Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
p-T286-CAMK2A [plasma membrane]
Stable Identifier
R-HSA-432796
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Ca/Calmodulin dependent protein kinase II alpha subunit
Icon
Locations in the PathwayBrowser
Expand all
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Homo sapiens)
CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] (Homo sapiens)
CAMK2 heteromer [plasma membrane] (Homo sapiens)
p-CAMK2A, p-CAMK2B [plasma membrane] (Homo sapiens)
p-T286-CAMK2A [plasma membrane] (Homo sapiens)
Phase 0 - rapid depolarisation (Homo sapiens)
SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Homo sapiens)
CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] (Homo sapiens)
CAMK2 heteromer [plasma membrane] (Homo sapiens)
p-CAMK2A, p-CAMK2B [plasma membrane] (Homo sapiens)
p-T286-CAMK2A [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Ion transport by P-type ATPases (Homo sapiens)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Homo sapiens)
CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] (Homo sapiens)
CAMK2 heteromer [plasma membrane] (Homo sapiens)
p-CAMK2A, p-CAMK2B [plasma membrane] (Homo sapiens)
p-T286-CAMK2A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UQM7 CAMK2A
Gene Names
CAMK2A, CAMKA, KIAA0968
Chain
chain:1-478
Reference Genes
BioGPS Gene:815 CAMK2A
COSMIC (genes):CAMK2A CAMK2A
CTD Gene:815 CAMK2A
dbSNP Gene:815 CAMK2A
ENSEMBL:ENSG00000070808 CAMK2A
ENSEMBL:ENSG00000070808.17 CAMK2A
HGNC:1460 CAMK2A
KEGG Gene (Homo sapiens):815 CAMK2A
Monarch:815 CAMK2A
NCBI Gene:815 CAMK2A
OMIM:114078 CAMK2A
UCSC:Q9UQM7 CAMK2A
Reference Transcript
RefSeq:NM_171825.2 CAMK2A
Other Identifiers
11725935_at
11725936_a_at
17001617
207613_PM_s_at
207613_s_at
213108_PM_at
213108_at
2881301
2881302
2881303
2881304
2881305
2881309
2881313
2881318
2881320
2881321
2881323
2881324
2881325
2881328
2881329
2881330
2881332
2881333
2881334
2881335
2881336
2881338
2881342
2881343
2881344
2881345
2881346
31813_at
8115122
815
A_24_P380311
A_33_P3274647
GE53630
GO:0000082
GO:0000166
GO:0000278
GO:0002376
GO:0002931
GO:0003824
GO:0004672
GO:0004674
GO:0004683
GO:0005515
GO:0005516
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005954
GO:0006351
GO:0006355
GO:0006468
GO:0006816
GO:0007005
GO:0010666
GO:0012501
GO:0014069
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0023052
GO:0030154
GO:0030425
GO:0030666
GO:0031410
GO:0035254
GO:0035458
GO:0036211
GO:0038166
GO:0042802
GO:0042803
GO:0042995
GO:0043005
GO:0043197
GO:0043226
GO:0045202
GO:0046427
GO:0046777
GO:0046872
GO:0046928
GO:0048168
GO:0048856
GO:0048870
GO:0051092
GO:0051346
GO:0051928
GO:0060996
GO:0061024
GO:0071346
GO:0098542
GO:0106310
GO:0140096
GO:1902108
GO:1990443
GO:2000124
GO:2001222
HMNXSV003022286
Hs.143535.1.S2_3p_at
Hs.143535.1.S2_3p_x_at
ILMN_1666445
ILMN_1838586
PH_hs_0008445
TC05001934.hg
g7706285_3p_a_at
Participates
as a member of
p-CAMK2A, p-CAMK2B [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-T286-CAMK2A [nucleoplasm]
p-T286-CAMK2A [endocytic vesicle membrane]
p-T286,T305,T306-CAMK2A [cytosol]
CAMK2A [cytosol]
p-T286-CAMK2A [cytosol]
Inferred To
phospho-p-T286-CAMK2A [plasma membrane]
(Bos taurus)
phospho-p-T286-CAMK2A [plasma membrane]
(Caenorhabditis elegans)
phospho-p-T286-CAMK2A [plasma membrane]
(Canis familiaris)
phospho-p-T286-CAMK2A [plasma membrane]
(Danio rerio)
phospho-p-T286-CAMK2A [plasma membrane]
(Drosophila melanogaster)
phospho-p-T286-CAMK2A [plasma membrane]
(Mus musculus)
phospho-p-T286-CAMK2A [plasma membrane]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-threonine at 286
Coordinate
286
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_741960.1
ZINC - World Drugs
KCC2A_HUMAN
Guide to Pharmacology - Targets
1555
OpenTargets
ENSG00000070808
ZINC - FDA approved
KCC2A_HUMAN
ZINC - Substances
KCC2A_HUMAN
ZINC target
Q9UQM7
ZINC - Biogenic
KCC2A_HUMAN
PRO
Q9UQM7
PDB
5IG3
,
6VZK
,
6X5Q
,
7KL0
,
7UIQ
,
7UJQ
,
6W4P
,
6W4O
,
6OF8
,
7UJT
,
6X5G
,
7UJP
,
2VZ6
,
3SOA
,
7UJS
,
7KL2
,
7REC
,
7UIS
,
7UIR
,
7KL1
,
7UJR
ZINC - Investigational
KCC2A_HUMAN
GeneCards
Q9UQM7
HPA
ENSG00000070808-CAMK2A
Ensembl
ENST00000672479
,
ENST00000671881
,
ENSP00000500386
,
ENSP00000261793
,
ENST00000348628
,
ENSG00000070808
,
ENSP00000507199
,
ENST00000682786
,
ENSP00000500642
Pharos - Targets
Q9UQM7
ZINC - Predictions - Purchasable
KCC2A_HUMAN
Orphanet
25937
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07900 HSP90AA1
8
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.666
5
UniProt:Q13224 GRIN2B
6
p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane]
(R-HSA-3928477)
p-Y1474-GRIN2B [plasma membrane]
(R-HSA-9032602)
p-Y-GRIN2B [plasma membrane]
(R-HSA-9612185)
GRIN2B [transport vesicle membrane]
(R-HSA-9610568)
GRIN2B [endoplasmic reticulum membrane]
(R-HSA-9609765)
GRIN2B [plasma membrane]
(R-HSA-419558)
0.602
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
3
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:P16284 PECAM1
4
PECAM1 [plasma membrane]
(R-HSA-114686)
PECAM1 [secretory granule membrane]
(R-HSA-6804778)
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(R-HSA-210007)
PECAM1 [platelet alpha granule membrane]
(R-HSA-61489)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P04271 S100B
1
S100B [extracellular region]
(R-HSA-879433)
0.556
3
UniProt:P31749 AKT1
13
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.556
3
UniProt:P20339 RAB5A
6
GGC-RAB5A [clathrin-coated endocytic vesicle membrane]
(R-HSA-8871125)
GGC-RAB5A [early endosome membrane]
(R-HSA-8875323)
RAB5A [cytosol]
(R-HSA-2201187)
RAB5A [endosome membrane]
(R-HSA-452257)
RAB5A [early endosome membrane]
(R-HSA-2130175)
GGC-RAB5A [cytosol]
(R-HSA-8870432)
0.556
3
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.556
3
UniProt:O14494 PLPP1
1
PPAP2A [plasma membrane]
(R-HSA-76106)
0.556
3
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
0.556
3
UniProt:Q8N0Z6 TTC5
3
TTC5 [nucleoplasm]
(R-HSA-6804264)
p-S203-TTC5 [nucleoplasm]
(R-HSA-6804261)
p-S203,S221-TTC5 [nucleoplasm]
(R-HSA-6804259)
0.556
3
UniProt:P26640 VARS1
1
VARS [cytosol]
(R-HSA-379648)
0.556
3
UniProt:P12814 ACTN1
3
ACTN1 [cytosol]
(R-HSA-354096)
ACTN1 [platelet alpha granule lumen]
(R-HSA-349724)
ACTN1 [extracellular region]
(R-HSA-349722)
0.519
2
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text