Reactome | ILK [cytosol]

ILK [cytosol]

Stable Identifier

R-HSA-432864

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Integrin-linked protein kinase, ILK_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q16531 DDB1

Expand all

External Reference Information

External Reference

UniProt:Q13418 ILK

Gene Names

ILK, ILK1, ILK2

Chain

chain:1-452

Reference Genes

BioGPS Gene:3611 ILK

COSMIC (genes):ILK ILK

CTD Gene:3611 ILK

dbSNP Gene:3611 ILK

ENSEMBL:ENSG00000166333 ILK

ENSEMBL_homo_sapiens_GENE:ENSG00000166333.14 ILK

HGNC:6040 ILK

KEGG Gene (Homo sapiens):3611 ILK

Monarch:3611 ILK

NCBI Gene:3611 ILK

OMIM:602366 ILK

UCSC:Q13418 ILK

Reference Transcript

Other Identifiers

11724913_s_at

16721479

201234_PM_at

201234_at

3318891

3318892

3318893

3318894

3318895

3318896

3318901

3318903

3318904

3318906

3318908

3318910

3318911

3318912

3318913

3318914

3318915

3318916

35365_at

3611

7938154

A_14_P124609

A_23_P105066

A_24_P406870

GE59135

GE88667

GO:0000166

GO:0000902

GO:0001658

GO:0001725

GO:0001934

GO:0003151

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0006351

GO:0006355

GO:0006468

GO:0007155

GO:0007160

GO:0007163

GO:0007229

GO:0008283

GO:0008284

GO:0009967

GO:0010761

GO:0014044

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0019901

GO:0021675

GO:0022011

GO:0023052

GO:0030017

GO:0030027

GO:0030030

GO:0030154

GO:0030513

GO:0033209

GO:0034446

GO:0036211

GO:0042060

GO:0042327

GO:0042995

GO:0043123

GO:0043226

GO:0043491

GO:0045197

GO:0045669

GO:0045893

GO:0048856

GO:0048870

GO:0061351

GO:0070161

GO:0070527

GO:0090263

GO:0106310

GO:0140096

GO:1900026

GO:2000178

HMNXSV003056947

ILMN_1732827

ILMN_2358980

ILMN_2364376

TC11000133.hg

U40282_at

g4758605_3p_s_at

Participates

as a component of

as an input of

Inferred To

Ilk [cytosol] (Drosophila melanogaster)

pat-4 [cytosol] (Caenorhabditis elegans)

ilk [cytosol] (Danio rerio)

ilk [cytosol] (Xenopus tropicalis)

ILK [cytosol] (Bos taurus)

ILK [cytosol] (Canis familiaris)

ILK [cytosol] (Dictyostelium discoideum)

ILK [cytosol] (Mus musculus)

ILK [cytosol] (Rattus norvegicus)

ILK [cytosol] (Sus scrofa)

Homologues of ILK [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

XP_005252962.1, XP_011518367.1, NP_001014794.1, NP_004508.1, NP_001265371.1, NP_001265370.1, XP_005252961.1, NP_001014795.1

Guide to Pharmacology - Targets

2041

OpenTargets

ENSG00000166333

ZINC - Substances

ILK_HUMAN

ZINC target

Q13418

PRO

Q13418

PDB

2KBX, 3KMW, 4HI9, 3IXE, 3F6Q, 3KMU, 6MIB, 3REP, 4HI8

IntEnz

2.7.11.1

HPA

ENSG00000166333-ILK

GeneCards

Q13418

Ensembl

ENSP00000435323, ENST00000299421, ENST00000532063, ENSP00000299421, ENST00000420936, ENST00000528995, ENST00000396751, ENSP00000403487, ENSG00000166333, ENSP00000434492, ENSP00000379975

Pharos - Targets

Q13418

ZINC - Predictions - Purchasable

ILK_HUMAN

HMDB Protein

HMDBP01460

Interactors (56)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NVD7 PARVA	1	PARVA [cytosol] (R-HSA-432848)	0.97	27
UniProt:P48059 LIMS1	1	LIMS1 [cytosol] (R-HSA-432859)	0.961	18
UniProt:Q15404 RSU1	1	RSU1 [cytosol] (R-HSA-446297)	0.899	9
UniProt:Q9HBI1 PARVB	1	PARVB [cytosol] (R-HSA-446016)	0.886	8
UniProt:Q9HBI0 PARVG			0.871	14
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.725	4
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.725	4
UniProt:P50990 CCT8	5	CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [cytosol] (R-HSA-390449)	0.725	4
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.725	4
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.725	4
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.725	4
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.725	4
UniProt:P27708 CAD	1	CAD [cytosol] (R-HSA-73452)	0.725	4
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.669	4
UniProt:O60762 DPM1	4	DPM1 R92G [endoplasmic reticulum membrane] (R-HSA-4717370) DPM1 Q210Rfs4 [endoplasmic reticulum membrane] (R-HSA-4717361) DPM1 G111Lfs45 [endoplasmic reticulum membrane] (R-HSA-4717383) DPM1 [endoplasmic reticulum membrane] (R-HSA-162865)	0.669	3
UniProt:Q9NVI1 FANCI	3	MonoUb-K523,p-4S-FANCI [nucleoplasm] (R-HSA-6785321) p-4S-FANCI [nucleoplasm] (R-HSA-6788480) FANCI [nucleoplasm] (R-HSA-419529)	0.669	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.666	4
UniProt:Q6R327 RICTOR	1	RICTOR [cytosol] (R-HSA-198632)	0.659	8
UniProt:P78371 CCT2	3	CCT2 [extracellular region] (R-HSA-6806220) CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [cytosol] (R-HSA-390464)	0.643	3
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [nucleoplasm] (R-HSA-62161)	0.643	3
UniProt:Q92616 GCN1	1	GCN1 [cytosol] (R-HSA-9633010)	0.643	3
UniProt:P16615 ATP2A2	2	ATP2A2 [platelet dense tubular network membrane] (R-HSA-427903) ATP2A2 [endoplasmic reticulum membrane] (R-HSA-391962)	0.643	3
UniProt:Q9BRK5 CAB45			0.643	3
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.643	3
UniProt:Q9UMS6 SYNP2			0.611	6
UniProt:Q9BWU0 NADAP			0.602	7
UniProt:Q9NWT6 HIF1AN	1	HIF1AN [cytosol] (R-HSA-1234154)	0.59	2
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.564	2
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.564	2
UniProt:Q13085 ACACA	2	ACACA [cytosol] (R-HSA-1660609) Btn-ACACA [cytosol] (R-HSA-2976730)	0.564	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	2
UniProt:P48059-3 LIMS1			0.556	3
UniProt:Q9NZ01 TECR	1	TECR [endoplasmic reticulum membrane] (R-HSA-548663)	0.527	2
UniProt:P36776 LONP1	1	LONP1 [mitochondrial matrix] (R-HSA-9838000)	0.527	2
UniProt:P49327 FASN	3	FASN [cytosol] (R-HSA-199233) decanoyl-FASN [cytosol] (R-HSA-5655935) FASN [cytosol] (R-HSA-54659)	0.527	2
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.527	2
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.527	2
UniProt:P61619 SEC61A1	2	SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591) SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813)	0.527	2
UniProt:O00165 HAX1			0.527	2
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	2
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.527	2
UniProt:P27361 MAPK3	6	MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [nucleoplasm] (R-HSA-73724) MAPK3 [cytosol] (R-HSA-59284) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359)	0.527	3
UniProt:A1L0T0 HACL2			0.527	2
UniProt:Q8NE01 CNNM3			0.527	2
UniProt:P04439 HLA-A	9	K48polyUb-HLA-A A-2 [endoplasmic reticulum membrane] (R-HSA-8943073) HLA-A A-3 [endoplasmic reticulum membrane] (R-HSA-8943090) HLA class I histocompatibility antigen, A-3 alpha chain precursor [phagocytic vesicle membrane] (R-HSA-1236740) HLA class I histocompatibility antigen, A-3 alpha chain precursor [recycling endosome membrane] (R-HSA-8863889) HLA class I histocompatibility antigen, A-3 alpha chain precursor [early endosome membrane] (R-HSA-1236826) HLA class I histocompatibility antigen, A-3 alpha chain precursor [plasma membrane] (R-HSA-197642) HLA class I histocompatibility antigen, A-3 alpha chain precursor [Golgi membrane] (R-HSA-983376) HLA class I histocompatibility antigen, A-3 alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-983347) HLA class I histocompatibility antigen, A-3 alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983100)	0.527	2
UniProt:P54652 HSPA2	2	HSPA2 [cytosol] (R-HSA-3371408) HSPA2 [nucleoplasm] (R-HSA-912480)	0.527	2
UniProt:Q96EY1 DNJA3			0.527	2
UniProt:P05023 ATP1A1	1	ATP1A1 [plasma membrane] (R-HSA-936850)	0.527	2
UniProt:O95831 AIFM1			0.527	2
UniProt:Q8NF37 LPCAT1	3	LPCAT1 [plasma membrane] (R-HSA-6806273) LPCAT1 [azurophil granule membrane] (R-HSA-6798758) LPCAT1 [endoplasmic reticulum membrane] (R-HSA-1498772)	0.527	2
UniProt:Q7Z4I7 LIMS2	1	LIMS2 [cytosol] (R-HSA-446078)	0.527	2
UniProt:P00367 GLUD1	3	Ack-GLUD1 [mitochondrial matrix] (R-HSA-5688293) RibC-GLUD1 [mitochondrial matrix] (R-HSA-5688244) GLUD1 [mitochondrial matrix] (R-HSA-70582)	0.527	2
UniProt:Q14257 RCN2			0.527	2
UniProt:Q3ZCQ8 TIMM50	1	TIMM50 [mitochondrial inner membrane] (R-HSA-1252070)	0.527	2
UniProt:Q9H0C8 ILKAP			0.508	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	2

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