trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly

Stable Identifier
Reaction [dissociation]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Once the basic components of the docking complex are assembled with one end of AP-1 bound to cargo molecules, the other end binds to clathrin. Clathrin triskelions polymerize into hexagons and pentagons, forming a cage, which leads to membrane deformation. This polymerization step drives the sculpting of the lysosome vesicle. Here only 5 clathrin triskelions are represented, though in reality many more would be involved in sculpting an entire vesicle.

Literature References
PubMed ID Title Journal Year
10394364 Functional organization of clathrin in coats: combining electron cryomicroscopy and X-ray crystallography

Musacchio, A, Smith, CJ, Roseman, AM, Harrison, SC, Kirchhausen, Tomas, Pearse, BM

Mol Cell 1999
11994746 Regulated transport of the glucose transporter GLUT4.

Bryant, NJ, Govers, R, James, DE

Nat Rev Mol Cell Biol 2002
Participant Of
Orthologous Events
Cite Us!