SUMOylation of NR3C1 (GR) with SUMO1

Stable Identifier
R-HSA-4341025
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SUMOylation of Glucocorticoid receptor with SUMO1
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SUMOylation of NR3C1 (GR) with SUMO1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NR3C1 (Glucocorticoid receptor, GR) is SUMOylated at lysine-277 and lysine-293 with SUMO1 (Tian et al. 2002, Impens et al. 2014). SUMOylation is enhanced when NR3C1 binds ligand (dexamethasone). SUMOylation reduces transcription activation by NR3C1.

Literature References
PubMed ID Title Journal Year
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Radoshevich, L, Cossart, P, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
12144530 Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor

Tian, S, Poukka, H, Palvimo, JJ, Jänne, OA

Biochem. J. 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
SUMO1:C93-UBE2I [nucleoplasm]
Activity
SUMO transferase activity (0019789)
Orthologous Events
SUMOylation of NR3C1 (GR) with SUMO1 (Bos taurus)
SUMOylation of NR3C1 (GR) with SUMO1 (Canis familiaris)
SUMOylation of NR3C1 (GR) with SUMO1 (Danio rerio)
SUMOylation of NR3C1 (GR) with SUMO1 (Gallus gallus)
SUMOylation of NR3C1 (GR) with SUMO1 (Mus musculus)
SUMOylation of NR3C1 (GR) with SUMO1 (Rattus norvegicus)
SUMOylation of NR3C1 (GR) with SUMO1 (Xenopus tropicalis)
Authored
May, B  (2013-08-14)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-08-19)