Reactome | p-T286-CAMK2A [plasma membrane]

p-T286-CAMK2A [plasma membrane]

Stable Identifier

R-HSA-432796

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Ca/Calmodulin dependent protein kinase II alpha subunit

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UQM7 CAMK2A

Gene Names

CAMK2A, CAMKA, KIAA0968

Chain

chain:1-478

Reference Genes

BioGPS Gene:815 CAMK2A

COSMIC (genes):CAMK2A CAMK2A

CTD Gene:815 CAMK2A

dbSNP Gene:815 CAMK2A

ENSEMBL:ENSG00000070808 CAMK2A

HGNC:1460 CAMK2A

KEGG:hsa:815 CAMK2A

Monarch:815 CAMK2A

NCBI Gene:815 CAMK2A

OMIM:114078 CAMK2A

UCSC:Q9UQM7 CAMK2A

Reference Transcript

RefSeq:NM_171825.2 CAMK2A

Other Identifiers

11725935_at

11725936_a_at

17001617

207613_PM_s_at

207613_s_at

213108_PM_at

213108_at

2881301

2881302

2881303

2881304

2881305

2881306

2881309

2881313

2881316

2881317

2881318

2881320

2881321

2881322

2881323

2881324

2881325

2881328

2881329

2881330

2881332

2881333

2881334

2881335

2881336

2881338

2881342

2881343

2881344

2881345

2881346

31813_at

8115122

815

A_24_P380311

A_33_P3274647

GE53630

GO:0000082

GO:0002931

GO:0003824

GO:0004672

GO:0004674

GO:0004683

GO:0005515

GO:0005516

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005954

GO:0006355

GO:0006468

GO:0006816

GO:0007005

GO:0010666

GO:0014069

GO:0016301

GO:0016740

GO:0018105

GO:0030425

GO:0030666

GO:0035254

GO:0035458

GO:0038166

GO:0042802

GO:0042803

GO:0042995

GO:0043005

GO:0043197

GO:0043226

GO:0045202

GO:0046427

GO:0046777

GO:0046872

GO:0046928

GO:0048168

GO:0048856

GO:0051092

GO:0051346

GO:0051928

GO:0060996

GO:0061024

GO:0071346

GO:0106310

GO:0140096

GO:1902108

GO:1990443

GO:2000124

GO:2001222

HMNXSV003022286

Hs.143535.1.S2_3p_at

Hs.143535.1.S2_3p_x_at

ILMN_1666445

ILMN_1838586

PH_hs_0008445

TC05001934.hg

g7706285_3p_a_at

Participates

as a member of

p-CAMK2A, p-CAMK2B [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-T286-CAMK2A [cytosol]

CAMK2A [cytosol]

p-T286,T305,T306-CAMK2A [cytosol]

p-T286-CAMK2A [endocytic vesicle membrane]

p-T286-CAMK2A [nucleoplasm]

Inferred To

phospho-CAMK2A [plasma membrane] (Canis familiaris)

phospho-CAMK2A [plasma membrane] (Gallus gallus)

phospho-p-T286-CAMK2A [plasma membrane] (Bos taurus)

phospho-p-T286-CAMK2A [plasma membrane] (Caenorhabditis elegans)

phospho-p-T286-CAMK2A [plasma membrane] (Drosophila melanogaster)

phospho-p-T286-CAMK2A [plasma membrane] (Mus musculus)

phospho-p-T286-CAMK2A [plasma membrane] (Plasmodium falciparum)

phospho-p-T286-CAMK2A [plasma membrane] (Rattus norvegicus)

phospho-p-T286-CAMK2A [plasma membrane] (Sus scrofa)

Modified Residues

Name

O-phospho-L-threonine at 286

Coordinate

286

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_741960.1

Guide to Pharmacology - Targets

1555

OpenTargets

ENSG00000070808

ENSEMBL

ENSP00000500386, ENST00000672479, ENST00000682786, ENSP00000261793, ENSG00000070808, ENST00000671881, ENSP00000507199, ENST00000348628, ENSP00000500642

ZINC - FDA approved

KCC2A_HUMAN

ZINC - Substances

KCC2A_HUMAN

ZINC - Biogenic

KCC2A_HUMAN

ZINC target

Q9UQM7

PRO

Q9UQM7

GlyGen

Q9UQM7

PDB

2VZ6, 6X5Q, 6W4P, 6W4O, 9EOY, 7REC, 3SOA, 7KL1, 7KL2, 7UJQ, 7KL0, 7UJS, 6VZK, 7UIR, 7UJP, 7UJR, 6OF8, 7UIQ, 7UJT, 7UIS, 6X5G, 5IG3

ZINC - Investigational

KCC2A_HUMAN

HPA

ENSG00000070808-CAMK2A

GeneCards

CAMK2A

Pharos - Targets

Q9UQM7

ZINC - Predictions - Purchasable

KCC2A_HUMAN

Orphanet

CAMK2A

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.666	5
UniProt:Q13224 GRIN2B	6	GRIN2B [plasma membrane] (R-HSA-419558) p-Y-GRIN2B [plasma membrane] (R-HSA-9612185) GRIN2B [endoplasmic reticulum membrane] (R-HSA-9609765) GRIN2B [transport vesicle membrane] (R-HSA-9610568) p-Y1474-GRIN2B [plasma membrane] (R-HSA-9032602) p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane] (R-HSA-3928477)	0.602	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.564	3
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.556	3
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.556	3
UniProt:O14494 PLPP1	1	PLPP1 [plasma membrane] (R-HSA-76106)	0.556	3
UniProt:P26640 VARS1	1	VARS [cytosol] (R-HSA-379648)	0.556	3
UniProt:P20339 RAB5A	7	RAB5A [cytosol] (R-HSA-2201187) GGC-RAB5A [macropinosome membrane] (R-HSA-9837697) RAB5A [endosome membrane] (R-HSA-452257) RAB5A [early endosome membrane] (R-HSA-2130175) GGC-RAB5A [cytosol] (R-HSA-8870432) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125)	0.556	3
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.556	3
UniProt:Q8N0Z6 TTC5	3	p-S203,S221-TTC5 [nucleoplasm] (R-HSA-6804259) p-S203-TTC5 [nucleoplasm] (R-HSA-6804261) TTC5 [nucleoplasm] (R-HSA-6804264)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:P16284 PECAM1	5	PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:P12814 ACTN1	3	ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [extracellular region] (R-HSA-349722) ACTN1 [cytosol] (R-HSA-354096)	0.519	2

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