Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
ILK [cytosol]
Stable Identifier
R-HSA-432864
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Integrin-linked protein kinase, ILK_HUMAN
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-extracellular matrix interactions (Homo sapiens)
Formation of the PINCH-ILK-parvin complex (Homo sapiens)
ILK [cytosol] (Homo sapiens)
PINCH-ILK-parvin complex [cytosol] (Homo sapiens)
ILK [cytosol] (Homo sapiens)
Localization of the PINCH-ILK-PARVIN complex to focal adhesions (Homo sapiens)
ILK interacts with beta-1 integrin (Homo sapiens)
ILK [cytosol] (Homo sapiens)
ILK:Integrin beta-1 [plasma membrane] (Homo sapiens)
ILK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13418 ILK
Gene Names
ILK, ILK1, ILK2
Chain
chain:1-452
Reference Genes
BioGPS Gene:3611 ILK
COSMIC (genes):ILK ILK
CTD Gene:3611 ILK
dbSNP Gene:3611 ILK
ENSEMBL:ENSG00000166333 ILK
HGNC:6040 ILK
KEGG Gene (Homo sapiens):3611 ILK
Monarch:3611 ILK
NCBI Gene:3611 ILK
OMIM:602366 ILK
UCSC:Q13418 ILK
Reference Transcript
RefSeq:NM_004517.3 ILK
RefSeq:XM_005252904.4 ILK
RefSeq:NM_001014795.2 ILK
RefSeq:NM_001014794.2 ILK
RefSeq:XM_011520065.1 ILK
RefSeq:XM_005252905.2 ILK
RefSeq:NM_001278442.1 ILK
RefSeq:NM_001278441.1 ILK
Other Identifiers
11724913_s_at
16721479
201234_PM_at
201234_at
3318891
3318892
3318893
3318894
3318895
3318896
3318901
3318903
3318904
3318906
3318908
3318910
3318911
3318912
3318913
3318914
3318915
3318916
35365_at
3611
7938154
A_14_P124609
A_23_P105066
A_24_P406870
GE59135
GE88667
GO:0000166
GO:0000902
GO:0001658
GO:0001725
GO:0001934
GO:0003151
GO:0003674
GO:0004672
GO:0004674
GO:0004712
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0006464
GO:0006468
GO:0006950
GO:0007155
GO:0007160
GO:0007165
GO:0007229
GO:0007267
GO:0008150
GO:0008283
GO:0008284
GO:0009058
GO:0009967
GO:0010761
GO:0014044
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0019899
GO:0019901
GO:0021675
GO:0022011
GO:0030017
GO:0030027
GO:0030030
GO:0030054
GO:0030154
GO:0030513
GO:0033209
GO:0034446
GO:0034641
GO:0040011
GO:0042327
GO:0042995
GO:0043167
GO:0043226
GO:0043491
GO:0045197
GO:0045669
GO:0045893
GO:0048856
GO:0048870
GO:0070527
GO:0090263
GO:0106310
GO:1900026
GO:1901224
GO:2000178
HMNXSV003056947
ILMN_1693514
ILMN_1732827
ILMN_2358980
ILMN_2364376
TC11000133.hg
U40282_at
g4758605_3p_s_at
Participates
as a component of
ILK:Integrin beta-1 [plasma membrane] (Homo sapiens)
PINCH-ILK-parvin complex [cytosol] (Homo sapiens)
as an input of
ILK interacts with beta-1 integrin (Homo sapiens)
Formation of the PINCH-ILK-parvin complex (Homo sapiens)
Inferred To
Ilk [cytosol]
(Drosophila melanogaster)
Ilk [cytosol]
(Mus musculus)
Ilk [cytosol]
(Rattus norvegicus)
pat-4 [cytosol]
(Caenorhabditis elegans)
ilk [cytosol]
(Danio rerio)
ilk [cytosol]
(Xenopus tropicalis)
ILK [cytosol]
(Bos taurus)
ILK [cytosol]
(Canis familiaris)
ILK [cytosol]
(Dictyostelium discoideum)
ILK [cytosol]
(Plasmodium falciparum)
ILK [cytosol]
(Sus scrofa)
Homologues of ILK [cytosol]
(Plasmodium falciparum)
pTKL [cytosol]
(Plasmodium falciparum)
Cross References
RefSeq
NP_001265370.1
,
NP_001014795.1
,
XP_011518367.1
,
NP_004508.1
,
NP_001265371.1
,
XP_005252962.1
,
NP_001014794.1
,
XP_005252961.1
Guide to Pharmacology - Targets
2041
OpenTargets
ENSG00000166333
ZINC - Substances
ILK_HUMAN
ZINC target
Q13418
PRO
Q13418
PDB
3IXE
,
3KMW
,
3REP
,
2KBX
,
3F6Q
,
4HI8
,
4HI9
,
3KMU
,
6MIB
ZINC - Investigational
ILK_HUMAN
ZINC - Metabolites
ILK_HUMAN
HPA
ENSG00000166333-ILK
GeneCards
Q13418
Ensembl
ENST00000396751
,
ENST00000528995
,
ENSP00000299421
,
ENSP00000403487
,
ENST00000420936
,
ENSP00000435323
,
ENST00000532063
,
ENST00000299421
,
ENSP00000379975
,
ENSG00000166333
,
ENSP00000434492
Pharos - Targets
Q13418
ZINC - Predictions - Purchasable
ILK_HUMAN
HMDB Protein
HMDBP01460
Interactors (53)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NVD7 PARVA
1
PARVA [cytosol]
(R-HSA-432848)
0.967
24
UniProt:P48059 LIMS1
1
LIMS1 [cytosol]
(R-HSA-432859)
0.955
15
UniProt:Q15404 RSU1
1
RSU1 [cytosol]
(R-HSA-446297)
0.848
6
UniProt:Q9HBI0 PARVG
0.831
12
UniProt:Q9HBI1 PARVB
1
PARVB [cytosol]
(R-HSA-446016)
0.802
5
UniProt:Q99832 CCT7
1
CCT7 [cytosol]
(R-HSA-390451)
0.725
4
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.725
4
UniProt:P50990 CCT8
5
CCT8 [ficolin-1-rich granule lumen]
(R-HSA-6800894)
CCT8 [extracellular region]
(R-HSA-6806238)
CCT8 [secretory granule lumen]
(R-HSA-6801035)
CCT8 [azurophil granule lumen]
(R-HSA-6799369)
CCT8 [cytosol]
(R-HSA-390449)
0.725
4
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.725
4
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.725
4
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.725
4
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.725
4
UniProt:P27708 CAD
1
CAD [cytosol]
(R-HSA-73452)
0.725
4
UniProt:Q9NVI1 FANCI
3
MonoUb-K523,p-4S-FANCI [nucleoplasm]
(R-HSA-6785321)
FANCI [nucleoplasm]
(R-HSA-419529)
p-4S-FANCI [nucleoplasm]
(R-HSA-6788480)
0.669
3
UniProt:O60762 DPM1
4
DPM1 R92G [endoplasmic reticulum membrane]
(R-HSA-4717370)
DPM1 Q210Rfs*4 [endoplasmic reticulum membrane]
(R-HSA-4717361)
DPM1 G111Lfs*45 [endoplasmic reticulum membrane]
(R-HSA-4717383)
DPM1 [endoplasmic reticulum membrane]
(R-HSA-162865)
0.669
3
UniProt:P49023 PXN
4
p-Y-PXN [plasma membrane]
(R-HSA-9031680)
PXN [plasma membrane]
(R-HSA-180493)
PXN [cytosol]
(R-HSA-210014)
p-Y31,Y118-PXN [cytosol]
(R-HSA-5218693)
0.669
4
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.666
4
UniProt:Q6R327 RICTOR
1
RICTOR [cytosol]
(R-HSA-198632)
0.659
8
UniProt:P78371 CCT2
3
CCT2 [azurophil granule lumen]
(R-HSA-6799356)
CCT2 [extracellular region]
(R-HSA-6806220)
CCT2 [cytosol]
(R-HSA-390464)
0.643
3
UniProt:Q92616 GCN1
1
GCN1 [cytosol]
(R-HSA-9633010)
0.643
3
UniProt:P16615 ATP2A2
2
ATP2A2 [endoplasmic reticulum membrane]
(R-HSA-391962)
ATP2A2 [platelet dense tubular network membrane]
(R-HSA-427903)
0.643
3
UniProt:Q9BRK5 CAB45
0.643
3
UniProt:P78527 PRKDC
4
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
PRKDC [cytosol]
(R-HSA-3134816)
PRKDC [nucleoplasm]
(R-HSA-62161)
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
0.643
3
UniProt:P04049 RAF1
20
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
p-S621-RAF1 G361A [cytosol]
(R-HSA-9656092)
p-S621-RAF1 G370R [cytosol]
(R-HSA-9656094)
0.643
3
UniProt:Q9UMS6 SYNP2
0.611
6
UniProt:Q9BWU0 NADAP
0.602
8
UniProt:Q9NWT6 HIF1AN
1
HIF1AN [cytosol]
(R-HSA-1234154)
0.59
2
UniProt:Q16531 DDB1
1
DDB1 [nucleoplasm]
(R-HSA-53489)
0.564
2
UniProt:P04792 HSPB1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.564
2
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
2
UniProt:Q13085 ACACA
2
Btn-ACACA [cytosol]
(R-HSA-2976730)
ACACA [cytosol]
(R-HSA-1660609)
0.564
2
UniProt:P48059-3 LIMS1
0.556
3
UniProt:Q9NZ01 TECR
1
TECR [endoplasmic reticulum membrane]
(R-HSA-548663)
0.527
2
UniProt:P36776 LONM
0.527
2
UniProt:Q9ULX6 AKP8L
0.527
2
UniProt:P61619 SEC61A1
2
SEC61A1 [endoplasmic reticulum membrane]
(R-HSA-444591)
SEC61A1 [phagocytic vesicle membrane]
(R-HSA-1236813)
0.527
2
UniProt:O00165 HAX1
0.527
2
UniProt:Q8NE01 CNNM3
0.527
2
UniProt:A1L0T0 HACL2
0.527
2
UniProt:P04439 HLA-A
9
K48polyUb-HLA-A A-3 [endoplasmic reticulum membrane]
(R-HSA-8943086)
HLA-A A-3 [endoplasmic reticulum membrane]
(R-HSA-8943090)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [ER to Golgi transport vesicle membrane]
(R-HSA-983347)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [Golgi membrane]
(R-HSA-983376)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [phagocytic vesicle membrane]
(R-HSA-1236740)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [recycling endosome membrane]
(R-HSA-8863889)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [plasma membrane]
(R-HSA-197642)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [early endosome membrane]
(R-HSA-1236826)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-983100)
0.527
2
UniProt:Q96EY1 DNJA3
0.527
2
UniProt:P05023 ATP1A1
1
ATP1A1 [plasma membrane]
(R-HSA-936850)
0.527
2
UniProt:O95831 AIFM1
0.527
2
UniProt:P00367 GLUD1
3
Ack-GLUD1 [mitochondrial matrix]
(R-HSA-5688293)
RibC-GLUD1 [mitochondrial matrix]
(R-HSA-5688244)
GLUD1 [mitochondrial matrix]
(R-HSA-70582)
0.527
2
UniProt:Q7Z4I7 LIMS2
1
LIMS2 [cytosol]
(R-HSA-446078)
0.527
2
UniProt:Q14257 RCN2
0.527
2
UniProt:Q3ZCQ8 TIMM50
1
TIMM50 [mitochondrial inner membrane]
(R-HSA-1252070)
0.527
2
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.527
2
UniProt:P49327 FASN
3
decanoyl-FASN [cytosol]
(R-HSA-5655935)
FASN [cytosol]
(R-HSA-54659)
FASN [cytosol]
(R-HSA-199233)
0.527
2
UniProt:P27361 MAPK3
6
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [nucleoplasm]
(R-HSA-73724)
MAPK3 [cytosol]
(R-HSA-59284)
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
0.527
3
UniProt:Q8NF37 LPCAT1
3
LPCAT1 [plasma membrane]
(R-HSA-6806273)
LPCAT1 [azurophil granule membrane]
(R-HSA-6798758)
LPCAT1 [endoplasmic reticulum membrane]
(R-HSA-1498772)
0.527
2
UniProt:Q13451 FKBP5
2
FKBP5 [cytosol]
(R-HSA-5618096)
FKBP5 [nucleoplasm]
(R-HSA-8939165)
0.527
2
UniProt:Q9H0C8 ILKAP
0.508
3
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
