CAMK2 binds MAP3K7

Stable Identifier
R-HSA-4332356
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Several studies in C. elegans and vertebrates suggest that a TAK1-NLK kinase cascade regulates the activity of the canonical WNT signaling pathway (Ishitani et al, 1999; Meneghini et al, 1999; Shin et al, 1999; Rocheleau et al, 1999). Activation of this MAPK cascade depends on CAMK2 activity downstream of WNT5a non-canonical signaling (Ishitani et al, 2003a, b). CAMK2 co-precipitates with TAK1/MAP3K7 upon co-transfection in HEK293 cells and calcium signaling activates MAP3K7 in a CAMK2-dependent manner (Ishitani et al, 2003a).

Literature References
PubMed ID Title Journal Year
10488343 MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans

Shin, TH, Yasuda, J, Rocheleau, CE, Lin, R, Soto, M, Bei, Y, Davis, RJ, Mello, CC

Mol. Cell 1999
10391246 MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans

Meneghini, MD, Ishitani, T, Carter, JC, Hisamoto, N, Ninomiya-Tsuji, J, Thorpe, CJ, Hamill, DR, Matsumoto, K, Bowerman, B

Nature 1999
12556497 Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling

Ishitani, T, Ninomiya-Tsuji, J, Matsumoto, K

Mol. Cell. Biol. 2003
10380924 WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans

Rocheleau, CE, Yasuda, J, Shin, TH, Lin, R, Sawa, H, Okano, H, Priess, JR, Davis, RJ, Mello, CC

Cell 1999
12482967 The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling

Ishitani, T, Kishida, S, Hyodo-Miura, J, Ueno, N, Yasuda, J, Waterman, M, Shibuya, H, Moon, RT, Ninomiya-Tsuji, J, Matsumoto, K

Mol. Cell. Biol. 2003
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