP2 [transport vesicle membrane] (Xenopus tropicalis)

mipb [transport vesicle membrane] (Danio rerio)

Eglp1 [transport vesicle membrane] (Drosophila melanogaster)

Eglp3 [transport vesicle membrane] (Drosophila melanogaster)

bib [transport vesicle membrane] (Drosophila melanogaster)

aqpA [transport vesicle membrane] (Dictyostelium discoideum)

Homologues of AQP2 [transport vesicle membrane] (Danio rerio)

Homologues of AQP2 [transport vesicle membrane] (Dictyostelium discoideum)

Homologues of AQP2 [transport vesicle membrane] (Drosophila melanogaster)

Eglp4 [transport vesicle membrane] (Drosophila melanogaster)

Cross References

Guide to Pharmacology - Targets

689

ENSEMBL

ENST00000199280, ENSP00000199280

OpenTargets

ENSG00000167580

HPA

ENSG00000167580-AQP2

PRO

P41181

Pharos - Targets

P41181

GlyGen

P41181

Orphanet

AQP2

HMDB Protein

HMDBP02881

PDB

8OEE, 6QF5, 4NEF, 8GCL, 4OJ2, 8GHJ

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.556	3
UniProt:P24593 IGFBP5	5	IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956738) p-IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956988) IGFBP5 [extracellular region] (R-HSA-381414) IGFBP5(21-163) [extracellular region] (R-HSA-381415) IGFBP5(164-272) [extracellular region] (R-HSA-381478)	0.556	3
UniProt:Q01453 PMP22	1	PMP22 [plasma membrane] (R-HSA-9615623)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:A8MZ59 LEUTX	1	LEUTX [nucleoplasm] (R-HSA-9817277)	0.556	3
UniProt:Q6IN84 MRM1	1	MRM1 [mitochondrial matrix] (R-HSA-6793088)	0.556	3
UniProt:Q5QGT7 RTP2	2	RTP2 [endoplasmic reticulum membrane] (R-HSA-9752982) RTP2 [plasma membrane] (R-HSA-8939446)	0.556	3

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