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ILK [cytosol]
Stable Identifier
R-HSA-432864
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Integrin-linked protein kinase, ILK_HUMAN
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-extracellular matrix interactions (Homo sapiens)
Formation of the PINCH-ILK-parvin complex (Homo sapiens)
ILK [cytosol] (Homo sapiens)
PINCH-ILK-parvin complex [cytosol] (Homo sapiens)
ILK [cytosol] (Homo sapiens)
Localization of the PINCH-ILK-PARVIN complex to focal adhesions (Homo sapiens)
ILK interacts with beta-1 integrin (Homo sapiens)
ILK [cytosol] (Homo sapiens)
ILK:Integrin beta-1 [plasma membrane] (Homo sapiens)
ILK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13418 ILK
Gene Names
ILK, ILK1, ILK2
Chain
chain:1-452
Reference Genes
BioGPS Gene:3611 ILK
COSMIC (genes):ILK ILK
CTD Gene:3611 ILK
dbSNP Gene:3611 ILK
ENSEMBL:ENSG00000166333 ILK
HGNC:6040 ILK
KEGG Gene (Homo sapiens):3611 ILK
Monarch:3611 ILK
NCBI Gene:3611 ILK
OMIM:602366 ILK
UCSC:Q13418 ILK
Reference Transcript
RefSeq:NM_001014795.2 ILK
RefSeq:NM_001278442.1 ILK
RefSeq:XM_005252904.4 ILK
RefSeq:NM_001014794.2 ILK
RefSeq:NM_004517.3 ILK
RefSeq:NM_001278441.1 ILK
RefSeq:XM_011520065.1 ILK
RefSeq:XM_005252905.2 ILK
Other Identifiers
11724913_s_at
16721479
201234_at
3318891
3318892
3318893
3318894
3318895
3318896
3318901
3318903
3318904
3318906
3318908
3318910
3318911
3318912
3318913
3318914
3318915
3318916
35365_at
3611
7938154
A_14_P124609
A_23_P105066
A_24_P406870
GE59135
GE88667
GO:0000166
GO:0000902
GO:0001558
GO:0001658
GO:0001725
GO:0001934
GO:0001954
GO:0003151
GO:0003674
GO:0004672
GO:0004674
GO:0005178
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005925
GO:0006464
GO:0006468
GO:0006469
GO:0006950
GO:0007010
GO:0007049
GO:0007050
GO:0007155
GO:0007160
GO:0007165
GO:0007229
GO:0007267
GO:0007568
GO:0007569
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0009058
GO:0009967
GO:0010667
GO:0010761
GO:0014044
GO:0014912
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0017124
GO:0018105
GO:0019899
GO:0019901
GO:0019904
GO:0021675
GO:0022011
GO:0022607
GO:0030017
GO:0030027
GO:0030030
GO:0030054
GO:0030154
GO:0030335
GO:0030424
GO:0030513
GO:0032288
GO:0032956
GO:0032991
GO:0033209
GO:0034329
GO:0034330
GO:0034446
GO:0034641
GO:0040007
GO:0040011
GO:0042327
GO:0042995
GO:0043025
GO:0043034
GO:0043066
GO:0043167
GO:0043195
GO:0043198
GO:0043226
GO:0043406
GO:0043410
GO:0043491
GO:0043524
GO:0044877
GO:0045197
GO:0045663
GO:0045669
GO:0045773
GO:0045893
GO:0048646
GO:0048662
GO:0048812
GO:0048856
GO:0048870
GO:0050772
GO:0050775
GO:0051897
GO:0070527
GO:0090263
GO:0097435
GO:1901224
GO:2000178
ILMN_1693514
ILMN_1732827
ILMN_2358980
ILMN_2364376
TC11000133.hg
U40282_at
g4758605_3p_s_at
Participant Of
hasComponent
ILK:Integrin beta-1 [plasma membrane]
PINCH-ILK-parvin complex [cytosol]
input
Formation of the PINCH-ILK-parvin complex
ILK interacts with beta-1 integrin
Inferred To
Ilk [cytosol] (Drosophila melanogaster)
Ilk [cytosol] (Mus musculus)
Ilk [cytosol] (Rattus norvegicus)
pat-4 [cytosol] (Caenorhabditis elegans)
ilk [cytosol] (Danio rerio)
shkE [cytosol] (Dictyostelium discoideum)
shkC [cytosol] (Dictyostelium discoideum)
ILK [cytosol] (Canis familiaris)
ILK [cytosol] (Dictyostelium discoideum)
ILK [cytosol] (Plasmodium falciparum)
ILK [cytosol] (Sus scrofa)
ILK [cytosol] (Xenopus tropicalis)
drkD [cytosol] (Dictyostelium discoideum)
Homologues of ILK [cytosol] (Dictyostelium discoideum)
shkA [cytosol] (Dictyostelium discoideum)
shkD [cytosol] (Dictyostelium discoideum)
Cross References
RefSeq
XP_005252961.1
,
XP_005252962.1
,
XP_011518367.1
,
NP_004508.1
,
NP_001265370.1
,
NP_001265371.1
,
NP_001014794.1
,
NP_001014795.1
OpenTargets
ENSG00000166333
IntEnz
2.7.11.1
ZINC - Substances
ILK_HUMAN
HPA
ENSG00000166333-ILK
GeneCards
Q13418
ZINC target
Q13418
Ensembl
ENST00000396751
,
ENSG00000166333
,
ENSP00000434492
,
ENST00000528995
,
ENSP00000435323
,
ENSP00000403487
,
ENSP00000299421
,
ENST00000420936
,
ENST00000299421
,
ENSP00000379975
,
ENST00000532063
PRO
Q13418
ZINC - Predictions - Purchasable
ILK_HUMAN
HMDB Protein
HMDBP01460
PDB
2KBX
,
6MIB
,
3REP
,
3KMW
,
4HI8
,
3IXE
,
4HI9
,
3F6Q
,
3KMU
Interactors (36)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NVD7 PARVA
1
PARVA [cytosol]
(R-HSA-432848)
0.965
23
UniProt:P48059 LIMS1
1
LIMS1 [cytosol]
(R-HSA-432859)
0.952
14
UniProt:Q9HBI0 PARVG
0.831
12
UniProt:Q15404 RSU1
1
RSU1 [cytosol]
(R-HSA-446297)
0.802
5
UniProt:Q9HBI1 PARVB
1
PARVB [cytosol]
(R-HSA-446016)
0.744
4
UniProt:O60762 DPM1
4
DPM1 Q210Rfs*4 [endoplasmic reticulum membrane]
(R-HSA-4717361)
DPM1 R92G [endoplasmic reticulum membrane]
(R-HSA-4717370)
DPM1 G111Lfs*45 [endoplasmic reticulum membrane]
(R-HSA-4717383)
DPM1 [endoplasmic reticulum membrane]
(R-HSA-162865)
0.669
3
UniProt:P49023 PXN
4
PXN [plasma membrane]
(R-HSA-180493)
p-Y-PXN [plasma membrane]
(R-HSA-9031680)
PXN [cytosol]
(R-HSA-210014)
p-Y31,Y118-PXN [cytosol]
(R-HSA-5218693)
0.669
4
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.666
4
UniProt:Q6R327 RICTOR
1
RICTOR [cytosol]
(R-HSA-198632)
0.659
8
UniProt:Q99832 CCT7
1
CCT7 [cytosol]
(R-HSA-390451)
0.643
3
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.643
3
UniProt:P50990 CCT8
5
CCT8 [extracellular region]
(R-HSA-6806238)
CCT8 [secretory granule lumen]
(R-HSA-6801035)
CCT8 [ficolin-1-rich granule lumen]
(R-HSA-6800894)
CCT8 [azurophil granule lumen]
(R-HSA-6799369)
CCT8 [cytosol]
(R-HSA-390449)
0.643
3
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.643
3
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.643
3
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.643
3
UniProt:P27708 CAD
1
CAD [cytosol]
(R-HSA-73452)
0.643
3
UniProt:P04049 RAF1
54
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
RAF1 [cytosol]
(R-HSA-167205)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
p-S621-RAF1 G361A [cytosol]
(R-HSA-9656092)
p-S621-RAF1 G370R [cytosol]
(R-HSA-9656094)
p-S621-RAF1 D486G [cytosol]
(R-HSA-9656085)
p-S621-RAF1 T491R [cytosol]
(R-HSA-9656145)
p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol]
(R-HSA-9656026)
p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol]
(R-HSA-9656070)
p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol]
(R-HSA-9656035)
p-S338,Y341,S494,S621-RAF1 T491I [cytosol]
(R-HSA-9656019)
p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol]
(R-HSA-9656029)
p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol]
(R-HSA-9656031)
p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol]
(R-HSA-9656023)
p-S338,Y341,S494,S621 RAF1 T491R [cytosol]
(R-HSA-9656017)
p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol]
(R-HSA-9656062)
p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol]
(R-HSA-9656041)
p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol]
(R-HSA-9656058)
p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol]
(R-HSA-9656043)
p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol]
(R-HSA-9656053)
p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol]
(R-HSA-9656037)
p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol]
(R-HSA-9656050)
p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol]
(R-HSA-9656067)
p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol]
(R-HSA-9656077)
p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol]
(R-HSA-9656047)
p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol]
(R-HSA-9656056)
p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol]
(R-HSA-9656074)
p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol]
(R-HSA-9656080)
p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol]
(R-HSA-9656065)
hyperphosphorylated RAF1 [plasma membrane]
(R-HSA-5675193)
p-S621-RAF1 [plasma membrane]
(R-HSA-206222)
p-Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5675420)
p-S259,S621-RAF1 [cytosol]
(R-HSA-109786)
p-S621-RAF1 [cytosol]
(R-HSA-206028)
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5672665)
p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
(R-HSA-5672664)
0.643
3
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.643
3
UniProt:Q9UMS6 SYNP2
0.611
6
UniProt:Q9BWU0 NADAP
0.602
8
UniProt:Q9NWT6 HIF1AN
1
HIF1AN [cytosol]
(R-HSA-1234154)
0.59
2
UniProt:Q13085 ACACA
2
ACACA [cytosol]
(R-HSA-1660609)
Btn-ACACA [cytosol]
(R-HSA-2976730)
0.564
2
UniProt:Q9NVI1 FANCI
3
p-4S-FANCI [nucleoplasm]
(R-HSA-6788480)
MonoUb-K523,p-4S-FANCI [nucleoplasm]
(R-HSA-6785321)
FANCI [nucleoplasm]
(R-HSA-419529)
0.564
2
UniProt:P04792 HSPB1
3
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
HSPB1 [cytosol]
(R-HSA-450563)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.564
2
UniProt:P48059-3 LIMS1
0.556
3
UniProt:Q9NZ01 TECR
1
TECR [endoplasmic reticulum membrane]
(R-HSA-548663)
0.527
2
UniProt:P78371 CCT2
3
CCT2 [extracellular region]
(R-HSA-6806220)
CCT2 [azurophil granule lumen]
(R-HSA-6799356)
CCT2 [cytosol]
(R-HSA-390464)
0.527
2
UniProt:P61619 SEC61A1
2
SEC61A1 [phagocytic vesicle membrane]
(R-HSA-1236813)
SEC61A1 [endoplasmic reticulum membrane]
(R-HSA-444591)
0.527
2
UniProt:O95831 AIFM1
0.527
2
UniProt:P16615 ATP2A2
2
ATP2A2 [endoplasmic reticulum membrane]
(R-HSA-391962)
ATP2A2 [platelet dense tubular network membrane]
(R-HSA-427903)
0.527
2
UniProt:Q9BRK5 CAB45
0.527
2
UniProt:Q3ZCQ8 TIMM50
1
TIMM50 [mitochondrial inner membrane]
(R-HSA-1252070)
0.527
2
UniProt:Q92616 GCN1
1
GCN1 [cytosol]
(R-HSA-9633010)
0.527
2
UniProt:P49327 FASN
3
FASN [cytosol]
(R-HSA-54659)
decanoyl-FASN [cytosol]
(R-HSA-5655935)
FASN [cytosol]
(R-HSA-199233)
0.527
2
UniProt:P78527 PRKDC
4
PRKDC [nucleoplasm]
(R-HSA-62161)
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
PRKDC [cytosol]
(R-HSA-3134816)
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
0.527
2
UniProt:Q9H0C8 ILKAP
0.508
3
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