Reactome | ARRB1 [lysosomal membrane]

ARRB1 [lysosomal membrane]

Stable Identifier

R-HSA-432701

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal membrane

Synonyms

Beta-arrestin-1, ARRB1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P49407 ARRB1

Gene Names

ARRB1, ARR1

Chain

chain:1-418

Reference Genes

BioGPS Gene:408 ARRB1

COSMIC (genes):ARRB1 ARRB1

CTD Gene:408 ARRB1

dbSNP Gene:408 ARRB1

ENSEMBL:ENSG00000137486 ARRB1

HGNC:711 ARRB1

KEGG:hsa:408 ARRB1

Monarch:408 ARRB1

NCBI Gene:408 ARRB1

OMIM:107940 ARRB1

UCSC:P49407 ARRB1

Reference Transcript

Other Identifiers

11742838_at

11760185_s_at

16742202

218832_PM_x_at

218832_x_at

221861_PM_at

221861_at

222756_PM_s_at

222756_s_at

222912_PM_at

222912_at

228444_PM_at

228444_at

3382217

3382218

3382219

3382220

3382221

3382222

3382224

3382225

3382228

3382229

3382230

3382231

3382232

3382233

3382234

3382236

3382237

3382238

3382239

3382240

3382241

3382242

3382243

3382246

3382247

3382252

3382258

3382259

3382261

3382278

3382279

3382280

408

43511_PM_s_at

43511_s_at

49111_PM_at

49111_at

58259_at

59336_at

78529_at

7950473

A_23_P203702

A_24_P386622

GE54737

GE87006

GO:0000139

GO:0000785

GO:0001664

GO:0001934

GO:0002031

GO:0002092

GO:0003713

GO:0004857

GO:0005096

GO:0005159

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005765

GO:0005829

GO:0005886

GO:0005905

GO:0006355

GO:0006357

GO:0006511

GO:0007010

GO:0007165

GO:0007601

GO:0009968

GO:0015031

GO:0016192

GO:0016567

GO:0016604

GO:0030163

GO:0030659

GO:0030666

GO:0031143

GO:0031397

GO:0031410

GO:0031625

GO:0031701

GO:0031982

GO:0032088

GO:0032715

GO:0032717

GO:0035025

GO:0042995

GO:0043149

GO:0043161

GO:0043226

GO:0045746

GO:0045944

GO:0050877

GO:0060090

GO:0070374

GO:0098772

GO:0140110

GO:1990763

HMNXSV003025489

HMNXSV003033637

Hs.112278.0.S2_3p_at

Hs.112278.0.S2_3p_x_at

Hs.112278.2.A1_3p_at

Hs.22483.0.S1_3p_at

Hs.22483.0.S1_3p_s_at

ILMN_1730620

ILMN_1819608

ILMN_1875302

ILMN_2325168

PH_hs_0006154

TC11002092.hg

g10880135_3p_a_at

Participates

as a component of

Lysosome Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [lysosomal membrane] (Homo sapiens)

Other forms of this molecule

ARRB1 [cytosol]

PolyUb-ARRB1 [cytosol]

ARRB1 [endocytic vesicle membrane]

ARRB1 [Golgi membrane]

ARRB1 [cytoplasmic vesicle membrane]

Inferred To

Arr2 [lysosomal membrane] (Drosophila melanogaster)

krz [lysosomal membrane] (Drosophila melanogaster)

ARRB1 [lysosomal membrane] (Bos taurus)

ARRB1 [lysosomal membrane] (Canis familiaris)

ARRB1 [lysosomal membrane] (Mus musculus)

ARRB1 [lysosomal membrane] (Rattus norvegicus)

ARRB1 [lysosomal membrane] (Sus scrofa)

Homologues of ARRB1 [lysosomal membrane] (Drosophila melanogaster)

CG15303 [lysosomal membrane] (Drosophila melanogaster)

Arr1 [lysosomal membrane] (Drosophila melanogaster)

arr-1 [lysosomal membrane] (Caenorhabditis elegans)

arrb1 [lysosomal membrane] (Danio rerio)

arrb1 [lysosomal membrane] (Xenopus tropicalis)

Ghost homologue of ARRB1 [lysosomal membrane] (Dictyostelium discoideum)

Ghost homologue of ARRB1 [lysosomal membrane] (Gallus gallus)

Cross References

RefSeq

NP_064647.1, NP_004032.2

OpenTargets

ENSG00000137486

ENSEMBL

ENSP00000409581, ENSP00000353124, ENST00000360025, ENST00000420843

HPA

ENSG00000137486-ARRB1

PRO

P49407

Pharos - Targets

P49407

GlyGen

P49407

PDB

2IV8, 7R0C, 7SRS, 6TKO, 8JRV, 8WRZ, 8AS3, 8AS4, 8AS2, 6UP7, 7R0J, 6PWC

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14749 GNMT	1	GNMT [cytosol] (R-HSA-5357674)	0.893	12
UniProt:P45984 MAPK9	3	MAPK9 [cytosol] (R-HSA-450355) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319)	0.841	9
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.744	10
UniProt:O43298 ZBT43			0.742	5
UniProt:Q14978 NOLC1			0.723	7
UniProt:P20963 CD247			0.644	9
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.641	3
UniProt:O95218 ZRAB2			0.641	5
UniProt:Q13428 TCOF			0.641	4
UniProt:Q5JWF2 GNAS	1	GNAS1 [plasma membrane] (R-HSA-8873940)	0.639	5
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.623	3
UniProt:P53779 MAPK10	3	p-T221,Y223-MAPK10 [nucleoplasm] (R-HSA-450311) p-T221,Y223-MAPK10 [cytosol] (R-HSA-450214) MAPK10 [cytosol] (R-HSA-450352)	0.609	2
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.602	4
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.577	3
UniProt:Q7Z4V5 HDGR2			0.564	3
UniProt:Q92541 RTF1	1	RTF1 [nucleoplasm] (R-HSA-8866693)	0.564	2
UniProt:P36575 ARRC			0.564	3
UniProt:P14859-6 POU2F1			0.556	3
IntAct:EBI-22312375 CCSB ORF ID			0.556	3
UniProt:P63010-2 AP2B1			0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:O00459 PIK3R2	3	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554) p-Y464-PIK3R2 [cytosol] (R-HSA-9860512)	0.547	2
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.544	3
UniProt:P10523 SAG	1	SAG [cytosol] (R-HSA-50320)	0.527	4
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.527	4
UniProt:P50148 GNAQ	1	GNAQ [plasma membrane] (R-HSA-55453)	0.524	2
UniProt:Q7DB77 TIR			0.508	3
UniProt:P19338 NCL	3	NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.499	3
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) ub-AXIN1 [cytosol] (R-HSA-4641133) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.499	2
UniProt:P97288	1	HTR4 [plasma membrane] (R-MMU-391008)	0.499	5
UniProt:P62158 CALM			0.499	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.499	5
UniProt:P06702 S100A9	3	S100A9 [cytosol] (R-HSA-9626869) S100A9 [secretory granule lumen] (R-HSA-6804774) S100A9 [extracellular region] (R-HSA-5432857)	0.499	2
UniProt:P25101 EDNRA	1	EDNRA [plasma membrane] (R-HSA-388549)	0.499	3
UniProt:Q15208 STK38	1	STK38 [cytosol] (R-HSA-9715143)	0.499	3
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.499	3
UniProt:P14618 PKM	3	PKM [ficolin-1-rich granule lumen] (R-HSA-6801387) PKM [extracellular region] (R-HSA-6806491) PKM [secretory granule lumen] (R-HSA-6801401)	0.499	3
UniProt:O75688 PPM1B	3	PPM1B(2-282)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713479) PPM1B(2-282)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713477) PPM1B [cytosol] (R-HSA-1169375)	0.499	4
UniProt:P35813 PPM1A	2	PPM1A [nucleoplasm] (R-HSA-205813) PPM1A [cytosol] (R-HSA-380928)	0.499	4
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.499	4
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940)	0.499	3
UniProt:Q00610 CLTC	10	CLTC [trans-Golgi network membrane] (R-HSA-5333703) CLTC [cytosol] (R-HSA-8856820) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol] (R-HSA-9710852) CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710854) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9710835) CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710853) CLTC [endolysosome membrane] (R-HSA-8870827) CLTC [clathrin-coated endocytic vesicle membrane] (R-HSA-5138450) CLTC [lysosomal membrane] (R-HSA-2980660) CLTC [plasma membrane] (R-HSA-2980668)	0.491	3
UniProt:Q16665 HIF1A	7	HIF1A [nucleoplasm] (R-HSA-1234135) HIF1A [cytosol] (R-HSA-1234102) p-Y565-HIF1A [cytosol] (R-HSA-8857584) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) 2xHP-HIF1A [cytosol] (R-HSA-1234131) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110)	0.463	3
UniProt:P25106 ACKR3	1	CXCR7 [plasma membrane] (R-HSA-373859)	0.463	2

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