Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane

Stable Identifier
R-HSA-432712
Type
Reaction
Species
Homo sapiens
Compartment
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Once AP-1 is recruited to the trans-Golgi Network membrane the complex of functional vesicle building proteins is joined by the cargo that will be within that vesicle. As with other types of vesicles the cargo itself is part of the vesicle development. Here the cargo is destined for the lysosome membrane. It is at this stage that a specific Synaptobrevin (Vamp) molecule also joins the complex. It should be noted that only certain Vamp molecules will be found with specific cargo molecules on the newly forming vesicles. However here we represent this reaction in bulk, without specific Vamp and cargo molecule pairings.

Literature References
PubMed ID Title Journal Year
11994746 Regulated transport of the glucose transporter GLUT4.

Bryant, NJ, Govers, R, James, DE

Nat Rev Mol Cell Biol 2002
11694590 GGAs: roles of the different domains and comparison with AP-1 and clathrin

Hirst, J, Lindsay, MR, Robinson, MS

Mol Biol Cell 2001
17116749 Comparative proteomics of clathrin-coated vesicles

Borner, GH, Harbour, M, Hester, S, Lilley, KS, Robinson, MS

J Cell Biol 2006
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