SUMOylation of NR3C1 (GR) with SUMO1

Stable Identifier
R-HSA-4341025
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
SUMOylation of Glucocorticoid receptor with SUMO1
Locations in the PathwayBrowser
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NR3C1 (Glucocorticoid receptor, GR) is SUMOylated at lysine-277 and lysine-293 with SUMO1 (Tian et al. 2002, Impens et al. 2014). SUMOylation is enhanced when NR3C1 binds ligand (dexamethasone). SUMOylation reduces transcription activation by NR3C1.

Literature References
PubMed ID Title Journal Year
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Radoshevich, L, Cossart, P, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
12144530 Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor

Tian, S, Poukka, H, Palvimo, JJ, Jänne, OA

Biochem. J. 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created