Reactome | CBL binds TGFBR2

CBL binds TGFBR2

Stable Identifier

R-HSA-4332235

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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The E3 ubiquitin ligase CBL binds the cytoplasmic tail of plasma membrane-bound TGFBR2 (TGF-beta receptor 2) but not TGFBR1 (TGF-beta receptor 1). The tyrosine kinase binding (TKB) domain of CBL is involved in this interaction (Zuo et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23290524	c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-? type II receptor Chen, Y, Deng, H, Zuo, W, Zhang, T, Luo, S, Ding, Y, Gao, C, Feng, XH, Huang, F, Chen, YG, Du, J, Chiang, YJ, Jeong, LS, Lee, HW, Li, M	Mol. Cell	2013