Reactome | PTPN12 [cytosol]

PTPN12 [cytosol]

Stable Identifier

R-HSA-432933

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PTP-PEST, Tyrosine-protein phosphatase non-receptor type 12, PTN12_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9P0L0 VAPA

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External Reference Information

External Reference

UniProt:Q05209 PTPN12

Gene Names

PTPN12

Chain

chain:1-780

Reference Genes

BioGPS Gene:5782 PTPN12

COSMIC (genes):PTPN12 PTPN12

CTD Gene:5782 PTPN12

dbSNP Gene:5782 PTPN12

ENSEMBL:ENSG00000127947 PTPN12

ENSEMBL_homo_sapiens_GENE:ENSG00000127947.16 PTPN12

HGNC:9645 PTPN12

KEGG Gene (Homo sapiens):5782 PTPN12

Monarch:5782 PTPN12

NCBI Gene:5782 PTPN12

OMIM:600079 PTPN12

UCSC:Q05209 PTPN12

Reference Transcript

Other Identifiers

11717887_s_at

11732037_a_at

11740181_a_at

1463_at

17047652

202006_PM_at

202006_at

216915_PM_s_at

216915_s_at

3009960

3009961

3009962

3009963

3009964

3009976

3009977

3009979

3009981

3009982

3009983

3009985

3009993

3009995

3009996

3009997

3009999

3010004

3010007

3010010

3010012

3010014

3010015

3010016

5782

8133788

A_14_P126061

A_23_P8763

GE58151

GO:0002102

GO:0003824

GO:0004721

GO:0004725

GO:0004726

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005925

GO:0006470

GO:0016311

GO:0016787

GO:0016791

GO:0017124

GO:0023052

GO:0035335

GO:0036211

GO:0042058

GO:0042246

GO:0042995

GO:0043226

GO:0043229

GO:0048856

GO:0070161

GO:0071364

GO:0140096

GO:1901185

GO:2000587

HMNXSV003039324

Hs.62.1.S1_3p_a_at

ILMN_1695509

ILMN_2222074

M93425_at

PH_hs_0000009

TC07000495.hg

TC07002426.hg

g4506286_3p_at

Participates

as a component of

p-S139,3Y-SHC1-1,p-S29,3Y-SHC1-2:PTPN12 [cytosol] (Homo sapiens)

as an input of

SHC1 binds PTPN12 (Homo sapiens)

This entity regulates

Negatively

Other forms of this molecule

PTPN12 [nucleoplasm]

Inferred To

Ptpn12 [cytosol] (Rattus norvegicus)

ptpn12 [cytosol] (Danio rerio)

ptpn12 [cytosol] (Xenopus tropicalis)

PTPN12 [cytosol] (Bos taurus)

PTPN12 [cytosol] (Canis familiaris)

PTPN12 [cytosol] (Gallus gallus)

PTPN12 [cytosol] (Mus musculus)

PTPN12 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001124480.1, NP_001124481.1, NP_002826.3

OpenTargets

ENSG00000127947

HPA

ENSG00000127947-PTPN12

GeneCards

Q05209

ZINC - Substances

PTN12_HUMAN

ZINC target

Q05209

Ensembl

ENSG00000127947, ENST00000415482, ENST00000435495, ENST00000248594, ENSP00000248594, ENSP00000392429, ENSP00000397991

PRO

Q05209

Pharos - Targets

Q05209

ZINC - Predictions - Purchasable

PTN12_HUMAN

PDB

5HDE, 5J8R, 5O2P

HMDB Protein

HMDBP08927

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) SHC1 [cytosol] (R-HSA-74680) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.856	9
UniProt:O43586 PSTPIP1	1	PSTPIP1 [cytosol] (R-HSA-879220)	0.835	9
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.807	5
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.762	4
UniProt:Q9H939 PPIP2			0.745	6
UniProt:P09619 PDGFRB	3	p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039) PDGFRB [plasma membrane] (R-HSA-186767) p-12Y-PDGFRB [plasma membrane] (R-HSA-186803)	0.704	3
UniProt:P56945 BCAR1	4	p-Y-BCAR1 [cytosol] (R-HSA-372645) p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) BCAR1 [cytosol] (R-HSA-201625)	0.691	5
UniProt:P42768 WAS	2	WAS [cytosol] (R-HSA-201879) p-Y291-WAS [cytosol] (R-HSA-2197668)	0.609	2
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.592	4
UniProt:P29350 PTPN6	5	PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.564	3
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [cytosol] (R-HSA-9609920)	0.527	3
UniProt:O60711 LPXN			0.527	3

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