Reactome | ILK [cytosol]

ILK [cytosol]

Stable Identifier

R-HSA-432864

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Integrin-linked protein kinase, ILK_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13418 ILK

Gene Names

ILK, ILK1, ILK2

Chain

chain:1-452

Reference Genes

BioGPS Gene:3611 ILK

COSMIC (genes):ILK ILK

CTD Gene:3611 ILK

dbSNP Gene:3611 ILK

ENSEMBL:ENSG00000166333 ILK

HGNC:6040 ILK

KEGG Gene (Homo sapiens):3611 ILK

Monarch:3611 ILK

NCBI Gene:3611 ILK

OMIM:602366 ILK

UCSC:Q13418 ILK

Reference Transcript

Other Identifiers

11724913_s_at

16721479

201234_at

3318891

3318892

3318893

3318894

3318895

3318896

3318901

3318903

3318904

3318906

3318908

3318910

3318911

3318912

3318913

3318914

3318915

3318916

35365_at

3611

7938154

A_14_P124609

A_23_P105066

A_24_P406870

GE59135

GE88667

GO:0000166

GO:0000902

GO:0001558

GO:0001658

GO:0001725

GO:0001934

GO:0001954

GO:0003151

GO:0003674

GO:0004672

GO:0004674

GO:0005178

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0005925

GO:0006464

GO:0006468

GO:0006469

GO:0006950

GO:0007010

GO:0007049

GO:0007050

GO:0007155

GO:0007160

GO:0007165

GO:0007229

GO:0007267

GO:0007568

GO:0007569

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0009058

GO:0009967

GO:0010667

GO:0010761

GO:0014044

GO:0014912

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0017124

GO:0018105

GO:0019899

GO:0019901

GO:0019904

GO:0021675

GO:0022011

GO:0022607

GO:0030017

GO:0030027

GO:0030030

GO:0030054

GO:0030154

GO:0030335

GO:0030424

GO:0030513

GO:0032288

GO:0032956

GO:0032991

GO:0033209

GO:0034329

GO:0034330

GO:0034446

GO:0034641

GO:0040007

GO:0040011

GO:0042327

GO:0042995

GO:0043025

GO:0043034

GO:0043066

GO:0043167

GO:0043195

GO:0043198

GO:0043226

GO:0043406

GO:0043410

GO:0043491

GO:0043524

GO:0044877

GO:0045197

GO:0045663

GO:0045669

GO:0045773

GO:0045893

GO:0048646

GO:0048662

GO:0048812

GO:0048856

GO:0048870

GO:0050772

GO:0050775

GO:0051897

GO:0070527

GO:0090263

GO:0097435

GO:1901224

GO:2000178

ILMN_1693514

ILMN_1732827

ILMN_2358980

ILMN_2364376

TC11000133.hg

U40282_at

g4758605_3p_s_at

Participant Of

hasComponent

input

Inferred To

Ilk [cytosol] (Drosophila melanogaster)

Ilk [cytosol] (Mus musculus)

Ilk [cytosol] (Rattus norvegicus)

pat-4 [cytosol] (Caenorhabditis elegans)

ilk [cytosol] (Danio rerio)

shkE [cytosol] (Dictyostelium discoideum)

shkC [cytosol] (Dictyostelium discoideum)

ILK [cytosol] (Canis familiaris)

ILK [cytosol] (Dictyostelium discoideum)

ILK [cytosol] (Plasmodium falciparum)

ILK [cytosol] (Sus scrofa)

ILK [cytosol] (Xenopus tropicalis)

drkD [cytosol] (Dictyostelium discoideum)

Homologues of ILK [cytosol] (Dictyostelium discoideum)

shkA [cytosol] (Dictyostelium discoideum)

shkD [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

XP_005252961.1, XP_005252962.1, XP_011518367.1, NP_004508.1, NP_001265370.1, NP_001265371.1, NP_001014794.1, NP_001014795.1

OpenTargets

ENSG00000166333

IntEnz

2.7.11.1

ZINC - Substances

ILK_HUMAN

HPA

ENSG00000166333-ILK

GeneCards

Q13418

ZINC target

Q13418

Ensembl

ENST00000396751, ENSG00000166333, ENSP00000434492, ENST00000528995, ENSP00000435323, ENSP00000403487, ENSP00000299421, ENST00000420936, ENST00000299421, ENSP00000379975, ENST00000532063

PRO

Q13418

ZINC - Predictions - Purchasable

ILK_HUMAN

HMDB Protein

HMDBP01460

PDB

2KBX, 6MIB, 3REP, 3KMW, 4HI8, 3IXE, 4HI9, 3F6Q, 3KMU

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NVD7 PARVA	1	PARVA [cytosol] (R-HSA-432848)	0.965	23
UniProt:P48059 LIMS1	1	LIMS1 [cytosol] (R-HSA-432859)	0.952	14
UniProt:Q9HBI0 PARVG			0.831	12
UniProt:Q15404 RSU1	1	RSU1 [cytosol] (R-HSA-446297)	0.802	5
UniProt:Q9HBI1 PARVB	1	PARVB [cytosol] (R-HSA-446016)	0.744	4
UniProt:O60762 DPM1	4	DPM1 Q210Rfs4 [endoplasmic reticulum membrane] (R-HSA-4717361) DPM1 R92G [endoplasmic reticulum membrane] (R-HSA-4717370) DPM1 G111Lfs45 [endoplasmic reticulum membrane] (R-HSA-4717383) DPM1 [endoplasmic reticulum membrane] (R-HSA-162865)	0.669	3
UniProt:P49023 PXN	4	PXN [plasma membrane] (R-HSA-180493) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.669	4
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.666	4
UniProt:Q6R327 RICTOR	1	RICTOR [cytosol] (R-HSA-198632)	0.659	8
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.643	3
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.643	3
UniProt:P50990 CCT8	5	CCT8 [extracellular region] (R-HSA-6806238) CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [cytosol] (R-HSA-390449)	0.643	3
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.643	3
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.643	3
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.643	3
UniProt:P27708 CAD	1	CAD [cytosol] (R-HSA-73452)	0.643	3
UniProt:P04049 RAF1	54	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098) p-S621-RAF1 G361A [cytosol] (R-HSA-9656092) p-S621-RAF1 G370R [cytosol] (R-HSA-9656094) p-S621-RAF1 D486G [cytosol] (R-HSA-9656085) p-S621-RAF1 T491R [cytosol] (R-HSA-9656145) p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol] (R-HSA-9656026) p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol] (R-HSA-9656070) p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol] (R-HSA-9656035) p-S338,Y341,S494,S621-RAF1 T491I [cytosol] (R-HSA-9656019) p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol] (R-HSA-9656029) p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol] (R-HSA-9656031) p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol] (R-HSA-9656023) p-S338,Y341,S494,S621 RAF1 T491R [cytosol] (R-HSA-9656017) p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol] (R-HSA-9656062) p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol] (R-HSA-9656041) p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol] (R-HSA-9656058) p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol] (R-HSA-9656043) p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol] (R-HSA-9656053) p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol] (R-HSA-9656037) p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol] (R-HSA-9656050) p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol] (R-HSA-9656067) p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol] (R-HSA-9656077) p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol] (R-HSA-9656047) p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol] (R-HSA-9656056) p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol] (R-HSA-9656074) p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol] (R-HSA-9656080) p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol] (R-HSA-9656065) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.643	3
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.643	3
UniProt:Q9UMS6 SYNP2			0.611	6
UniProt:Q9BWU0 NADAP			0.602	8
UniProt:Q9NWT6 HIF1AN	1	HIF1AN [cytosol] (R-HSA-1234154)	0.59	2
UniProt:Q13085 ACACA	2	ACACA [cytosol] (R-HSA-1660609) Btn-ACACA [cytosol] (R-HSA-2976730)	0.564	2
UniProt:Q9NVI1 FANCI	3	p-4S-FANCI [nucleoplasm] (R-HSA-6788480) MonoUb-K523,p-4S-FANCI [nucleoplasm] (R-HSA-6785321) FANCI [nucleoplasm] (R-HSA-419529)	0.564	2
UniProt:P04792 HSPB1	3	p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) HSPB1 [cytosol] (R-HSA-450563) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.564	2
UniProt:P48059-3 LIMS1			0.556	3
UniProt:Q9NZ01 TECR	1	TECR [endoplasmic reticulum membrane] (R-HSA-548663)	0.527	2
UniProt:P78371 CCT2	3	CCT2 [extracellular region] (R-HSA-6806220) CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [cytosol] (R-HSA-390464)	0.527	2
UniProt:P61619 SEC61A1	2	SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813) SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591)	0.527	2
UniProt:O95831 AIFM1			0.527	2
UniProt:P16615 ATP2A2	2	ATP2A2 [endoplasmic reticulum membrane] (R-HSA-391962) ATP2A2 [platelet dense tubular network membrane] (R-HSA-427903)	0.527	2
UniProt:Q9BRK5 CAB45			0.527	2
UniProt:Q3ZCQ8 TIMM50	1	TIMM50 [mitochondrial inner membrane] (R-HSA-1252070)	0.527	2
UniProt:Q92616 GCN1	1	GCN1 [cytosol] (R-HSA-9633010)	0.527	2
UniProt:P49327 FASN	3	FASN [cytosol] (R-HSA-54659) decanoyl-FASN [cytosol] (R-HSA-5655935) FASN [cytosol] (R-HSA-199233)	0.527	2
UniProt:P78527 PRKDC	4	PRKDC [nucleoplasm] (R-HSA-62161) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [cytosol] (R-HSA-3134816) K48polyUb-PRKDC [cytosol] (R-HSA-8938766)	0.527	2
UniProt:Q9H0C8 ILKAP			0.508	3

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